Search results for "cluster analysis."
showing 10 items of 805 documents
KRAS mutation signature in colorectal tumors significantly overlaps with the cetuximab response signature.
2008
Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular progn…
2014
Abstract Purpose: To optimize neuroblastoma treatment stratification, we aimed at developing a novel risk estimation system by integrating gene expression–based classification and established prognostic markers. Experimental Design: Gene expression profiles were generated from 709 neuroblastoma specimens using customized 4 × 44 K microarrays. Classification models were built using 75 tumors with contrasting courses of disease. Validation was performed in an independent test set (n = 634) by Kaplan–Meier estimates and Cox regression analyses. Results: The best-performing classifier predicted patient outcome with an accuracy of 0.95 (sensitivity, 0.93; specificity, 0.97) in the validation coh…
Prognostic value of nuclear matrix protein expression in localized prostate cancer.
2012
The aim of the study was to correlate nuclear matrix (NM) protein expression profiles with the risk of PSA progression or death in early prostate cancer (PCa).High-resolution two-dimensional gel electrophoresis (2D-PAGE) was used to identify tumor-associated NM proteins in the PCa specimens obtained from 94 patients. The association between the expression of each protein and the probability of PSA progression or death was studied through univariate analysis. Unsupervised hierarchical clustering analysis was then used to generate patient clusters showing comparable outcomes by including the proteins that were predictive at univariate analysis. PSA-free and overall survival curves relative to…
Quantitative modeling of clinical, cellular, and extracellular matrix variables suggest prognostic indicators in cancer: a model in neuroblastoma
2014
BACKGROUND: Risk classification and treatment stratification for cancer patients is restricted by our incomplete picture of the complex and unknown interactions between the patient's organism and tumor tissues (transformed cells supported by tumor stroma). Moreover, all clinical factors and laboratory studies used to indicate treatment effectiveness and outcomes are by their nature a simplification of the biological system of cancer, and cannot yet incorporate all possible prognostic indicators. METHODS: A multiparametric analysis on 184 tumor cylinders was performed. To highlight the benefit of integrating digitized medical imaging into this field, we present the results of computational s…
Detection of local tourism systems by threshold accepting
2015
Despite the importance of tourism as a leading industry in the development of a country’s economy, there is a lack of criteria and methodologies for the detection, promotion, and governance of local tourism systems. We propose a quantitative approach for the detection of local tourism systems the size of which is optimal with respect to geographical, economic, and demographical criteria: we formulate the problem as an optimisation problem and we solve it by a metaheuristic approach; then we compare the obtained results with standard clustering approaches and with an exact optimisation solver. Results show that our approach requires low computational times to provide results that are better …
Combined Elephant Herding Optimization Algorithm with K-means for Data Clustering
2018
Clustering is an important task in machine learning and data mining. Due to various applications that use clustering, numerous clustering methods were proposed. One well-known, simple, and widely used clustering algorithm is k-means. The main problem of this algorithm is its tendency of getting trapped into local minimum because it does not have any kind of global search. Clustering is a hard optimization problem, and swarm intelligence stochastic optimization algorithms are proved to be successful for such tasks. In this paper, we propose recent swarm intelligence elephant herding optimization algorithm for data clustering. Local search of the elephant herding optimization algorithm was im…
Clustering local tourism systems by threshold acceptance
2015
Despite the importance of tourism as a leading industry in the development of a country’s economy, there is a lack of criteria and methodologies for the detection, promotion and governance of local tourism systems. We propose a quantitative approach for the detection of local tourism systems that are optimal with respect to geographical, economic, and demographical criteria. To this end, we formulate the issue as an optimization problem, and we solve it by means of Threshold Acceptance, a meta-heuristic algorithm which does not require us to predefine the number of clusters and also does not require all geographic areas to belong to a cluster.
A hybrid algorithm for planning public charging stations
2014
International audience; Green mobility solutions are receiving currently an enormous attention. Indeed, during last years, electric vehicles, being part of the field of the smart-grid, entered the automobile market of the whole world. This technology requires an effective deployment of charging stations of electric refill since the main problem in this system remains over the duration of refill of the batteries. In this work, we propose an optimized algorithm to locate electric charging stations. The main task of the algorithm is to find the best site of charging stations locations so as to minimize loss on the way to the charging station, as well as minimize investment cost, we take into a…
Multi-party metering: An architecture for privacy-preserving profiling schemes
2013
Several privacy concerns about the massive deploy- ment of smart meters have been arisen recently. Namely, it has been shown that the fine-grained temporal traces generated by these meters can be correlated with different users behaviors. A new architecture, called multi-party metering, for enabling privacy-preserving analysis of high-frequency metering data without requiring additional complexity at the smart meter side is here proposed. The idea is to allow multiple entities to get a share of the high-frequency metering data rather than the real data, where this share does not reveal any information about the real data. By aggregating the shares provided by different users and publishing …
Water quality sensor placement: a multi-objective and multi-criteria approach
2021
[EN] To satisfy their main goal, namely providing quality water to consumers, water distribution networks (WDNs) need to be suitably monitored. Only well designed and reliable monitoring data enables WDN managers to make sound decisions on their systems. In this belief, water utilities worldwide have invested in monitoring and data acquisition systems. However, good monitoring needs optimal sensor placement and presents a multi-objective problem where cost and quality are conflicting objectives (among others). In this paper, we address the solution to this multi-objective problem by integrating quality simulations using EPANET-MSX, with two optimization techniques. First, multi-objective op…