Search results for "colonisation"
showing 10 items of 87 documents
The Monoclonal Antitoxin Antibodies (Actoxumab–Bezlotoxumab) Treatment Facilitates Normalization of the Gut Microbiota of Mice with Clostridium diffi…
2016
Antibiotics have significant and long-lasting impacts on the intestinal microbiota and consequently reduce colonization resistance against Clostridium difficile infection (CDI). Standard therapy using antibiotics is associated with a high rate of disease recurrence, highlighting the need for novel treatment strategies that target toxins, the major virulence factors, rather than the organism itself. Human monoclonal antibodies MK-3415A (actoxumab–bezlotoxumab) to C. difficile toxin A and toxin B, as an emerging non-antibiotic approach, significantly reduced the recurrence of CDI in animal models and human clinical trials. Although the main mechanism of protection is through direct neutraliza…
Chapter 5 : The Beaker Transition in Mediterranean France
2010
In Mediterranean France, the end of the Neolithic is now wellknown. Many cultural groups are chronologically and geographically defined (Rhône-Ouvèze, Fontbouisse, Vérazien...) and the origin of the Beakers phenomenon seems clearly foreign in this context. The existence of this cultural variety in the Final Neolithic leads to: Differences in the first Beaker settlements in these areas, Various types of acculturation, partial or total, of the indigenous groups, with sometimes the survival of certain Late Neolithic traditions, The development of two Middle regional Bell Beakers groups (Pyrenean group and Rhodano-Provençal Group) after the first phenomenon. The beaker pots known on several hun…
Structural and functional changes in the gut microbiota associated to Clostridium difficile infection
2014
Antibiotic therapy is a causative agent of severe disturbances in microbial communities. In healthy individuals, the gut microbiota prevents infection by harmful microorganisms through direct inhibition (releasing antimicrobial compounds), competition, or stimulation of the host’s immune defenses. However, widespread antibiotic use has resulted in short- and long-term shifts in the gut microbiota structure, leading to a loss in colonization resistance in some cases. Consequently, some patients develop Clostridium difficile infection (CDI) after taking an antibiotic (AB) and, at present, this opportunistic pathogen is one of the main causes of antibiotic-associated diarrhea in hospitalized p…
Factors associated with Pneumocystis colonization and circulating genotypes in chronic obstructive pulmonary disease patients with acute exacerbation…
2021
Abstract Pneumocystis jirovecii colonization is frequent during chronic obstructive pulmonary disease (COPD) and patients constitute potential contributors to its interhuman circulation. However, the existence of an environmental reservoir cannot be excluded. We assessed the prevalence and factors associated with Pneumocystis colonization during COPD, and studied circulation between patients and their domestic environment. Pneumocystis molecular detection and mtLSU genotyping were performed in oro-pharyngeal washes (OPW) sampled in 58 patients with COPD acute exacerbation, and in indoor dust, sampled in patients’ homes using electrostatic dust collectors (EDCs). Lung and systemic inflammati…
Survival and growth of transplantedFontinalis dalecarlica (Bryophyta) in controlled flow and short-term regulated flow sites in the Perhonjoki River,…
1999
Impoundment, channelisation and short-term regulation of the Perhonjoki river have caused changes in the distribution and abundance of aquatic mosses. While some moss species have colonised the beds in the channelised and short-term regulated part of the river, Fontinalis spp. are mainly restricted to the sites above the power plant where flow variability is low. Therefore, as a first step towards gaining a better understanding of the factors contributing to the distribution and abundance of Fontinalis dalecarlica (Bruch & Schimp, Fontinalaceae) in the Perhonjoki, a transplant experiment was conducted to test whether short-term flow regulation restricts the survival and growth of this speci…
The Spread of English
2013
English descends from a set of Germanic dialects spoken 4,000 years or so ago in a small area of the far south of Scandinavia. The arrival of Germanic speakers on the island of Britain a millennium and a half ago led to the growth of the language we now call English. This language remained confined to this island for most of its history and, indeed, was not spoken in all parts of the island until extremely recently. During the last five centuries native-speaker English also spread to the Western Hemisphere and then to the Southern Hemisphere, leading to the development of new varieties of the language in the colonised areas, but also to the massive loss of indigenous languages in the Americ…
Invasion history and genetic population structure of riverine macroinvertebrates.
2005
Summary Macroinvertebrate communities of large rivers have experienced dramatic species turnovers in the last decades, which still go on. The analysis of genetic population structure plays a central role in understanding and predicting these biological invasions. Two points of view are considered: the influence of the invasion history on the genetic structuring and the potential implications of genetic structure for future invasibility. Expectations about selectively neutral genetic variation in simple invasion models are compared to case studies of amphipods and Dreissena. The genetic patterns of one amphipod species of the Gammarus fossarum complex yield strong evidence for a stepwise reg…
Besançon at the decolonization time : the decolonization process studied a medium-sized French ciy from 1945 to the 1960s
2016
This doctoral thesis aims at assessing the impact of the decolonisation process on the population of Besançon. The study of an urban community involves taking an interest in various historiographical fields (such as the political and cultural history of both colonisation and decolonisation, as well as the Cold War). From a people's history perspective, our purpose is to grasp how people experienced decolonisation (how they understood, felt, thought, acted). This research covers the period from 1945 up to the 1960s. A two-angled approach has been applied, including comparisons on local and national levels and a thorough investigation of Besançon's social environment in and of itself. The div…
Decolonising European minds through Heritage
2019
By analysing three museums exhibition, this article investigates how the history of European colonialism is approached in an attempt to identify potential for decolonising European minds. The case studies consist of a temporary exhibition (2016–2017) concerning German colonialism at the Deutsches Historisches Museum in Berlin; the permanent exhibition of the House of European History in Brussels and the permanent exhibition of the Sagres Promontory (Portugal), a heritage site related to the conquest of the Americas. The analysis will focus on three aspects: 1) acknowledgement of connections between colonial histories and their contemporary influences in and for Europe; 2) the role of histor…
Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa
2014
The bronchial microbiome in severe COPD during stability and exacerbation in patients chronically colonised by Pseudomonas aeruginosa (PA), has not been defined. Our objective was to determine the characteristics of the bronchial microbiome of severe COPD patients colonised and not colonised by P. aeruginosa and its changes during exacerbation. COPD patients with severe disease and frequent exacerbations were categorised according to chronic colonisation by P. aeruginosa. Sputum samples were obtained in stability and exacerbation, cultured, and analysed by 16S rRNA gene amplification and pyrosequencing. Sixteen patients were included, 5 of them showing chronic colonisation by P. aeruginosa.…