Search results for "colonic"
showing 10 items of 329 documents
TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling
2004
Alterations of TGF-beta signaling have been described in colorectal cancer, although the molecular consequences are largely unknown. By using transgenic mice overexpressing TGF-beta or a dominant-negative TGF-betaRII, we demonstrate that TGF-beta signaling in tumor infiltrating T lymphocytes controls the growth of dysplastic epithelial cells in experimental colorectal cancer, as determined by histology and a novel system for high-resolution chromoendoscopy. At the molecular level, TGF-beta signaling in T cells regulated STAT-3 activation in tumor cells via IL-6. IL-6 signaling required tumor cell-derived soluble IL-6R rather than membrane bound IL-6R and suppression of such TGF-beta-depende…
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype
2007
Abstract Background Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy), and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represe…
Dual effect of 1-deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29.
1990
International audience; 1-Deoxymannojirimycin (dMM), a specific alpha-mannosidase I inhibitor, completely blocks the conversion of Man9-8GlcNAc2 into Man7-5-GlcNAc2 in both differentiated and undifferentiated human adenocarcinoma HT-29 cells. Besides this well known effect on N-glycan trimming, we describe here a novel effect of this inhibitor on the D-[2-3H]mannose uptake that is exclusively observed in differentiated intestinal cells, i.e. cells that display a functional apical brush border membrane. This inhibition of D-[2-3H]mannose uptake was shown to be dose-dependent and reversible. Moreover, using microsomal fractions we showed that this effect depends only on the integrity of the b…
Influencia de la octreótida en la anastomosis tras obstrucción cólica experimental
2003
Resumen Introduccion Se valora el efecto de la octreotida sobre la oclusion experimental del colon y posterior anastomosis. Material y metodo Se realiza una oclusion de colon en dos grupos de ratas Wistar, a uno de los cuales se le administra octreotida. A las 48 h se relaparotomizo a los animales, se valoraron el grado de oclusion y el contenido intestinal y se reseco un fragmento intestinal para estudio histologico, confeccionando una anastomosis termino-terminal. A los 7 dias se reintervino a los animales y se valoraron las complicaciones, determinando la presion de rotura de la anastomosis, la cantidad de colageno que contiene y su histologia. Resultados El grupo tratado con octreotida …
Détection du cancer colorectal et des lésions prémalignes par chromoscopie et endoscopie à optique grossissante
2005
En Europe, le cancer colorectal (CCC) est la seconde cause de mortalite consecutive a une pathologie tumorale [1]. En depit des techniques chirurgicales eprouvees et des nouvelles formes de chimiotherapie, les tumeurs invasives, a l’exception des stades du debut, conservent encore a 5 ans des resultats de survie decevants, de l’ordre de 70 % avec envahissement metastatique proximal et seulement 6% en cas de metastase a distance [1]. Les taux de survie et de mortalite du CCR peuvent etre ameliores par une detection de cancer au debut a un stade preclinique. Par consequent, l’incidence du CCR peut etre reduite grâce a une detection endoscopique de lesions premalignes ou de cancers au debut. L…
Coloscopie virtuelle — par tomodensitométrie (CTDM) et résonance magnétique (CRM) — dans la détection des polypes coliques et des lésions néoplasiques
2005
Tant chez l’homme que chez la femme, le cancer colorectal (CCR) constitue la deuxieme cause de deces dans les pays occidentaux. Par consequent, le depistage du cancer colorectal et de ses precurseurs est un important probleme de sante publique. L’utilisation de la coloscopie par tomodensitometrie computee (CTDM) et par resonance magnetique (CRM), mieux connue sous l’appellation coloscopie virtuelle, rencontre un succes populaire croissant. Le present article a pour but de passer en revue les donnees de la litterature, d’etablir l’etat actuel de la coloscopie virtuelle, et de predire son impact potentiel sur la pratique actuelle et future en gastro-enterologie.
Dépistage et diagnostic précoce du cancer colorectal
2007
Qu’est-on en droit d’attendre d’une methode ideale de depistage et de surveillance par coloscopie? La technique doit permettre la detection d’importantes lesions mais aussi de discretes alterations muqueuses. Idealement, la distinction endoscopique entre lesion neoplasique et non neoplasique devrait etre possible en cours d’examen. Actuellement, l’endoscopie peut etre realisee avec de nouveaux endoscopes plus puissants. Parallelement au developpement rapide des puces electroniques, les caracteristiques optiques des nouveaux endoscopes offrent des resolutions qui permettent de voir de nouveaux details de la surface muqueuse. En complement de la chromo-endoscopie, les nouveaux videocoloscopes…
H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway
2014
// Marion Cortier 1, 2, 3 , Rahamata Boina-Ali 1, 2, 3 , Cindy Racoeur 1, 2, 3 , Catherine Paul 1, 2, 3 , Eric Solary 2, 4, 5 , Jean-Francois Jeannin 1, 2, 3 , Ali Bettaieb 1, 2, 3 1 EPHE, Tumor Immunology and Immunotherapy Laboratory, Dijon, F-21000, France 2 Inserm U866, Dijon, F-21000, France 3 EA7269, University of Burgundy, Dijon, F-21000, France 4 Inserm UMR1009, Gustave Roussy Institute, Villejuif F-94805, France 5 University Paris-Sud, Faculty of Medicine, Le Kremlin-Bicetre, F-94800, France Correspondence to: Ali Bettaieb, e-mail: ali.bettaieb@u-bourgogne.fr Keywords: H89, GTN, cancer, purinergic receptors, cGMP Received: October 08, 2014 Accepted: January 09, 2015 Publis…
Novel artemisinin derivatives with potential usefulness against liver/colon cancer and viral hepatitis.
2013
Antitumor and antiviral properties of the antimalaria drug artemisinin from Artemisia annua have been reported. Novel artemisinin derivatives (AD1-AD8) have been synthesized and evaluated using in vitro models of liver/colon cancer and viral hepatitis B and C. Cell viability assays after treating human cell lines from hepatoblastoma (HepG2), hepatocarcinoma (SK-HEP-1), and colon adenocarcinoma (LS174T) with AD1-AD8 for a short (6h) and long (72h) period revealed that AD5 combined low acute toxicity together with high antiproliferative effect (IC50=1-5μM). Since iron-mediated activation of peroxide bond is involved in artemisinin antimalarial activity, the effect of iron(II)-glycine sulfate …
Molecular analysis on the chemopreventive properties of resveratrol, a plant polyphenol microcomponent.
2002
As a plant microcomponent, resveratrol is a polyphenolic compound produced by several species and found especially in Polygonum roots, peanuts seeds, berries and also grape and therefore can be present in human diet or beverages (red wine, for instance). Traditional chinese medicine and more recent epidemiological studies strongly suggested that resveratrol may act as a cancer chemopreventive compound. The biochemical mechanism by which resveratrol inhibits cell proliferation was provided by studies in numerous human cell lines including our work in hepatoblastoma HepG2 and colorectal tumor SW480 cells. The results show that resveratrol strongly inhibits cell proliferation at the micromolar…