Search results for "competing risk"

Liver and cardiovascular mortality after hepatitis C virus eradication by DAA: Data from RESIST-HCV cohort

2021

Real-world evidence on the course of Hepatitis C Virus (HCV) chronic liver disease after Sustained Virologic Response (SVR) obtained with direct-acting antiviral drugs (DAAs) are still limited, and the effects on mortality remain unclear. We evaluated the post-treatment survival of 4307 patients in the RESIST-HCV cohort (mean age 66.3 ± 11.6 years, 56.9% males, 24.7% chronic hepatitis, 66.9% Child-Pugh A cirrhosis and 8.4% Child-Pugh B cirrhosis) treated with DAAs between March 2015 and December 2016 and followed for a median of 73 weeks (range 16–152). Proportional cause-specific hazard regression for competing risks was used to evaluate the survival and to assess the predictors of liver a…

Risk factors of de novo malignancies after liver transplantation: a French national study on 11004 adult patients.

2021

International audience; Background: After liver transplantation (LT),de novo malignancies are one of the leading causes of late mortality. The aim of the present retrospective study was to identify the risk factors of de novo malignancies in a large cohort of LT recipients in France, using Fine and Gray competing risks regression analysis.Methods: The study population consisted in 11004 adults transplanted between 2000 and 2013, who had no history of pre-transplant malignancy, except primary liver tumor. A Cox model adapted to the identification of prognostic factors (competitive risks) was used.Results: From the entire cohort, one (or more)de novo malignancy was reported in 1480 L T recipi…

Predicting survival in node-positive prostate cancer after open, laparoscopic or robotic radical prostatectomy: A competing risk analysis of a multi-…

2016

Objectives: To investigate cancer-specific mortality and other-cause mortality in prostate cancer patients with nodal metastases. Methods: The study included 411 patients treated with radical prostatectomy and pelvic lymph node dissection for prostate cancer with lymph node metastases at 10 tertiary care centers between 1995 and 2014. Kaplan–Meier analyses were used to assess cancer-specific mortality-free survival rates at 8 years' follow up in the overall population, and after stratifying patients according to clinical and pathological parameters. Uni- and multivariable competing risk Cox regression analyses were used to assess cancer-specific mortality and other-cause mortality. Finally,…

Mortality in early-stage, surgically resected non-small cell lung cancer less than 3cm of size: Competing risk analysis

2015

Abstract Background and objective Survival studies of non-small cell lung cancer (NSCLC) are usually based on the Kaplan–Meier method. However, other factors not covered by this method may modify the observation of the event of interest. There are models of cumulative incidence (CI), that take into account these competing risks, enabling more accurate survival estimates and evaluation of the risk of death from other causes. We aimed to evaluate these models in resected early-stage NSCLC patients. Patients and method This study included 263 patients with resected NSCLC whose diameter was ≤3 cm without node involvement (N0). Demographic, clinical, morphopathological and surgical variables, TN…

Advances in survival analysis: applications and extensions of the "standard" competing risks model

2023

Bayesian joint modeling of bivariate longitudinal and competing risks data: An application to study patient-ventilator asynchronies in critical care …

2017

Mechanical ventilation is a common procedure of life support in intensive care. Patient-ventilator asynchronies (PVAs) occur when the timing of the ventilator cycle is not simultaneous with the timing of the patient respiratory cycle. The association between severity markers and the events death or alive discharge has been acknowledged before, however, little is known about the addition of PVAs data to the analyses. We used an index of asynchronies (AI) to measure PVAs and the SOFA (sequential organ failure assessment) score to assess overall severity. To investigate the added value of including the AI, we propose a Bayesian joint model of bivariate longitudinal and competing risks data. Th…

Elastīgais parametriskais modelis izdzīvošanas datiem ar konkurējošiem riskiem

2015

Konkurējošie riski ir izplatīta parādība izdzīvošanas analīzē. Tie rodas, kad subjekts atrodas vairāku savstarpēji izslēdzošu notikumu riska zonā. Populārākā metode, pētot šāda veida datus, ir Deivida Koksa semi-parametriskā modeļa izmantošana. Darbā ir aplūkots alternatīvais variants izdzīvošanas datiem ar konkurējošiem riskiem – elastīgais parametriskais modelis, kas sniedz gludus novērtējumus galvenajiem raksturlielumiem – konkrēto cēloņu riskam un kumulatīvo biežumu funkcijai. Turklāt, izmantojot šo modeli, ir viegli iekļaut no laika atkarīgus ietekmējošos mainīgos. Darbā tiek aprakstīta konkurējošo risku elastīgā parametriskā modeļa būtība, un metode ir salīdzināta ar Koksa modeli. Ir …

Repeated kidney re-transplantation—the Eurotransplant experience: a retrospective multicenter outcome analysis

2020

Transplant international (2020). doi:10.1111/tri.13569

From South to North? Mobility of Southern Italian Students at the Transition from the First to the Second Level University Degree

2018

In the last decades, the Italian University System has encountered several structural reforms aimed at making it more internationally competitive. Among them, the introduction of the University financial autonomy has triggered an “internal” competition among Universities to attract students from the entire country. Students’ enrollment at the first level has decreased significantly especially after the economic crisis of 2008, while the students’ migration from the South to the Central and Northern regions of the country has increased. These phenomena have created further inequalities within the country and a cultural and socio-economic loss for the South that does not appear to slow down. …