Search results for "complement"

X-ray Crystal Structure of Woodinine and Conformational Analysis by Semiempirical and 1H-NMR Methods

1997

The mol. structure of (-)-woodinine (I), a carboline-based alkaloid with antibacterial and antimycobacterial activities, was investigated by X-ray crystallog., NMR, and semiempirical quantum chem. methods. The X-ray crystal structure of I showed the indole ring in the expected planar conformation, the pyrrolidine ring in an envelope conformation, and a weak intramol. hydrogen bond between the pyrrolidine nitrogen and the proton of the indole nitrogen. NMR expts. indicated that this hydrogen bond is not present in soln. and that further differences exist between the crystal and the soln. structures of I. By semiempirical quantum chem. methods, different local energy min. conformations of I, …

Metabolites from the Aerial Parts of the Sicilian Population of Artemisia alba

2013

Phytochemical investigation of the CH2Cl2 extract of the aerial parts of Artemisia alba Turra afforded one new irregular sesquiterpenoid, artemiric acid, and five known metabolites: hydroxydavanone, the coumarins isofraxidin and scopoletin, (6 S*,7 S*,10 R*)–6,10-dimethyl-7,10-epoxyocta-11-enoic acid and artalbic acid. From the MeOH extract three flavonoids were identified: chrysoeriol, quercetin and isorhamnetin. The possible biogenetic pathways of artemiric and artalbic acids are discussed.

Chemical composition of the essential oils of Centaurea sicana and C. giardinae growing wild in Sicily

2008

The essential oils of Centaurea sicana (S) and C. giardinae (G) were studied by GC and GC-MS. Thirty constituents for S, representing 81.5% of the total oil, and 24 compounds for G (94.2% of the total) were identified. The oils were rich in sesquiterpenoids (47.9% for S and 54.7% for G) and hydrocarbons (25.9% for S and 31.7% for G). Germacrene D (13.3%), ( E)-β-farnesene (8.3%), nonacosane (7.3%), heptacosane (6.5%) and phytol (6%) were recognized as the main constituents for S, while caryophyllene oxide (17.7%), nonacosane (14.5%), germacrene D (11.5%), caryophyllene (11.2%) and heptacosane (10.3%) were the main compounds for G.

Current drugs in early development for hereditary angioedema: potential for effective treatment

2014

Hereditary angioedema (HAE) through C1 inhibitor deficiency is a rare but important disease. It is characterized by recurrent episodes of angioedema, which commonly affects the skin (in the form of swelling in the extremities, face and genitals) as well as the gastrointestinal tract (abdominal pain attacks). In approximately 1% of cases of angiodema-related swelling, there is obstruction of the upper airway, which is potentially life-threatening. Therefore, HAE due to C1 inhibitor deficiency may be associated with significant morbidity and mortality. Recent research has added to our ever-increasing understanding of the pathogenesis of HAE, which has, in addition, new clinical trials with ne…

Effects of hydrocortisone on binding of IgG or C3b-coated erythrocytes to human monocytes and polymorphonuclear leucocytes.

1979

Reduction of myocardial infarct size with sCR1sLex, an alternatively glycosylated form of human soluble complement receptor type 1 (sCR1), possessing…

1999

1 This study investigated the effects of soluble complement receptor type 1 (sCR1) or sCR1sLex, agents which function as a complement inhibitor or as a combined complement inhibitor and selectin adhesion molecule antagonist, respectively, on the infarct size and cardiac troponin T (cTnT) release caused by regional myocardial ischaemia and reperfusion in the rat. 2 Eighty-two, male Wistar rats were subjected to 30 min occlusion of the left anterior descending coronary artery (LAD) followed by 2 h of reperfusion. Haemodynamic parameters were continuously recorded and at the end of the experiments infarct size (with p-nitro-blue tetrazolium) and cTnT release were determined. 3 Infusion of sCR1…

Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants.

2001

In search of functions involved in the regulation of gene amplification, and given the relevance of chromosome breakage in initiating the process, we analyzed the gene amplification ability of cells hypersensitive to inducers of DNA double-strand breaks and defective in cell cycle control: two human fibroblast strains derived from patients affected by ataxia telangiectasia (AT) and two hamster mutant cell lines belonging to complementation group XRCC8 of the rodent X-ray-sensitive mutants. These mutants are considered hamster models of AT cells. To measure gene amplification, the frequency and the rate of occurrence of N-(phosphonacetyl)-L-aspartate resistant cells were determined. In both …

Complement and Atherogenesis

1999

Abstract —Complement activation occurs in temporal correlation with the subendothelial deposition of LDL during early atherogenesis, and complement also plays a pathogenetic role in promoting lesion progression. Two lesion components have been identified that may be responsible for complement activation. First, enzymatic degradation of LDL generates a derivative that can spontaneously activate complement, and enzymatically degraded LDL (E-LDL) has been detected in the lesions. Second, C-reactive protein (CRP) colocalizes with complement C5b-9, as evidenced by immunohistological studies of early atherosclerotic lesions, so the possibility exists that this acute phase protein also fulfills a…

The grammaticalization and pragmaticalization of cleft constructions in Present-Day English

2012

The present paper examines the development of the variation between a marked and an unmarked infinitival complement clause in three types of cleft constructions in 20th century English. Data from corpora of written and spoken British (BrE) and American English (AmE) evidence a significantly divergent development of these clefts types in speaking when compared to writing. The written corpora show a steady increase in the frequency of clefts, and a decrease of the to-infinitive paired with an increase of the bare infinitive, thus a reversal of preferences in both varieties in all three types of clefts. This erosion of to as an (optional) grammatical marker leads to a higher degree of syntacti…

Probing intruder structures in lead nuclei

2003

In-beam γ-ray spectroscopy measurements provide important information on coexisting normal and intruder configurations in lead nuclei. However, in these experiments the yrast states are preferentially populated so that in many cases nothing is known about non-yrast states that are essential for obtaining a fuller understanding. Complementary experiments designed to study fine structure in the a decays of polonium nuclei have led to the discovery of low-spin non-yrast states in the daughter lead nuclei, while higher-spin states can be identified through the γ decays of isomeric states. The α-decay studies have the additional benefit of allowing information on configuration mixing in the polo…