Search results for "childhood trauma"

showing 8 items of 18 documents

Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway

2022

AbstractBackgroundThere is evidence that environmental and genetic risk factors for schizophrenia spectrum disorders are transdiagnostic and mediated in part through a generic pathway of affective dysregulation.MethodsWe analysed to what degree the impact of schizophrenia polygenic risk (PRS-SZ) and childhood adversity (CA) on psychosis outcomes was contingent on co-presence of affective dysregulation, defined as significant depressive symptoms, in (i) NEMESIS-2 (n = 6646), a representative general population sample, interviewed four times over nine years and (ii) EUGEI (n = 4068) a sample of patients with schizophrenia spectrum disorder, the siblings of these patients and controls.ResultsT…

RiskMultifactorial InheritancePsychosisHallucinationsAffective pathwayCLINICAL PSYCHOSISNEGATIVE SYMPTOMSDelusions03 medical and health sciences0302 clinical medicineMENTAL-HEALTH SURVEYchildhood adversityAffective dysregulationHumansMedicinegeneticspsychosisGenetic riskApplied Psychology1ST EPISODE PSYCHOSISGENERAL-POPULATIONbusiness.industryPSYCHIATRIC-DISORDERSSHORT-FORMAbsolute risk reductionNETWORK APPROACHIdeationmedicine.diseaseCHILDHOOD TRAUMA030227 psychiatryPsychiatry and Mental healthPsychotic DisordersSchizophreniaSchizophreniaSCHIZOPHRENIA SPECTRUM DISORDERSPolygenic risk scorebusinessenvironment030217 neurology & neurosurgerySchizophrenia spectrumClinical psychologyPsychological Medicine
researchProduct

Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis

2023

The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme.

SCHIZOPHRENIA SPECTRUMmedicine.medical_specialtyGENESpolygenic riskfirst-episode psychosiILLNESSinteraction contrast ratioChildhood traumaDOPAMINEFirst episode psychosisSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.MALTREATMENTMedicinefirst-episode psychosisABUSEPsychiatrySettore MED/25 - PsichiatriaApplied PsychologyTRAUMAENVIRONMENTbusiness.industrymedicine.diseaseschizophreniaPsychiatry and Mental healthSchizophreniaRELIABILITYPolygenic risk scoresynergistic effectsbusinessPsychological medicine
researchProduct

White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?

2019

Supported by the European Community’s Seventh Framework Program under grant agreement No. HEALTH-F2-2009-241909 (Project EU-GEI)

SYMPTOMSCommunity Assessment of Psychic ExperiencesPsychotic disorder0302 clinical medicinecognitive abilitylcsh:PsychiatrySCHIZOPHRENIASalut mentalOriginal Researchmedia_commonPsychiatryCognitive abilityCognition16. Peace & justiceCHILDHOOD TRAUMAPsychiatry and Mental healthSchizophreniaRELIABILITYTraitHALLUCINATIONSClinical psychologyInfàncialcsh:RC435-571media_common.quotation_subjectIllusionQUESTIONNAIREPsicosiLife events03 medical and health scienceschildhood adversityTHREATENING EXPERIENCESmedicinePsiquiatriaSiblingVALIDITYAssociation (psychology)White noise speech illusionsENVIRONMENTwhite noise speech illusionsbusiness.industrySHORT-FORMPsychosesOdds ratiopsychotic disordermedicine.diseaseChildhoodConfidence interval030227 psychiatrylife eventsTrastorns de la parlaChildhood adversitybusiness030217 neurology & neurosurgery
researchProduct

Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: results from the…

2021

European Community's Seventh Framework Program, European Commission [HEALTH-F2-2009-241909]; Scientific and Technological Research Council of Turkey, 2219 International Postdoctoral Research Fellowship Program; Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, and PI19/024)...

cannabisPsychosisExposomeSYMPTOMSGlobal Assessment of Functioning1ST EPISODEGENETIC RISKVALIDATIONfunctioning03 medical and health sciences0302 clinical medicineCovariatemedicineHumanspsychosisPsiquiatriaPOPULATIONchildhood traumabiologybusiness.industryGLOBAL ASSESSMENTSiblingsRegression analysisEnvironmental exposuremedicine.diseasebiology.organism_classification3. Good health030227 psychiatryPsychiatry and Mental healthExposomeCross-Sectional StudiesPsychotic DisordersSchizophreniaRELIABILITYSchizophreniaCannabisCANNABIS USE DISORDERSbusinessenvironment030217 neurology & neurosurgeryClinical psychologyResearch Article
researchProduct

THE ROLE OF CHILDHOOD TRAUMA AND COGNITIVE DEFICIT IN MODERATING THE RISK FOR PSYCHOTIC DISORDERS: A COMPARISON BETWEEN PALERMO AND SOUTH-EAST LONDON…

2011

childhood trauma; cognitive deficit; psychosischildhood traumapsychosiscognitive deficit
researchProduct

Bērnības traumatiskas pieredzes un riska uztveres saistība cilvēkiem ar tetovējumiem un tetovēšanās motivācija

2021

Pētījuma mērķis bija noskaidrot, vai pastāv atšķirības starp bērnības traumatisku pieredzi un riska uztveri cilvēkiem ar tetovējumiem un cilvēkiem bez tetovējumiem, vai pastāv saistība starp bērnības traumatisku pieredzi un riska uztveri cilvēkiem ar tetovējumiem un kāda ir tetovēšanās motivācija un pieredze. Pētījumā piedalījās 147 respondenti vecumā no 19 līdz 59 gadiem, dalībnieku ar tetovējumiem izlasē piedalījās 55 respondenti (45 sievietes un 10 vīrieši) un dalībnieku bez tetovējumiem izlasē piedalījās 92 respondenti (76 sievietes un 16 vīrieši). Pētījuma dalībnieki aizpildīja Riska uztveres aptauju (Domain-Specific Risk-Taking Scale, DOSPERT), Bērnības traumas aptauju (Childhood Trau…

childhood traumatic experienceriska uztvererisk perceptionPsiholoģijabērnības traumatiska pieredzetetovēšanās motivācija
researchProduct

Traumatiskās bērnības pieredzes saistība ar indivīda subjektīvo labklājību un dzīvesspēku

2018

Šī darba mērķis ir noskaidrot saistību starp traumatisku bērnības pieredzi un psiholoģiskās labklājības līmeni,dzīvesspēku, kā arī to veicinošiem faktoriem. Darba ietvaros traumatiska bērnības pieredze tiek apskatīta kā fiziska, emocionāla vai seksuāla vardarbība pret bērnu ģimenē. Vardarbība pret bērniem ir nozīmīga problēma ar dažāda veida nopietnām paliekošām sekām, kas ietekmē tai skaitā arī indivīda subjektīvo labklājību pieaugušo vecumā. Labklājība ir saistīta ar kognitīvu stabilitāti par abstraktām lietām un notikumiem katra cilvēka dzīvē. Apmierinātība ar dzīvi ir nozīmīgs subjektīvās labklājības komponents, vai arī zinātnisks termins vārdam „laime”(Yang& Padmini2016). Viens no labk…

dzīvesspēkspsiholoģiska labklājībapsychological well-beingPsiholoģijatraumatiska bērnības pieredzechildhood trauma experience
researchProduct

Childhood maltreatment and clinical severity of treatment‐resistant depression in a French cohort of outpatients (FACE‐DR): One‐year follow‐up

2020

International audience; Childhood maltreatment is associated with major depressive disorder (MDD). It not only increases the risk of lifetime MDD, but it also aggravates its course. Among depressed patients, 20-30% of them experience treatment-resistance depression (TRD). We aimed to assess the association between childhood maltreatment, severity of depression in a unipolar TRD sample, and patient outcomes after one-year of follow-up. Methods: Patients were recruited for a prospective cohort from the French network of TRD expert centers. Depressive symptom severity was assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology se…

medicine.medical_specialtyDepressive disordersMESH: DepressionPopulationMESH: Depressive Disorder MajorPoison controlChildhood trauma03 medical and health sciences0302 clinical medicineInternal medicineSurveys and QuestionnairesMESH: ChildOutpatientsmedicineHumansChild AbuseProspective StudiesMESH: Surveys and QuestionnaireseducationProspective cohort studyChildChildhood neglecteducation.field_of_studyDepressive Disorder Major[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/PediatricsMESH: Humansbusiness.industryDepressionAntidepressant responseChildhood abuseCTQ treeMESH: Follow-Up StudiesMESH: Child Abusemedicine.diseaseMESH: Prospective Studies3. Good health030227 psychiatryMESH: OutpatientsPsychiatry and Mental healthClinical PsychologySexual abuse[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthCohortMajor depressive disorderTreatment-resistant depressionbusinessTreatment-resistant depression030217 neurology & neurosurgeryFollow-Up Studies
researchProduct