Search results for "complement"
showing 10 items of 2113 documents
Immunoaffinity purification and characterization of mitochondrial membrane-bound D-3-hydroxybutyrate dehydrogenase from Jaculus orientalis.
2008
Abstract Background The interconversion of two important energy metabolites, 3-hydroxybutyrate and acetoacetate (the major ketone bodies), is catalyzed by D-3-hydroxybutyrate dehydrogenase (BDH1: EC 1.1.1.30), a NAD+-dependent enzyme. The eukaryotic enzyme is bound to the mitochondrial inner membrane and harbors a unique lecithin-dependent activity. Here, we report an advanced purification method of the mammalian BDH applied to the liver enzyme from jerboa (Jaculus orientalis), a hibernating rodent adapted to extreme diet and environmental conditions. Results Purifying BDH from jerboa liver overcomes its low specific activity in mitochondria for further biochemical characterization of the e…
Sustainability in the restoration and management of the historic architecture in Palermo
2015
This research investigates the energy and environmental sustainability in the restoration and conservation of historic buildings. It focuses on the architectural heritage of Palermo, which can be a significant case study for the Mediterranean area. Its objective is to analyse the current energy performance of this historic architecture and its potential for energy improvement. Therefore, it aims at proposing a methodology to combine the enhancement of energy and environmental performances of the historic architecture of Palermo with the need of its material and aesthetic conservation, in the frame of the current regulations.
Rebuilt the space using stone or brick vaulted systems: catching the contemporary challenge of construction tradition
2019
In the recovery and restoration sites, as well as in the versatile word of university research about construction history, its not infrequent to study stereotomy for the re-proposal of stony or tiled vaulted systems, sometimes complex for their constitutive geometry, equipment, preliminary/subsidiary carpentry works. It represents a didactic study-key also in Engineering and Architecture Schools, through laboratories that teach to future designers a know-how that can be easily spent in their professional repercussions.
Innovative, Translucent and Multi-functional Components for the Building Envelope: technological and performance optimization
2017
The paper describes the actions aimed at the technology and performance optimization of an innovative, multi-functional building component made of precast and pre-stressed glass blocks useful for the construction of sustainable building envelopes able to reduce the energy consumption and to produce clean energy from the sun. The design optimization of different sub-components and the choice of the right materials for guaranteeing their good response in terms of mechanical resistance, thermal and acoustic insulation, light transmission, electricity production, integration with other components, dimensional coordination, are particularly described.
Architecture in iron in the city of XIX century Roof structures of theatres and covered markets in Palermo
2016
In post-unification Palermo, components manufactured abroad were usually used for complementary iron structures (greenhouses and skylights, projecting roofs, staircases…), whereas, for more demanding works, more weight was given to the contribution of producers with experience gained in the field of metal construction. Analysis is here carried out on the works of greatest importance, from the roofs of the two major theatres to the roofing of food market structures; the finest technicians were employed and a critical debate was triggered in the city with regard to formal, static and building aspects.
Strategies, Technologies and Novel Components for the Architectural Integration of Photovoltaics
2015
La ricerca riguarda l'integrazione architettonica del fotovoltaico (FV) per il retrofit energetico del patrimonio edilizio esistente e la costruzione di edifici a energia zero (ZEB). L'obiettivo è lo studio e la successiva definizione di strategie, tecnologie e componenti innovativi per l'involucro edilizio che integrino il fotovoltaico, con particolare attenzione verso le tecnologie fotovoltaiche di nuova generazione. Il lavoro si concentra anche sull'ottimizzazione energetica e sull'analisi delle prestazioni di un componente innovativo per il BIPV (Building Integrated Photovoltaics, letteralmente fotovoltaico integrato negli edifici) utile alla costruzione di involucri edilizi sostenibili…
The assessment of the reliability of an innovative 3rd generation solar cell integrated with “thermal belt” glass block
2017
Glass block is a building product widely used for the construction of translucent building façades and roofs. The need to adapt the product to the regulations in the field of energy saving and environmental sustainability has led to the design of innovative configurations, through the integration of different sub-components. These ones are able to improve its energy performance by means of the integration of a“thermal belt”, cold glued to the glass shells, which constitute the traditional glass block, and 3rd generation solar cells. This paper reports the first results of the experimental program designed to assess some durability components: inherent and critical reliability. <div id="g…
Yoga en España. Proceso de regulación profesional
2015
New approaches to spirituality go hand in hand with emerging physical, psychological and spiritual movements that have had a clear impact on many areas, and in particular on health and well-being. It is increasingly common to find nurses teaching yoga or doctors prescribing mindfulness. Use of socalled Complementary and Alternative Medicine (CAM) is becoming mainstream. Health centres, medical practices and even schools are offering a growing number of alternative therapies, resulting in the need for effective legal regulation of these activities, both in terms of professional recognition and training. In Spain, recent legislation represents a significant breakthrough in the regulation of y…
Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth
2017
C1q is the first recognition subcomponent of the complement classical pathway, which acts towards the clearance of pathogens and apoptotic cells. C1q is also known to modulate a range of functions of immune and non-immune cells, including their involvement in placental development and sensorial synaptic pruning. We have recently shown that C1q can promote tumour by encouraging their adhesion, migration and proliferation in addition to angiogenesis and metastasis. In this study, we have examined the role of C1q in the microenvironment of malignant pleuric mesothelioma (MPM), a rare form of cancer commonly associated with exposure to asbestos. We found that C1q was highly expressed in all MPM…
Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications
2018
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriages. However, the exact mechanisms involved in the clinical manifestations of the syndrome are still a matter of investigation. In particular, while vascular thrombosis is apparently not associated with inflammation, the pathogenesis of miscarriages can be explained only in part by the aPL-mediated hypercoagulable state and additional non-thrombotic effects, including placental inflammation, have b…