Search results for "circle"

Packing a multidisperse system of hard disks in a circular environment.

2008

We consider the problem of finding the densest closed packing of hard disks with proposed different radii in a circular environment, such that the radius of the circumcircle is minimal. With our approach, we are able to find denser packings for various problem instances than known from the literature. Both for the dynamics of the simulation and for the optimum values of the radii of the circumcircles, we find various scaling laws.

Die Schmieghyperebenen an die Veronese-Mannigfaltigkeit bei Beliebiger Charakteristik

1982

By means of linear algebra a base-free definition of a Veronese variety V(n,r) is given and also an illuminating description of its osculating primes from which can be deduced in a general form and without difficulty the phenomena of degeneracy in case of small characteristics. (Instance best known: For characteristic 2 all tangents of a conic are confluent.) The last section investigates special problems for the V(1,r) in characteristic p: So the osculating primes of a V(1,p) intersect its node in a V(1,p-2). Furthermore it becomes clearer why for 2<r<¦K¦−1 no elation can fix a V(1,r) (in case of a perfect field).

DEVELOPMENT OF S/MAR MINICIRLES VECTOR FOR PERSISTENT EXPRESSION IN VIVO.

2009

An ideal vector for gene therapy must fulfil the following requirements: non-toxicity, mitotic stability and persistent therapeutic levels of transgene expression. Viral vectors are widely used due to their ability to sustain prolonged expression. Their potentially tumorigenic effects are a limiting factor for in vivo applications. Non-viral vectors, which can be designed to be free from viral sequences, are a promising alternative for gene transfer although they often produce transient transgene expression. This limitation of this vector type is primarily due to bacterial sequences they contain and these have proven to be toxic for the mammalian cells as they contain a high number of unmet…

Development of a new S/MAR containing Minicircle DNA vector: a new promise for Gene Therapy.

2009

A barrier limiting the use of nonviral vectors for gene therapy is related to the short duration of transgene expression in vivo. Development, evaluation, and optimisation of a long term transgene expression using a non viral vector is currently the primary aim in our research field. Recently, we have demonstrate that a nonviral episomal plasmid (pDNA) vector combined with a scaffold/matrix attachment region (S/MAR) is able to sustain long-term expression in murine liver for at least six months following hydrodynamic injection. However, plasmids contain sequences, which are essential for propagation in bacteria but are unnecessary for expression in mammalian cells. These bacterial component…

Poligono di Willis e perdite per mescolanza

2008

Computing the Arrangement of Circles on a Sphere, with Applications in Structural Biology

2009

International audience; Balls and spheres are the simplest modeling primitives after affine ones, which accounts for their ubiquitousness in Computer Science and Applied Mathematics. Amongst the many applications, we may cite their prevalence when it comes to modeling our ambient 3D space, or to handle molecular shapes using Van der Waals models. If most of the applications developed so far are based upon simple geometric tests between balls, in particular the intersection test, a number of applications would obviously benefit from finer pieces of information. Consider a sphere $S_0$ and a list of circles on it, each such circle stemming from the intersection between $S_0$ and another spher…

Uniform, Sobolev extension and quasiconformal circle domains

1991

This paper contributes to the theory of uniform domains and Sobolev extension domains. We present new features of these domains and exhibit numerous relations among them. We examine two types of Sobolev extension domains, demonstrate their equivalence for bounded domains and generalize known sufficient geometric conditions for them. We observe that in the plane essentially all of these domains possess the trait that there is a quasiconformal self-homeomorphism of the extended plane which maps a given domain conformally onto a circle domain. We establish a geometric condition enjoyed by these plane domains which characterizes them among all quasicircle domains having no large and no small bo…

Harnessing soft innovation resources leads to neo open innovation

2019

Advancement of the digital economy has transformed the concept of the growth crossover in nations and firms, both concerning input and output. Advanced economies have been confronting a dilemma between input increases and output decreases. Contrary to traditional expectations, excessive increase in input has resulted in a productivity decline in output. A solution to this dilemma can only be expected by harnessing the vigor of soft innovation resources that lead to neo open innovation in the digital economy. This paper attempts to demonstrate this hypothetical view. Based on an empirical analysis of the development trajectories of 140 countries and 500 global ICT firms, dynamism, resulting …

Co-evolution of three mega-trends nurtures un-captured GDP – Uber's ride-sharing revolution

2016

Uber used a disruptive business model driven by digital technology to trigger a ride-sharing revolution. The institutional sources of the company’s platform ecosystem architecture were analyzed to explain this revolutionary change. Both an empirical analysis of a co-existing development trajectory with taxis and institutional enablers that helped to create Uber’s platform ecosystem were analyzed. The analysis identified a correspondence with the “two-faced” nature of ICT that nurtures un-captured GDP. This two-faced nature of ICT can be attributed to a virtuous cycle of decline in prices and an increase in the number of trips. We show that this cycle can be attributed to a self-propagating …

Explaining the relationship between socially responsible products and the operations of the firm: The case of equine assisted therapy

2018

Abstract Although there is a growing interest in social responsibility in research as well as in practice, the majority of studies on corporate social responsibility do not explicitly investigate operations management issues when adopting socially responsible practices under the “people” pillar of sustainability. This paper, dealing with the theme of social responsibility in operations management, aims at clarifying the complex relationship between socially responsible product/service and the operations of the company. The empirical context of the study is the sport industry, where the attention to social issues is well established. We used a mixed theoretical-empirical approach to develop …