Search results for "changes"
showing 10 items of 901 documents
Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological …
1991
Cyclic adenosine monophosphate (cAMP) is an adenylate cyclase borne second messenger involved in basic metabolic events. The beta-adrenoceptor sensitive adenylate cyclase was studied in post-mortem hippocampi of controls and Alzheimer patients. Virtually identical subsets of each hippocampus homogenate were stimulated by 100 mumol isoprenaline, Gpp(NH)p and forskolin, respectively, in presence of an ATP-regenerating system. The determination of cAMP formed was carried out by means of a radioassay. The observed significant 50% reduction in basal as well as in stimulated adenylate cyclase activity in Alzheimer's disease is negatively correlated with semiquantitative evaluations of amyloid pla…
Identification of an Unknown Corpse by Means of Computed Tomography (CT) of the Lumbar Spine
1995
For the first time, a case is described in which an unknown corpse is identified by the comparison of antemortem and postmortem computed tomographic (CT) images. A posterolateral disc herniation at L5-S1 on the right side, Schmorl's nodes and a lucency in the ilium were found in identical locations in each case. Additionally there were characteristic morphological similarities in the vertebral bodies, spinous processes, transverse processes and neural arches. In CT identification, as in conventional radiographic identification, one must try to reproduce comparable scanning conditions and images because apparent differences in the roentgenological morphology can occur as a result of differen…
Physical activity, aerobic fitness, and brain white matter : Their role for executive functions in adolescence
2020
Highlights • Aerobic fitness level, but not physical activity, is related to white matter properties in the brain. • The relation between physical activity and working memory is moderated by fractional anisotropy (FA) of the corpus callosum. • The FA of the corpus callosum and superior corona radiata moderates the relation between aerobic fitness and working memory.
Early serum creatinine changes and outcomes in patients admitted for acute heart failure: the cardio-renal syndrome revisited.
2017
Background: The changes in renal function that occurred in patients with acute decompensated heart failure (ADHF) are prevalent, and have multifactorial etiology and dissimilar prognosis. To what extent the prognostic role of such changes may vary according to the presence of renal insufficiency at admission is not clear. Accordingly, we sought to determine whether early creatinine changes (Cr) (admission to 48-72 hours) had an effect on 1-year mortality relative to the presence of renal insufficiency at admission. Methods: We included 705 consecutive patients admitted with the diagnosis of ADHF. Admission renal insufficiency was defined as serum creatinine 1.4mg/dl (A-RIcr) or estimated gl…
Inferences on Sicilian Mesolithic subsistence patterns from cross-sectional geometry and entheseal changes
2020
International audience; Using cross-sectional geometry (CSG), entheseal changes (ECs), and presence of external auditory meatus exostosis (EAE), this study tests hypothesis-bases on isotopic and zooarchaeological evidence-that in the Sicilian Mesolithic terrestrial rather than marine resources were predominantly exploited, in substantial continuity with previous Epigravettian hunters. Results show similarities in the general frequency of ECs-a rough proxy for overall activity-with Late Pleistocene hunters, in contrast with Mesolithic coastal foragers or Neolithic herders/farmers. Yet, CSG suggests that this possible continuity in the type of resources exploited was accompanied by a behavior…
Late Pleistocene (MIS 3-4) climate inferred from micromammal communities and δ18O of rodents from Les Pradelles, France.
2013
The middle Paleolithic stratigraphic sequence of Les Pradelles (Charente, France) spans from the end of Marine Isotope Stage (MIS) 4 until the middle of MIS 3. Micromammal remains are present in all the stratigraphic levels, offering a rare opportunity to address the questions of both environmental and climatic fluctuations throughout this period. Climate modes were studied through the taphonomy, biodiversity and oxygen isotope compositions of phosphate (δ18O p ) from 66 samples of rodent tooth enamel. The δ18O p values from the lower sedimentary levels provide summer mean air temperatures of 19 ± 2°C (level 2/1) and of 16 ± 2°C (levels 2A, 2B and 4A). Within the middle of sequence (level 4…
A stalactite record of four relative sea-level highstands during the Middle Pleistocene Transition
2017
International audience; Ice-sheet and sea-level fluctuations during the Early and Middle Pleistocene are as yet poorly understood. A stalactite from a karst cave in North West Sicily (Italy) provides the first evidence of four marine inundations that correspond to relative sea-level highstands at the time of the Middle Pleistocene Transition. The speleothem is located ∼97 m above mean sea level as result of Quaternary uplift. Its section reveals three marine hiatuses and a coral overgrowth that fixes the age of final marine ingression at 1.124 ± 0.2, thus making this speleothem the oldest stalactite with marine hiatuses ever studied to date. Scleractinian coral species witness light-limited…
Preservation of modern and mis 5.5 erosional landforms and biological structures as sea level markers: A matter of luck?
2021
The Mediterranean Basin is characterized by a significant variability in tectonic behaviour, ranging from subsidence to uplifting. However, those coastal areas considered to be tectonically stable show coastal landforms at elevations consistent with eustatic and isostatic sea level change models. In particular, geomorphological indicators—such as tidal notches or shore platforms—are often used to define the tectonic stability of the Mediterranean coasts. We present the results of swim surveys in nine rocky coastal sectors in the central Mediterranean Sea using the Geoswim approach. The entire route was covered in 22 days for a total distance of 158.5 km. All surveyed sites are considered to…
Bioengineering Materials for Environment Protection in a Changing Climate
2019
Climate change is one of the biggest problems of our times and passing the time climate extremes tend to increase both in magnitude and in frequency. Because the severity of the extreme climate events has increased, the interaction of these events with vulnerable human and natural systems has more frequently lead to disasters. Recent climate models projections have also shown a further substantial warming in temperature extremes by the end of the 21st century. The prevision models’ results also indicate that the global warming and the increase in frequency of temperature extremes could be strictly related to the anthropogenic forcing. The present special issue collects contributions represe…
Effect of finishing and polishing systems on the surface roughness and color change of composite resins
2020
Background This study is to examine the surface roughness and color changes occurring on composite resins following the application of different finishing and polishing systems. Material and Methods In our study, a total of 200 samples were prepared from composites resin (6×2 mm) containing supra-nano, submicron hybrid, nanohybrid, nano-ceramic and microhybrid filler. They were polished with diamond, aluminum oxide, silicon carbide finishing and polishing systems. The initial color values of composite samples were measured with a spectrophotometer and surface roughness values with a profilometer. After that, samples were immersed of coffee solution and color measurements were repeated on th…