Search results for "chino"
showing 10 items of 351 documents
Extracellular non-coding RNA signatures of the metacestode stage of Echinococcus multilocularis
2020
Extracellular RNAs (ex-RNAs) are secreted by cells through different means that may involve association with proteins, lipoproteins or extracellular vesicles (EV). In the context of parasitism, ex-RNAs represent new and exciting communication intermediaries with promising potential as novel biomarkers. In the last years, it was shown that helminth parasites secrete ex-RNAs, however, most work mainly focused on RNA secretion mediated by EV. Ex-RNA study is of special interest in those helminth infections that still lack biomarkers for early and/or follow-up diagnosis, such as echinococcosis, a neglected zoonotic disease caused by cestodes of the genus Echinococcus. In this work, we have char…
Cestode parasites release extracellular vesicles with microRNAs and immunodiagnostic protein cargo.
2017
Intercellular communication is crucial in multiple aspects of cell biology. This interaction can be mediated by several mechanisms including extracellular vesicle (EV) transfer. EV secretion by parasites has been reported in protozoans, trematodes and nematodes. Here we report that this mechanism is present in three different species of cestodes, Taenia crassiceps, Mesocestoides corti and Echinococcus multilocularis. To confirm this we determined, in vitro, the presence of EVs in culture supernatants by transmission electron microscopy. Interestingly, while T. crassiceps and M. corti metacestodes secrete membranous structures into the culture media, similar vesicles were observed in the int…
Resistance against Echinostoma caproni (Trematoda) secondary infections in mice is not dependent on the ileal protein production
2016
Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode, which has been widely employed to investigate the factors determining the rejection of intestinal helminths. Protein production patterns of intestinal epithelial cells are related to the infection-induced changes that determine the course of E. caproni infections. Herein, we compare the protein production profiles in the ileum of four experimental groups of mice: control; infected; dewormed and reinfected. Worm burdens were significantly lower in secondary infections, confirming the generation of partial resistance to homologous secondary infections in mice. However, quantitative comparison by 2D-DIGE showed that …
Mitigating anticipated effects of systematic errors supports sister-group relationship between Xenacoelomorpha and Ambulacraria.
2019
International audience; Xenoturbella and the acoelomorph worms (Xenacoelomorpha) are simple marine animals with controversial affinities. They have been placed as the sister group of all other bilaterian animals (Nephrozoa hypothesis), implying their simplicity is an ancient characteristic ]; alternatively, they have been linked to the complex Ambulacraria (echinoderms and hemichordates) in a clade called the Xenambulacraria , suggesting their simplicity evolved by reduction from a complex ancestor. The difficulty resolving this problem implies the phylogenetic signal supporting the correct solution is weak and affected by inadequate modeling, creating a misleading non-phylogenetic signal. …
Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets
2017
Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA) regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp), multi drug-resistance-related proteins (MRPs), breast cancer resistance protein (BCRP,…
Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses
2020
AbstractInterleukin-25 (IL-25) is recognized as the most relevant initiator of protective Th2 responses in intestinal helminth infections. It is well known that IL-25 induces resistance against several species of intestinal helminths, including the trematode Echinostoma caproni. E. caproni has been extensively used as an experimental model to study the factors determining the resistance to intestinal infections. Herein, we assessed the role of IL-25 in the generation of resistance in mice to E. caproni infections. ICR mice are permissive hosts for E. caproni in which chronic infections are developed in relation to the lack of IL-25 production in response to primary infection and the consequ…
Analyse historique du concept de performance en Chine. Un regard occidental
2015
A historical analysis of the concept of Performance in China. A Western lectureWe base our work on an historical study of the concept of performance in China. We postulate from a literature review that organizations and their managers are strongly influenced by cultural and institutional determinants. As a result, we present these determinants that enable us to justify several hypotheses about Chinese managers’ behaviors. In this article, we show the disappearance of Confucian values behind a combination of pragmatism, interpersonal relations and influence networks.
Estudio diacrónico contrastivo castellano-chino de unidades fraseológicas con mención de color
2019
La tesis trata de un estudio contrastivo diacrónico de las unidades fraseológicas castellanas y chinas. La mayoría de los estudios contrastivos de la fraseología española y de la china se efectúa desde un punto de vista semántico-pragmático, didáctica o sociolingüístico, mientras que nuestro trabajo se realiza desde un punto de vista diacrónico y no solo se limita al campo semántico-pragmático, sino que también se efectúa en el nivel gramatical. Entre las innumerables unidades fraseológicas, hemos elegido como objeto de nuestra investigación aquellas que contienen términos cromáticos. El criterio de Berlin y Kay, Basic color terms, junto con otros trabajos que se concentran específicamente …
Estudio acústico de las vocales del noreste de China y de su adquisición por parte de hablantes con castellano como L1 y catalán como L1
2020
En esta tesis se presentan el sistema vocálico del chino y las diferencias acústicas entre las vocales chinas pronunciadas por hablantes nativas del noreste de China y por participantes españolas. La tesis persigue tres objetivos: en primer lugar, introducir el sistema vocálico del chino, centrándonos en las vocales del mandarín del noreste de China para describir fonéticamente las peculiaridades de su sistema vocálico. En segundo lugar, estudiar las semejanzas y las diferencias entre el sistema vocálico del castellano, del catalán y del chino, y comparar las vocales chinas pronunciadas por hablantes nativas del noreste de China y las pronunciadas por informantes castellanohablantes y valen…
Intra-abdominal
2016
Aims To evaluate the contribution of light microscopy to detecting Candida spp infection in patients with complicated intra-abdominal infections (IAIs) admitted for acute abdomen to a quality assurance (QA)-certified surgical emergency ward. Methods We conducted a retrospective study (2008–2012) of 809 abdominal intraoperative or biopsy tissue specimens obtained from patients admitted with acute abdomen and microbiological samples positive for Candida spp. Demographic data, mortality, comorbidities, specimen type, microscopy results, special histological staining performed, antimicrobial therapy were collected and analysed. Any comments at the multidisciplinary team meeting was recorded in …