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Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed i…

2010

Heterocyclic aromatic amines (HAAs) can be formed during the cooking of meat and fish at elevated temperatures and are associated with an increased risk for cancer. On the other hand, epidemiological findings suggest that foods rich in fruits and vegetables can protect against cancer. In the present study three teas, two wines, and the juices of 15 fruits and 11 vegetables were investigated for their protective effect against the genotoxic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). To closely mimic the enzymatic activation of these HAAs in humans, genetically engineered V79 Chinese hamster fibroblasts were employed tha…

food.ingredientCytochrome P-450 CYP1A2 InhibitorsHealth Toxicology and Mutagenesismedicine.disease_causeGrapefruit juiceCell LineBeveragesCricetulusfoodCherry juiceHeterocyclic CompoundsCricetinaeVegetablesBotanyGeneticsmedicineAnimalsFood scienceAminescomic_books.seriesOrange juicebiologyChemistryCucumber juicefood and beveragesAntimutagenic Agentsbiology.organism_classificationfood.foodEnzyme assayEnzyme ActivationComet assayFruitRed currantcomic_booksbiology.proteinGenotoxicityMutagensMutation Research/Genetic Toxicology and Environmental Mutagenesis
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