Search results for "cognit."
showing 10 items of 15244 documents
Olfaction, émotions et comportements
2015
International audience; Le nez a ses raisons que la raison ignore. Les émotions olfactives sont souvent inconscientes et vont pourtant diriger nombreux de nos comportements. Ce lien étroit entre émotion et olfaction est dû au fait que certaines régions cérébrales sont à la fois impliquées dans les processus olfactifs et émotionnels (cortex frontal et amygdale). Dans les pathologies neurodégénératives, dont la maladie d’Alzheimer (MA), ces structures vont être atteintes à des stades plus ou moins sévères de la maladie. Au-delà d’une aide au diagnostic précoce, nous avons montré que l’utilisation d’odorants pourrait aider au diagnostic différentiel entre certains troubles de l’humeur et la ma…
EL PAPEL DE LA AUTOESTIMA EN LA PREVENCIÓN DEL VIH DE JÓVENES ESPAÑOLES
2017
Abstract.THE ROLE OF SELF-ESTEEM IN HIV PREVENTION AMONG SPANISH YOUNG PEOPLE SELF-ESTEEM INFLUENCES ON SEXUAL DEVELOPMENT AND RELATIONSHIPS OF YOUNG PEOPLE.Aims to examine the effects of the self-esteem on HIV prevention, 467 young people from the Valencian Community (Mage = 20.62; SD = 2.14) completed the Rosenberg Self-esteem Scale and the Aids Prevention Questionnaire by Ballester et al. (2007). Results showed statistically significant positive correlation between self-esteem and self-efficacy in condom use (p = .000), perceived competence (p = .041) or number of sexual partners (p = .001). On the other hand, statistically significant negative correlation were found between solidarity t…
Pediatric Psychology
2021
The attention and the intervention of psychology in the field of pediatrics, especially regarding mothers and childcare, whether in a hospital or not, is extremely longstanding [...]
Building Robustness into Translational Research
2020
AbstractNonclinical studies form the basis for the decision whether to take a therapeutic candidate into the clinic. These studies need to exhibit translational robustness for both ethical and economic reasons. Key findings confirmed in multiple species have a greater chance to also occur in humans. Given the heterogeneity of patient populations, preclinical studies or at least programs comprising multiple studies need to reflect such heterogeneity, e.g., regarding strains, sex, age, and comorbidities of experimental animals. However, introducing such heterogeneity requires larger studies/programs to maintain statistical power in the face of greater variability. In addition to classic sourc…
Analysis of Activity States of Local Neuronal Microcircuits in Mouse Brain
2018
Time series of neuronal activity corresponding to different activity states in mouse brain are analyzed in the time domain and the time-frequency domain. The signals are associated with either a slow wave brain state or a persistent brain state. For both states, characteristic spectral features are identified and a simple detector is proposed that is able to identify the brain state with low latency and high accuracy. In practice, being able to monitor the brain state online and in real time is crucial for improved in vivoexperiments and, ultimately, for a causal understanding of brain dynamics.
Predicción del estado nutricional a través de la calidad de vida y el patrón del sueño en ancianos con deterioro cognitivo
2019
Resumen Objetivo: establecer y analizar una posible relación entre el estado nutricional, el patrón de sueño y la calidad de vida en una muestra de pacientes con disfunción cognitiva. Participantes y método: estudio observacional y descriptivo de un grupo de casos con una muestra constituida por 48 personas mayores (65 años o más) que aceptaron participar en el estudio y vivían en Valencia (España). EuroQol (EQ-5D), Cuestionario de Oviedo del sueño (COS), Mini Mental State de Folsteisn (MMSE) y Mini Nutritional Assessment (MNA) se utilizaron para evaluar el caso de cada individuo. La asociación de variables se evaluó mediante la correlación entre las tres variables. Finalmente, para verific…
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…
2016
Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…
Engineering of a DNA Polymerase for Direct m6A Sequencing
2017
Methods for the detection of RNA modifications are of fundamental importance for advancing epitranscriptomics. N6-methyladenosine (m6A) is the most abundant RNA modification in mammalian mRNA and is involved in the regulation of gene expression. Current detection techniques are laborious and rely on antibody-based enrichment of m6A-containing RNA prior to sequencing, since m6A modifications are generally "erased" during reverse transcription (RT). To overcome the drawbacks associated with indirect detection, we aimed to generate novel DNA polymerase variants for direct m6A sequencing. Therefore, we developed a screen to evolve an RT-active KlenTaq DNA polymerase variant that sets a mark for…
Mutanome directed cancer immunotherapy
2015
Somatic mutations are important drivers of cancer development. Accumulating evidence suggests that a significant subset of mutations result in neo-epitopes recognized by autologous T cells and thus may constitute the Achilles' heel of tumor cells. T cells directed against mutations have been shown to have a key role in clinical efficacy of potent cancer immunotherapy modalities, such as adoptive transfer of autologous tumor infiltrating lymphocytes and immune checkpoint inhibitors. Whereas these findings strengthen the idea of a prominent role of neo-epitopes in tumor rejection, the systematic therapeutic exploitation of mutations was hampered until recently by the uniqueness of the reperto…
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.
2020
Adult hippocampal neurogenesis was originally discovered in rodents. Subsequent studies identified the adult neural stem cells and found important links between adult neurogenesis and plasticity, behavior, and disease. However, whether new neurons are produced in the human dentate gyrus (DG) during healthy aging is still debated. We and others readily observe proliferating neural progenitors in the infant hippocampus near immature cells expressing doublecortin (DCX), but the number of such cells decreases in children and few, if any, are present in adults. Recent investigations using dual antigen retrieval find many cells stained by DCX antibodies in adult human DG. This has been interprete…