Search results for "clar"
showing 10 items of 728 documents
Assessment of production and qualitative characteristics of different populations of Salvia sclarea L. found in Sicily (Italy)
2021
Salvia sclarea L. is an important industrial crop, valued for its herbal-aromatic properties and high quality essential oils, that is used in food, pharmaceuticals and cosmetics. In this study, carried out from 2009 to 2010, the morphological and production characteristics and essential oil content and composition of three Sicilian populations were studied. In particular, the composition of essential oils extracted from primary and secondary inflorescences using steam distillation was assessed. Morphological, production and qualitative data from the three populations were subjected to analysis of variance and cluster analysis. Regarding the quality of the oils, only the most prevalent compo…
The role of (E)-6-chloro-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-2-styrylquinazolin-4(3H)-one in the modulation of cannabinoidergic system. A pilot stu…
2018
Abstract Background Compounds acting on endocannabinoid system regulate different neuronal processes through the cannabinoid receptors activation. The main aim of this study was determining whether the 2-styrylquinazolin-4(3H)-one 5, a structural analogue of rimonabant, was able to counteract the behavioural signs of the activation of the endocannabinoidergic system induced by CP 55.940. Methods Behavioural assessment was carried out using the tetrad task and the novel object recognition test. The endocannabinoidergic system activation was possible by the administration of CP 55.940 and 30 min after rats were tested in the tetrad task for the evaluation of the antinociceptive-, cataleptic-,…
Communication about vaccination: A shared responsibility
2016
ABSTRACT Vaccine hesitancy is an important issue to be addressed, due to the risk of decrease of vaccination coverage and consequent control of preventable diseases. While it is not considered a specific determinant, poor or inadequate communication can contribute to vaccine hesitancy and negatively influence vaccination uptake. As a contribution to the ongoing discussion regarding this theme and in the perspective of the implementation of the upcoming national vaccination plan in Italy, the Erice Declaration was drafted by experts in the field of immunization following a 5-day residential, independent workshop regarding communication topics in vaccinology. The aim of the current letter is …
Protein misfolding, amyotrophic lateral sclerosis and guanabenz: Protocol for a phase II RCT with futility design (ProMISe trial)
2017
IntroductionRecent studies suggest that endoplasmic reticulum stress may play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through an altered regulation of the proteostasis, the cellular pathway-balancing protein synthesis and degradation. A key mechanism is thought to be the dephosphorylation of eIF2α, a factor involved in the initiation of protein translation. Guanabenz is an alpha-2-adrenergic receptor agonist safely used in past to treat mild hypertension and is now an orphan drug. A pharmacological action recently discovered is its ability to modulate the synthesis of proteins by the activation of translational factors preventing misfolded protein accumula…
Computational analysis of macrolides as SARS-CoV-2 main protease inhibitors: a pattern recognition study based on molecular topology and validated by…
2021
Since the outbreak of the current SARS-CoV-2 pandemic, much has been discussed about the effectiveness of treatments based on hydroxychloroquine combined with azithromycin or another macrolide. However, few articles have dealt with the possibility of using macrolides alone in treating the disease. In the present article, the authors' hypothesis centers on the possibility that macrolides are effective against SARS-CoV-2 by inhibiting the virus protease. In support of this hypothesis, significant results are collected by following an in silico strategy based on a combination of molecular topology and docking. The results are in accordance with recent clinical data generated during the pandemi…
International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (r…
2017
Autoimmune diseases are a complex set of diseases characterized by immune system activation and, although many progresses have been done in the last 15 years, several unmet needs in the management of these patients may be still identified. Recently, a panel of international Experts, divided in different working groups according to their clinical and scientific expertise, were asked to identify, debate and formulate a list of key unmet needs within the field of rheumatology, serving as a roadmap for research as well as support for clinicians. After a systematic review of the literature, the results and the discussions from each working group were summarised in different statements. Due to th…
The nucleic acid-binding protein PcCNBP is transcriptionally regulated during the immune response in red swamp crayfish Procambarus clarkii
2016
Gene family encoding cellular nucleic acid binding proteins (CNBP) is well conserved among vertebrates; however, there is limited knowledge in lower organisms. In this study, a CNBP homolog from the red swamp crayfish Procambarus clarkii was characterised. The full-length cDNA of PcCNBP was of 1257 bp with a 5′-untranslated region (UTR) of 63 bp and a 3′-UTR of 331 bp with a poly (A) tail, and an open-reading frame (ORF) of 864 bp encoding a polypeptide of 287 amino acids with the predicted molecular weight of about 33 kDa. The predicted protein possesses 7 tandem repeats of 14 amino acids containing the CCHC zinc finger consensus sequence, two RGG-rich single-stranded RNA-binding domain an…
Toward a Theoretical Framework of Corporate Social Irresponsibility: Clarifying the Gray Zones Between Responsibility and Irresponsibility
2021
In this conceptual article, we argue that defining corporate social responsibility (CSR) and corporate social irresponsibility (CSI) as opposite constructs produces a lack of clarity between responsible and irresponsible acts. Furthermore, we contend that the treatment of the CSR and CSI concepts as opposites de-emphasizes the value of CSI as a stand-alone construct. Thus, we reorient the CSI discussion to include multiple aspects that current conceptualizations have not adequately accommodated. We provide an in-depth exploration of how researchers define CSI and both identify and analyze three important gray zones between CSR and CSI: (a) the role of harm and benefit, (b) the role of the a…
Sociología, Derecho y desigualdades sociales. Una propuesta de docencia universitaria crítica
2019
Fil: Di Nella, Dino. Universidad Nacional de Río Negro. Río Negro, Argentina. Fil: Almeda, Elisabet. Universidad de Barcelona. Catalunya, España. Fil: Camps Calvet, Clara. Universidad de Barcelona. Catalunya, España. Fil: Giordana, Patricia. Universidad Nacional de Río Negro. Río Negro, Argentina. Fil: Loggiacco, Camila. Universidad Nacional de Río Negro. Río Negro, Argentina. Fil: D'Alfonso, Luis. Universidad Nacional de Río Negro. Río Negro, Argentina. Critic education in human rights and social inequalities must be able to capture holistic and mutidmiensional sphere that Human Rights requires. This study introduces the basis in which critic university teaching proposal is carectarized by…
Presentación e ingreso de determinadas declaraciones y autoliquidaciones tributarias durante el Estado de Alarma
2020
[ES] Desde la declaración del estado de alarma como consecuencia de la crisis sanitaria provocada por el COVID-19, han sido aprobados numerosos reales decretos. Entre ellos, uno de los principales desde la perspectiva tributaria es el Real Decreto-ley 14/2020, en virtud del cual se ampliaba el plazo de presentación e ingreso de numerosos tributos, destacando, entre otros, el IVA y el IS. Además, las comunidades autónomas también han aprobado medidas relativas a la ampliación del plazo de presentación e ingreso de los tributos respecto de los que tienen atribuidas competencias.