Search results for "commentarie"

Simultaneous Inhibition of Peripheral CB1R and iNOS Mitigates Obesity-Related Dyslipidemia Through Distinct Mechanisms.

2020

Diabetic dyslipidemia, characterized by increased plasma triglycerides and decreased HDL cholesterol levels, is a major factor contributing to nonalcoholic steatohepatitis and cardiovascular risk in type 2 diabetes. Activation of the cannabinoid-1 receptor (CB1R) and activation of inducible nitric oxide synthase (iNOS) are associated with nonalcoholic steatohepatitis progression. Here, we tested whether dual-targeting inhibition of hepatic CB1R and iNOS improves diabetic dyslipidemia in mice with diet-induced obesity (DIO mice). DIO mice were treated for 14 days with (S)-MRI-1867, a peripherally restricted hybrid inhibitor of CB1R and iNOS. (R)-MRI-1867, the CB1R-inactive stereoisomer that …

Extending the Limits of Nature. Political Animals, Artefacts, and Social Institutions

2020

This essay discusses how medieval authors from the thirteenth and fourteenth centuries dealt with a philosophical problem that social institutions pose for the Aristotelian dichotomy between natural and artificial entities. It is argued that marriage, political community, and language provided a particular challenge for the conception that things which are designed by human beings are artefacts. Medieval philosophers based their arguments for the naturalness of social institutions on the anthropological view that human beings are political animals by nature, but this strategy required rethinking the borderline between nature and art. The limits of nature were extended, as social institution…

Clinical effectiveness of influenza vaccination after allogeneic hematopoietic stem cell transplantation: A cross-sectional prospective observational…

2018

Abstract Background Vaccination is the primary method for preventing influenza respiratory virus infection (RVI). Although the influenza vaccine is able to achieve serological responses in some allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, its clinical benefits are still uncertain. Methods In this prospective, cross-sectional study, we retrospectively analyzed the effect of inactivated trivalent influenza vaccination on the prevalence of influenza RVI in a consecutive cohort of 136 allo-HSCT adult recipients who developed 161 RVI over 5 flu seasons (from 2013 to 2018). Respiratory viruses in upper– and/or lower–respiratory tract specimens were tested using multi…

Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

2020

Abstract Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed …

Observaciones sobre una reflexión heterodoxa en los Comentarii de Juan Luis Vives a la Ciudad de Dios de San Agustín

2019

The Patres ecclesiae?s works were a frequent topic of discussion at the time in which many humanists stood against the decadent medieval scholastics. That Juan Luis Vives was part of this tradition is demonstrated in his commentaries on Saint Augustine works. Despite its pedagogical function, the scholia of the Valencian author became quite subjective. In this sense, his ecdotic work or, specially, his «criticisms and censures» can be mentioned. Here, Vives strongly disapproves of the intense political and intellectual turmoil of his epoch. Thus, this article is aimed at describing those annotations in which Vives adopts such an Erasmist point of view to comment Augustine?s De Civitate Dei.…

Challenges in the evolution toward process‐based interventions

2021

Examining the effects of birth order on personality.

2015

This study examined the long-standing question of whether a person’s position among siblings has a lasting impact on that person’s life course. Empirical research on the relation between birth order and intelligence has convincingly documented that performances on psychometric intelligence tests decline slightly from firstborns to laterborns. By contrast, the search for birth-order effects on personality has not yet resulted in conclusive findings. We used data from three large national panels from the United States (N = 5,240), Great Britain (N = 4,489), and Germany (N = 10,457) to resolve this open research question. This data base allowed us to identify even very small effects of birth o…

Ancora sul divieto giustinianeo di commentarii al Digesto

2020

Through some additional arguments, the author confirms his previous interpretation that the Justinian’s ban on commentaries was established only for the Digest and was not specifically addressed to law teachers, but rather concerned the forensic use of the Digest; furthermore, starting from Scheltema’s idea that forbidden commentaries were marginal notes placed directly in the manuscripts, the author hypothesizes that the prohibition aimed at avoiding a writing practice attested in many fields during late Antiquity, i.e. the creation of ‘chaines’ (catenae) of marginalia, which collected different interpretations from other people’s commentaries: such a practice would have contrasted the pro…

Human Immunodeficiency Virus Infection and Diverse Physical Health Outcomes: An Umbrella Review of Meta-analyses of Observational Studies.

2019

Abstract Background Our aim was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies and physical health outcomes associated with human immunodeficiency virus (HIV) but not acquired immunodeficiency syndrome. Methods We performed an umbrella review of observational studies. Evidence was graded as convincing, highly suggestive, suggestive, weak, or nonsignificant. Results From 3413 studies returned, 20 were included, covering 55 health outcomes. Median number of participants was 18 743 (range 403–225 000 000). Overall, 45 (81.8%) of the 55 unique outcomes reported nominally significant summary results (P < .05). O…

Tradeoffs in the evolution of plant farming by ants

2020

Diverse forms of cultivation have evolved across the tree of life. Efficient farming requires that the farmer deciphers and actively promotes conditions that increase crop yield. For plant cultivation, this can include evaluating tradeoffs among light, nutrients, and protection against herbivores. It is not understood if, or how, nonhuman farmers evaluate local conditions to increase payoffs. Here, we address this question using an obligate farming mutualism between the ant Philidris nagasau and epiphytic plants in the genus Squamellaria that are cultivated for their nesting sites and floral rewards. We focused on the ants' active fertilization of their crops and their protection against he…