Search results for "circular"
showing 10 items of 856 documents
Interaction of metal ions with N-glycosylamines: isolation and characterization of the products of 4,6-O-benzylidene-N-(o-carboxyphenyl)-β-D-glucopyr…
2001
Metal-ion complexes of Li+, Na+, K+, Mg2+, Ca2+, Ba2+, Pb2+, Cd2+, Hg2+ with 4,6–O–benzylidene–N–(o–carboxyphenyl)–β–D–glucopyranosylamine were synthesized and isolated as solid products and characterized by analytical means as well as by spectral techniques, such as, 1H and 13C NMR, FTIR, absorption, FAB mass spectrometry, optical rotation and CD. While the alkali metal ions formed ML type of complexes, the other metal ions formed ML2 type complexes. Molecular weights of the complexes of Li+, Na+ and K+ were established based on the molecular-ion peaks in the FAB mass spectra. The saccharide portion remians in the β-anomeric form even after the complexation. The spectral data, as well as t…
Turning waste into gold: Sustainable feed made of discards from the food industries promotes gonad development and colouration in the commercial sea …
2021
Abstract Development of sustainable aquaculture practices is a suitable solution to reduce the pressure on overexploited stocks of the Mediterranean sea urchin, Paracentrotus lividus, and to respond to the increasing market demand. To move forward the Blue Growth and following the principles of circular economy, a three-month feeding experiment was conducted to test a sustainable feed based on food processing discards on sea urchins. Two feed formulations differing on the proportions of the two main ingredients (endive outermost leaves and European anchovy discards in a ratio of 60:40 and 80:20 respectively) were prepared and tested on P. lividus gonad yield, development and quality. The re…
NATURALLY AVAILABLE SOLUTIONS FOR BUILDING NEW METABOLIC TERRITORIES
2021
Building new metabolic territories is a proactive way of responding to the challenges and precariousness of the contemporary city. Byintegrating solutions inspired by new scientific advances in urban ecology, cities are able to address some of the environmental threats. Many European cities are implementing alternative nature-based solutions to protect their health and tackle water scarcity, land consumption and climate change, to increase citizens' well-being. Wellbeing and health (Agenda 2030) are the most important analytical parameters for measuring the results and impacts of environmental project actions. With this in mind, the study presents a "nature-action" project hypothesis for wh…
Isolation of carcinoembryonic antigen N-terminal domains (N-A1) from soluble aggregates
2011
Abstract Carcinoembryonic antigen (CEA) was identified as a prominent tumor-associated antigen in human colorectal cancer and it is still intensively investigated. However, its physiological role remains unclear. The CEA molecule is composed of seven highly hydrophobic, immunoglobulin-like domains, six of which contain a single disulphide bridge. The production of recombinant protein containing Ig-like domains in bacterial expression systems often results in partial degradation or insolubility due to aggregation hampering the analysis of their native structure and function. Here, we present a new method of expression and purification of CEA N-terminal domains (N-A1) fused to MBP in Escheric…
Harmonic generation in all-dielectric metasurfaces
2023
Nonlinear light generation is a key phenomenon in many optical systems. Recently, the field of nonlinear optics has moved to the miniaturization of conventional bulky components. Among all the new platforms that have been proposed, dielectric nanoscale resonators represent excellent candidates for light generation and manipulation. When arranged in periodic arrays, such high refractive index scattering components become an artificial material called metasurface. Several approaches for designing platforms with enhanced optical nonlinearities at moderate pump intensities have been proposed. In this chapter, we review the most recent results on second- and third-order nonlinear processes in hi…
Revalorization of Almond By-Products for the Design of Novel Functional Foods: An Updated Review
2021
The search for waste minimization and the valorization of by-products are key to good management and improved sustainability in the food industry. The great production of almonds, based on their high nutritional value as food, especially almond kernels, generates tons of waste yearly. The remaining parts (skin, shell, hulls, etc.) are still little explored, even though they have been used as fuel by burning or as livestock feed. The interest in these by-products has been increasing, as they possess beneficial properties, caused by the presence of different bioactive compounds, and can be used as promising sources of new ingredients for the food, cosmetic and pharmaceutical industry. Additio…
Study of the Mode and Efficiency of DNA Binding in the Damage Induced by Photoactivated Water Soluble Porphyrins
2013
We have investigated the DNA binding interactions and in vitro photoactivated DNA damage induced by a neutral water soluble porphyrin derivative 5,10,15,20-tetrakis(2,4,6-trihydroxyphenyl)porphyrin (TTHPP) and its zinc derivative 5,10,15,20-tetrakis(2,4,6-trihydroxyphenyl)porphyrinato zinc(II) (Zn-TTHPP) upon visible light irradiation through various spectroscopic techniques and employing repair endonucleases. These porphyrin derivatives exhibited high affinity toward DNA through groove binding interactions as evidenced through the UV-vis absorption, emission, circular dichroism spectral and viscosity changes. Interestingly, the free base porphyrin derivative, TTHPP generated efficient sing…
Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.
2019
Objective: The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. Design: We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA (lncRNA) expressed in the liver and increased in human hepatocellular carcinoma (HCC), in the regulation of host target genes and the HBV cccDNA. Results: We show that HBx binds the promoter region, enhances the transcription and induces the accumulation of DLEU2 in infected hepatocytes. We found that nuclear DLEU2 directly binds HBx…
Spontaneous Scalarization of Charged Black Holes
2018
Extended scalar-tensor-Gauss-Bonnet (eSTGB) gravity has been recently argued to exhibit spontaneous scalarisation of vacuum black holes (BHs). A similar phenomenon can be expected in a larger class of models, which includes e.g. Einstein-Maxwell-scalar (EMS) models, where spontaneous scalarisation of electrovacuum BHs should occur. EMS models have no higher curvature corrections, a technical simplification over eSTGB models that allows us to investigate, fully non-linearly, BH scalarisation in two novel directions. Firstly, numerical simulations in spherical symmetry show, dynamically, that Reissner-Nordstr\"om (RN) BHs evolve into a perturbatively stable scalarised BH. Secondly, we compute…
Hairy black-holes in shift-symmetric theories
2020
Scalar hair of black holes in theories with a shift symmetry are constrained by the no-hair theorem of Hui and Nicolis, assuming spherical symmetry, time-independence of the scalar field and asymptotic flatness. The most studied counterexample is a linear coupling of the scalar with the Gauss-Bonnet invariant. However, in this case the norm of the shift-symmetry current $J^2$ diverges at the horizon casting doubts on whether the solution is physically sound. We show that this is not an issue since $J^2$ is not a scalar quantity, since $J^\mu$ is not a diff-invariant current in the presence of Gauss-Bonnet. The same theory can be written in Horndeski form with a non-analytic function $G_5 \s…