Search results for "children"
showing 10 items of 1661 documents
Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoG…
2019
This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Avalglucosidase alfa was well-tolerated; no deaths…
Association between passive tobacco exposure and caries in children and adolescents. A systematic review and meta-analysis.
2017
To examine the available evidence on the association between exposure to tobacco use in the womb and in infancy and the presence of caries in primary and permanent dentition in children and adolescents. A systematic review was conducted through searches in 4 data bases (Pubmed, Scopus, Embase and Web of Science), complemented by hand-searching. Of the 559 articles identified, 400 were duplicates. Finally, 28 articles were included in the qualitative review and 21 in the meta-analysis. Their quality was assessed using the Newcastle-Ottawa scale. The quality was medium in 44% of the articles included and high in 56%. The overall meta-analysis gave a significant odds ratio (OR = 1.53, 95% conf…
Īss ieskats bērnu literatūras apbalvošanas fenomenā un Astrīdas Lindgrēnes piemiņas balvas (ALMA) specifikā. ALMA Latvijas grāmatizdošanas kontekstā
2021
Vēsturiski bērnu literatūras balvas ir izveidotas, lai uzlabotu bērnu literatūras kvalitāti un veicinātu bērnu grāmatu patēriņu. Mūsdienās tās var uzskatīt par socio-politisku spēli, ar mērķi novērtēt, leģitimizēt un dalīties idejām un vērtībām, kas kādai no sabiedrībām ir būtiskas. Darbā ir pievērsta uzmanība apbalvošanas fenomenam no dažādām perspektīvām, kā arī aplūkotas bērnu literatūras apbalvošanai raksturīgākās iezīmes. Īpaša uzmanība pievērsta Astrīdas Lindgrēnes piemiņas balvas (ALMA) specifikai, nominēšanas detaļām, laureātu un kandidātu analīzei, kā arī ALMA balvai grāmatizdošanas kontekstā Latvijā, un tiek pētīta tās popularitāte bibliotekāru vidū.
From sin to the civil order, unions outside of marriage under the law (XVI-XX century)
2011
The aim of this thesis is to understand the legal status of unmarried couples, over a period of time extending for nearly five centuries. The canon law of marriage relegated cohabitation to a permanent state of sin, and in the sixteenth century, the council of Trent prescribed severe penalties to punish cohabitation. The fathers of the council enacted rules governing the celebration of marriage. Secular authority then gradually arrogated jurisdiction in matrimonial matters by means of laws and jurisprudence. The line between marriage and cohabitation was now strictly drawn. Although the old law did not consider cohabitation as a crime, it castigated children born outside of wedlock by subje…
Social Emotional Competence, Learning Outcomes, Emotional and Behavioral Difficulties of Preschool Children: Parent and Teacher Evaluations
2022
This paper addresses the role of social emotional competence in the emotional and behavioral problems and learning outcomes of preschool children based on their parents’ and teachers’ evaluations. In this study, we compared the perceptions of teachers and parents when evaluating the same child using the multi-informant assessment. First, the associations and differences between both the informant evaluations were investigated. Second, the correlation of the social emotional competence and emotional, and behavioral difficulties among preschool children was analyzed, separately addressing their parents’ and teachers’ evaluations. Third, the role of the preschool children’s social emotional co…
Association between family environment and the bullying phenomenon among school-age children: A systematic review
2019
There is a lack of evidence about the possible role of the family environment in the occurrence of the bullying phenomenon among school-age children. We carried out a systematic review of the literature to investigate the positive and negative family determinants associated with the bullying phenomenon. Potential classes of determinants-e.g. interparental conflict and/or parenting behaviours-were studied by searching peer-reviewed literature published between the January 2008 and December 2018 on PubMed/MEDLINE, SCOPUS and ISI Web of Science. At the end of the eligibility process, only 3 studies met all the inclusion criteria, and were then included in the narrative synthesis. Mother destru…
Patterns of weight cycling in youth Olympic combat sports: a systematic review
2022
Abstract Background Patterns of weight cycling in adult combat sports have been extensively studied, yet data on this matter in youth combat athletes is rather scarce. Methods PubMed, EBSCOhost and Web of Science were used to retrieve relevant data. Eligible studies had to record the methods used to elicit rapid weight loss (RWL) and/or record the oscillations in bodyweight during the RWL phase. Only studies conducted in the context of an official competition were considered for inclusion in the present review. Results RWL is highly prevalent in children and adolescent combat athletes, ranging from 25 to 94% depending on the type of combat sport, age and level of competition. These athletes…
Pasaku izmantošanas iespējas 4 - 5 gadus vecu bērnu uzvedības uzlabošanai
2017
Diplomdarba “Pasaku izmantošanas iespējas 4 – 5 gadus vecu bērnu uzvedības uzlabošanai” mērķis ir izpētīt pasaku izmantošanas iespējas 4 – 5 gadus vecu bērnu uzvedības problēmu mazināšanā. Darba teorētiskā daļa satur informāciju par pētījuma problemātiku, empīriskā daļa atspoguļo sākotnējo uzvedības problēmu biežumu grupā X un pasaku ietekmi uz bērniem, atklājot pasaku izmantošanas iespējas. Pētījuma uzdevumi ir: analizēt teorētisko literatūru par pētījuma problemātiku; analizēt bērnu literatūru un radīt pasakas, kas atstātu pozitīvu iespaidu uz bērnu uzvedību; veikt empīrisku pētījumu par pasaku izmantošanas iespējām 4 – 5 gadus vecu bērnu uzvedības problēmu mazināšanā. Izvirzītā hipotēze …
Imigrantu Integrācija. Trešo kultūru bērni: Latvija un Vācija
2015
Arvien vairāk ģimeņu migrē, kļūstot par globāliem nomadiem un attīstot transnacionālu identitāti. Tāpēc lielāka uzmanība jāpievērš imigrantu bērniem, jo īpaši gados jaunāki cilvēki kļūst par trešās kultūras bērniem. Tā ir kultūra, kas ir atšķirīga no dzimtās zemes un mītnes zemes kultūras. Latvijā un Vācijā ir līdzīga problēma – izglītības sistēma nav pietiekami adaptēta imigrantu bērniem. Maģistra darba mērķis ir izpētīt konceptu „trešās kultūras bērni” un pieejamo informāciju par tešo valstu bērnu integrāciju abās valstīt, piemērojot kvalitatīvo pētniecības metodi, lai apkopotu un analizētu datus. Latvija un Vācija nesen sāka izstrādāt integrācijas politiku, lielāku uzmanību pievēršot pie…
The discovery of plant biodiversity by children through the animated movies: Alice in Wonderland
2015
The discovery of biodiversity in childs occurs through various channels: either through direct contact with the outside world, and indirectly through paintings, games and the media. Since 1937, Walt Disney Animation Studios realized animated movies inspired from novels. The first feature film was “Snow White and the Seven Dwarfs”. Since this, Disney’s studios realized more than 10 dozen movies. The feature that distinguishes these works from a technical point of view is the attention to detail especially for the scene where the action takes place. Animals are often the protagonists of these stories, rarely plants. A good example of the latter is in “Alice in wonderland”, a movie distributed…