Search results for "comparison"
showing 10 items of 701 documents
Multiplicity- and dependency-adjusted p-values for control of the family-wise error rate
2016
Abstract Under the multiple testing framework, we propose the multiplicity- and dependency-adjustment method (MADAM) which transforms test statistics into adjusted p -values for control of the family-wise error rate. For demonstration, we apply the MADAM to data from a genetic association study.
An effective extension of the applicability of alignment-free biological sequence comparison algorithms with Hadoop
2016
Alignment-free methods are one of the mainstays of biological sequence comparison, i.e., the assessment of how similar two biological sequences are to each other, a fundamental and routine task in computational biology and bioinformatics. They have gained popularity since, even on standard desktop machines, they are faster than methods based on alignments. However, with the advent of Next-Generation Sequencing Technologies, datasets whose size, i.e., number of sequences and their total length, is a challenge to the execution of alignment-free methods on those standard machines are quite common. Here, we propose the first paradigm for the computation of k-mer-based alignment-free methods for…
Reproducibility and concordance of 4 clinically developed programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) assays in triple negative brea…
2019
Abstract Background Atezolizumab (an anti–PD-L1 antibody) has shown clinical activity alone or in combination with nab-paclitaxel in patients (pts) with first-line metastatic TNBC who have PD-L1 expression on their tumour-infiltrating immune cells (IC). We analysed the performance of 4 PD-L1 IHC assays for PD-L1 IC expression in TNBC. Methods Thirty archival TNBC tissue specimens were selected from a set of 107 based on PD-L1 IC expression per VENTANA SP142 ( 5%: 8 cases), to represent the distribution of PD-L1 IC–positivity in the pivotal atezolizumab studies (Emens et al., SABCS 2018; JAMA Oncol 2019). Serial histologic sections were stained with VENTANA SP142 and SP263, and DAKO 22C3 and…
Comparison of conventional descriptive analysis and a citation frequency-based descriptive method for odor profiling: An application to Burgundy Pino…
2010
International audience; The limitations of intensity scoring when describing the odor characteristics of a complex product have been documented in the literature. In the present work, the odor properties of 12 Burgundy Pinot noir wines were described by two independent panels performing, respectively, an intensity-based (conventional descriptive analysis) and a citation frequency-based method. Methods were compared according to three criteria: similarity of the sensory maps, control of panel performance and practical aspects. Intensity scoring and citation frequency data were analyzed, respectively, by Principal Components Analysis (PCA) and Correspondence Analysis (CA) followed by Hierarch…
Do typically and atypically developing children learn and generalize novel names similarly: The role of conceptual distance during learning and at te…
2020
International audience; There is a large body of evidence showing that comparison of multiple stimuli leads to better conceptualization and generalization of novel names than no-comparison settings in typically developing (TD) children. By contrast, the evidence regarding this issue remains scarce in children with intellectual disabilities (ID). Children with intellectual disabilities (ID) and TD children matched on mental age with the Raven's coloured progressive matrices were tested in several novel name learning comparison conditions, with familiar objects. We manipulated the conceptual distance between the learning stimuli in the learning phase and between the learning and generalizatio…
L'efficacité des privatisations françaises : une vision dynamique à travers la théorie de la gouvernance
2004
International audience; A reading of the process of privatization through the corporate governance theory leads to propose a model taking into account, on the one hand, the time dimension of the process of privatization, on the other hand, the contextual, organizational, governance and strategic variables which influence this process. After replicating some traditional tests, we test this model on a sample of French privatized firms and on a seven years horizon. The positive effect traditionally attributed to privatizations is not confirmed. The importance of the effect is subordinated to some of the suggested variables.; Une lecture du processus de privatisation à travers la théorie de la …
Rediscovering the coastal towers of Salerno. History and representation
2023
The focus is on the ongoing developments in the field of digitisation for the preservation and conservation of Cultural Heritage. The work draws attention to the important and necessary multidisciplinary approach, which inextricably links history and new technologies in the field of survey and representation. The case study concerns the defence system of coastal towers in the province of Salerno, an area that has always been rich in history and a crossroads of peoples and civilisations. The use of new technologies in the conservation of historical and architectural heritage is in fact a fundamental step to improve the analysis, conservation and dissemination of these sites and buildings. Af…
Pre-marital and pre-unional financial agreements and their circulation in the context of the new EU regulations 2016/1103 and 2016/1104
2021
Regulations (EU) 2016/1103 and 2016/1104 provide spouses and partners with the possibility to conclude agreements for the organization of their property regime but do not detail their content and structure. Moreover, while the possibility to conclude those agreements even prior to the marriage or the conclusion of a registered partnership is a valuable innovation in comparison with other European Regulations in family matters, some choices made by the European legislator on applicable law will likely be source of inconveniences. Furthermore, as for their recognition and enforcement in the participating Member States ? which will be based on the same rules enacted for decisions, authentic in…
The Relationship Between Goal Orientation, Social Comparison Responses, Self-Efficacy, and Performance
2008
The present study examined whether social comparison responses (identification and contrast in social comparison) mediated the relationship between goal orientation (promotion and prevention) and self-efficacy, and whether self-efficacy was subsequently related with a better performance. As expected, the results showed that promotion-oriented individuals – who are focused on achieving success – had higher self-efficacy than prevention-oriented individuals – who are focused on avoiding failure. Only one of the social comparison responses had a mediating role. That is, the tendency to contrast oneself with others who were doing better mediated the relationship between a prevention goal orien…
Some awkward issues on pairwise comparison matrices
2017
Many decision-making techniques use pairwise comparisons (PCs) elicited by one or more stakeholders involved in a given corresponding decision-making process. In very complex problems, the number of criteria or options to be compared may be too large, thus limiting PC applicability to large-scale decision problems due to the so-called curse of dimensionality, that is, a large number of pairwise comparisons need to be produced from a decision maker. For example, in AHP, Saaty [1] recommends that to obtain a reasonable and consistent PC matrix, the number of comparing elements should be at most seven. In [2] and [3], arguing on limitations of the human capabilities, the maximum number of elem…