Search results for "commentary"
showing 10 items of 146 documents
Tissue engineering: how to build a heart
2015
Decellularization and recellularization of hearts from newly dead donors is the latest fashion in cardiac tissue engineering. The first paper came out in 2008 in Nature Medicine (Ott et al., 2008), and news has been recently published in Nature again in July 2013 (Maher, 2013). Brendan Maher in this paper summarizes and comments on the latest important results on decellularization of a human heart and explains the steps that are necessary to build a heart from a decellularized organ. Two sources may be used to obtain a decellularized heart: human and pig heart. Another issue to resolve is the time of decellularization, since the detergents used may also destroy the architecture of the organ…
Response to Kruse-Plass et al. (2017) regarding the risk to non-target lepidopteran larvae exposed to pollen from one or more of three Bt maize event…
2017
We respond to the paper of Kruse-Plass et al. (Environ Sci Eur 29:12, 2017), published in this journal, regarding the risk to non-target lepidopteran larvae exposed to pollen from one or more of three Bt maize events (MON810, Bt11 and 1507). We emphasise that what is important for environmental risk assessment is not the number of pollen grains per se, but the degree of exposure of a NT lepidopteran larva to Bt protein contained in maize pollen. The main text of this response deals with general issues which Kruse-Plass et al. have failed to understand; more detailed refutations of each of their claims are given in Additional file 1. Valid environmental risk assessment requires direct measur…
Presentazione
2013
Il testo propone un articolato commento alle posizioni teoriche e alle linee di ricerca progettuale espresse da Michele Argentino, professore ordinario di Design a Palermo circa la necessità di riconquistare il ruolo sociale alla creatività individuale, riprendendosi il desiderio di diventare nuovamente "Homo Faber". Il testo inoltre presenta gli obiettivi della nuova collana scientifica - diretta dall'autrice - dal Titolo " Design e Contesti": intercettare ambiti di ricerca trasversali alle discipline del progetto, favorire gli intrecci tra idee progettuali e percorsi di innovazione socio-culturale, sviluppare nuove strategie produttive compatibili con i diversi aspetti della sostenibilità.
Note di Abū Naṣr al-Fārābī sulla verità e falsità dell’astrologia
2020
Il presente contributo propone l’introduzione, la traduzione italiana e il commento delle Note sulla verità e falsità dell’astrologia (Nukat fī mā yaṣiḥḥu wa-mā lā yaṣiḥḥu min aḥkām al-nuǧūm) di Abū Naṣr al-Fārābī (m. 950). Tale scritto non è stato trasmesso direttamente dal suo autore né ci è giunto nella sua redazione definitiva, bensì in forma di appunti ricopiati da un grammatico di nome Abū Isḥāq al-Baġdādī. In trenta brevi capitoli al-Fārābī spiega ciò che è accessibile e ciò che è inaccessibile alle predizioni astrologiche e quali aspetti di tale scienza sia opportuno accogliere o respingere.
Does SARS-CoV-2 Trigger Stress-InducedAutoimmunity by Molecular Mimicry? A Hypothesis.
2020
Viruses can generate molecular mimicry phenomena within their hosts. Why shouldsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?Information in this short review suggests that it might be so and, thus, encourages research aimingat testing this possibility. We propose, as a working hypothesis, that the virus induces antibodiesand that some of them crossreact with host’s antigens, thus eliciting autoimmune phenomena withdevasting consequences in various tissues and organs. If confirmed, by in vitro and in vivo tests,this could drive researchers to find effective treatments against the virus.
Conjectures regarding Thalelaios' commentary on the Novus Codex
2014
Il contributo rinviene tracce di un precedente strato del commentario di Taleleo al codex repetitae praelectionis riferibile al Novus Codex Iustinianus. The paper find traces of a previous state of the Thalelaos' commentary on the codex repetitae praelectionis attributable to Novus Codex Justinian.
Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence
2009
Candida albicans , the major human fungal pathogen, undergoes a reversible morphological transition from single yeast cells to pseudohyphal and hyphal filaments (elongated cells attached end-to-end). Because typical C. albicans infections contain a mixture of these morphologies it has, for many years, been difficult to assess the relative contribution of each form to virulence. In addition, the regulatory mechanisms that determine growth in pseudohyphal and hyphal morphologies are largely unknown. To address these questions we have generated a C. albicans strain that can be genetically manipulated to grow completely in the hyphal form under non-filament-inducing conditions in vitro. This w…
Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis.
1999
Neutrophil-borne heparin-binding protein (HBP) is a multifunctional protein involved in the progression of inflammation. HBP is stored in neutrophil granules and released upon stimulation of the cells in proximity to endothelial cells. HBP affects endothelial cells in multiple ways; however, the molecular and cellular mechanisms underlying the interaction of HBP with these cells are unknown. Affinity isolation and enzymatic degradation demonstrated that HBP released from human neutrophils binds to endothelial cell-surface proteoglycans, such as syndecans and glypican. Flow cytometry indicated that a significant fraction of proteoglycan-bound HBP is taken up by the endothelial cells, and we …
Defining gut mycobiota for wild animals: a need for caution in assigning authentic resident fungal taxa
2021
Animal gut mycobiota, the community of fungi that reside within the gastrointestinal tract, make an important contribution to host health. Accordingly, there is an emerging interest to quantify the gut mycobiota of wild animals. However, many studies of wild animal gut mycobiota do not distinguish between the fungi that likely can reside within animal gastrointestinal tracts from the fungal taxa that are non-residents, such as macrofungi, lichens or plant symbionts/pathogens that can be ingested as part of the host’s diet. Confounding the non-resident and resident gut fungi may obscure attempts to identify processes associated with the authentic, resident gut mycobiota per se. To redress th…
Magnaporthe oryzae as an expression host for the production of the unspecific peroxygenase AaeUPO from the basidiomycete Agrocybe aegerita.
2021
Abstract The filamentous fungus Magnaporthe oryzae has the potential to be developed as an alternative platform organism for the heterologous production of industrially important enzymes. M. oryzae is easy to handle, fast‐growing and unlike yeast, posttranslational modifications like N‐glycosylations are similar to the human organism. Here, we established M. oryzae as a host for the expression of the unspecific peroxygenase from the basidiomycete Agrocybe aegerita (AaeUPO). Note, UPOs are attractive biocatalysts for selective oxyfunctionalization of non‐activated carbon‐hydrogen bonds. To improve and simplify the isolation of AaeUPO in M. oryzae, we fused a Magnaporthe signal peptide for pr…