Search results for "chemin"
showing 10 items of 58 documents
Hierarchical Mass Transfer Analysis of Drug Particle Dissolution, Highlighting the Hydrodynamics, pH, Particle Size, and Buffer Effects for the Disso…
2020
Dissolution is a crucial process for the oral delivery of drug products. Before being absorbed through epithelial cell membranes to reach the systemic circulation, drugs must first dissolve in the human gastrointestinal (GI) tract. In vivo and in vitro dissolutions are complex because of their dependency upon the drug physicochemical properties, drug product, and GI physiological properties. However, an understanding of this process is critical for the development of robust drug products. To enhance our understanding of in vivo and in vitro dissolutions, a hierarchical mass transfer (HMT) model was developed that considers the drug properties, GI fluid properties, and fluid hydrodynamics. T…
Quelle "citoyenneté industrielle" à la SNCF ? Premiers éléments
2019
International audience; Dans un contexte de transformation des règles de représentation syndicale et de la négociation collective, de reconfiguration des institutions représentatives du personnel, d’évolutions et de débats concernant la participation de représentants des salariés au sein des conseils d’administration et, plus au fond, d’évolution de la sociologie et du débat syndical mais aussi de réformes ferroviaires récurrentes, touchant notamment au statut du personnel, il est proposé d’examiner comment dans une entreprise, telle la SNCF, certains acteurs – en l’occurrence les organisations syndicales – mais aussi le (célèbre) « statut » du personnel appréhendent (ou pas) cette notion d…
De la régionalisation à la concurrence régulée. Analyse économique et juridique de la future organisation du transport ferroviaire régional de voyage…
2006
This paper deals with the introduction of competition for the market in French regional passenger railways. Following a double approach through economics and law, it discusses the proposals for a European regulation on public passenger transport services. In a first part, the paper explains the interest and limits of competition for the market concerning French regional rail services. After analyzing the German and Swedish cases, it proposes a way of introducing competition for the market in France. In a second part, structural reforms needed ex ante are analyzed: open access to stations, rolling stock availability and future of rail employees. For each reform, the theoretical analysis is f…
A Large-Scale Empirical Evaluation of Cross-Validation and External Test Set Validation in (Q)SAR.
2013
(Q)SAR model validation is essential to ensure the quality of inferred models and to indicate future model predictivity on unseen compounds. Proper validation is also one of the requirements of regulatory authorities in order to accept the (Q)SAR model, and to approve its use in real world scenarios as alternative testing method. However, at the same time, the question of how to validate a (Q)SAR model, in particular whether to employ variants of cross-validation or external test set validation, is still under discussion. In this paper, we empirically compare a k-fold cross-validation with external test set validation. To this end we introduce a workflow allowing to realistically simulate t…
Quels apports des modèles de management stratégique à l'analyse de la compétitivité du chemin de fer ?
2018
National audience; La SNCF polarise régulièrement l'actualité économique, sociale et politique. Elle a connu en 2018 une nouvelle réforme qui l'a plongée dans plusieurs mois de crise. Plus largement, c'est l'ensemble des chemins de fer européens qui ont fait l'objet de réformes. Associant universitaires, consultants et syndicalistes, ce livre fait le point sur les évolutions récentes de ce mode de transport dans différents pays : Allemagne, Espagne, France, Italie, Royaume-Uni, Suisse. Il s'intéresse aux modalités d'ouverture à la concurrence et à leurs résultats, à l'économie et aux performances des compagnies, au devenir et aux enjeux du fret, aux statuts des personnels, au management de …
Impacts des premiers pas dans la vie active
2001
International audience; Les débuts dans la vie active peuvent-ils être prédictifs de la suite du cheminement professionnel ? Il s'avère que les caractéristiques individuelles ou de formation des jeunes, et les premiers pas sur le marché du travail, influencent la situation professionnelle à moyen terme (nature du contrat et qualification de l'emploi) des sortants des lycées techniques et professionnels de Bourgogne. Could the beginnings of professional life predict the future of professional itinerary ? The young people's individual or training characteristics, and the first steps on the labour market, proved to influence the professional situation in medium-term (the type of contract and q…
USEDAT: USA-Europe Data Analysis Training Worldwide Program, 2019 ed.
2019
USA-Europe Data Analysis Training School (USEDAT) is a Multi-center Trans-Atlantic initiative offering hands-on training focused in both Introduction to Experimental Data Recording (NMR, MS, IR, 2DGE, EEG, etc.) and/or posterior Computational Data Analysis (Machine Learning, Complex Networks, etc.). We made emphasis on applications in for Cheminformatics, Bioinformatics, Medicinal Chemistry, Nanotechnology, Systems Biology, Biomedical Engineering, etc. The school also promotes training and knowledge of ethical and legal regulatory issues (GDPR, REACH, OECD, FDA, etc.) about data use and data protection in chemistry and biomedical research. The school is directed to researchers and students …
Synthesis and antibacterial activities of cadiolides A, B and C and analogues
2015
International audience; The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.
A FRET-based probe for fluorescence sensing of sulfide/sulfite analytes, using a novel long-wavelength water-soluble 7-hydroxycoumarin as report…
2015
International audience; A FRET-based fluorescent probe for the detection of sulfide and/or sulfite in aqueous buffer, was constructed by connecting the quencher moiety nitrobenzofurazan (7-nitro-1,2,3-benzoxadiazole, NBD) to a water-soluble 3-(2-benzimidazolyl)-7-hydroxycoumarin carboxylic acid through a piperazine linker. This probe exhibits good selectivity and high sensitivity for sulfite and sulfide over cysteine and other potential analytes. Furthermore, this is one of the few examples of fluorogenic coumarins whose solubility in water is maintained upon its conversion into reaction-based fluorescent probes.
L’habitat et la nécropole du Haut Moyen Âge du lieu-dit Le Moulin Vaquet à Honguemarre-Guenouville (Eure) : un « village prénormand » du plateau du R…
2010
Sur le plateau du Roumois, le lieu-dit Moulin Vaquet à Honguemare-Guenouville (Eure) était occupé entre le VIIe et le Xe siècle par un village, habitat rural polarisé autour d’une nécropole probablement dominée par une église de bois. La fouille de ce site par la MADE sur 8 600m2 complète celle de l’INRAP à quelques centaines de mètres. Between the 7th and 10th centuries, the “Moulin Vaquet"site, near Honguemare-Guenouville (Eure) on the Roumois Plateau, was occupied by a village – a rural settlement built around a necropolis, likely dominated by a wooden church. The 8,600m2 excavation of the site run by MADE (the Eure archaeological mission) complements the INRAP excavations a few hundred …