Search results for "cirrosi"

Overcoming a “Probable” Diagnosis in Antimitochondrial Antibody Negative Primary Biliary Cirrhosis: Study of 100 Sera and Review of the Literature

2010

Serum anti-mitochondrial antibodies (AMA) are the serological hallmark of primary biliary cirrhosis (PBC), yet up to 15% of PBC sera are AMA negative at routine indirect immunofluorescence (IIF) while being referred to as “probable” cases. The diagnostic role of PBC-specific antinuclear antibodies (ANA) remains to be determined. We will report herein data on the accuracy of new laboratory tools for AMA and PBC-specific ANA in a large series of PBC sera that were AMA-negative at IIF. We will also provide a discussion of the history and current status of AMA detection methods. We included IIF AMA-negative PBC sera (n = 100) and sera from patients with other chronic liver diseases (n = 104) th…

Valutazione combinata mediante TCMD a 64 strati e CEUS dei noduli epatici in pazienti cirrotici.

2008

Ruolo dei pattern ecografici nella sorveglianza per la diagnosi precoce dell'HCC

SCREENING DELL’EPATOCARCINOMA (HCC) NELLA CIRROSI EPATICA (CE): RUOLO DEI PATTERN ECOGRAFICI (US)

2013

Physical frailty in liver transplantation.

2020

In patients with cirrhosis, frailty represents a status of global physical dysfunction associated with a multiplicity of factors, including muscle wasting, undernutrition and malnutrition, and functional impairment. This condition is particularly prevalent among those with advanced cirrhosis, such as liver transplant (LT) candidates. Studies in this vulnerable population have demonstrated that its presence is independently predictive of adverse outcomes both pre- and post-transplantation, and thus that its incorporation into clinical practice could result in improved clinical decision-making, particularly regarding the identification of candidates for physical and nutritional interventions.…

Significato clinico di polimorfismi di geni citochinici (IL-6, TNF-ALPHA) nella cirrosi epatica e nel carcinoma epatocellulare

2009

Heart rate variability is associated with disease severity and portal hypertension in cirrhosis

2023

Introduction: Autonomic nervous system activity in cirrhotic portal hypertension is linked to hyperdynamic circulation. Heart rate variability (HRV) is a validated noninvasive method to assess the sympathovagal balance. To investigate the correlation between HRV parameters and degree of portal hypertension, we studied a cohort of patients with cirrhosis accounting for etiology and treatments. Patients and Methods: In this cross-sectional, observational cohort study, 157 outpatients of both sex with nonalcoholic cirrhosis were assessed by upper gastrointestinal endoscopy to search for esophagogastric varices. Twenty-four-hour electrocardiogram Holter monitoring with 3 HRV parameters measurem…

Desigualdades y mortalidad por cirrosis en varones (Zaragoza, 1996-2003)

2011

ResumenObjetivosAnalizar diferencias geográficas en la mortalidad por cirrosis hepática, en varones, en la provincia de Zaragoza, y su posible asociación con indicadores socioeconómicos, así como identificar la adecuación, en el ámbito rural, del índice de privación del proyecto MEDEA.MétodosLa unidad geográfica de análisis para Zaragoza capital fue la sección censal, y para el resto de la provincia el municipio. Para cada unidad de análisis se calculó la razón de mortalidad estandarizada cruda y suavizada mediante un modelo lineal generalizado mixto bayesiano. Se calculó un índice sintético de privación y se incluyó en el modelo en cuartiles. También se realizó el análisis exploratorio inc…

Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis

2016

AIM. To evaluate the effects of asymmetric dimethylarginine (ADMA) in renal arteries from portal hypertensive and cirrhotic rats. METHODS. Rat renal arteries from Sham (n = 15), pre-hepatic portal hypertension (PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis (BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA (10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide (NO) synthase. Concentration-response curves to acetylcholine (1 × 10-9-3 × 10-6 mol/L) were determined in precontracted renal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein e…

Peg-interferon alone or combined with ribavirin in HCV cirrhosis with portal hypertension:a randomized controlled trial

2007

Abstract BACKGROUND/AIMS: Risks and benefits of antiviral therapy in HCV cirrhosis with portal hypertension are poorly known. METHODS: We performed a randomized controlled trial in 102 HCV patients with compensated cirrhosis and portal hypertension: 51 received 1 microg/kg/week of Pegylated-interferon alpha-2b and 51 Pegylated-interferon plus 800 mg/day of ribavirin up to 52 weeks. RESULTS: By intention-to-treat analysis, five patients on monotherapy and eleven on combination therapy achieved a sustained virological response (9.8% vs. 21.6%, p=0.06). The response was more frequent for genotypes 2 or 3 than genotype 1 (66.6% vs. 11.3%, p=0.001). Genotype 1, who had low viral load at start of…