Search results for "complement"
showing 10 items of 2113 documents
Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent manner. Being a pattern recognition molecule of the innate immunity, C1q can recognize a number of self, non-self and altered-self ligands and bring about effector mechanisms designed to clear pathogens via opsonisation and inflammatory response. C1q is locally synthesized by macrophages and dendritic cells, and thus, can get involved in a range of biological processes, such as angiogenesis and tissue remodeling, immune modulation, and immu…
CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis
2019
Abstract Background and Aims: In immunosuppressed individuals Aspergillus (A.) fumigatus is a frequent cause of invasive pulmonary aspergillosis (IPA) which is highly associated with relevant morbidity and mortality. Moreover, it often occurs in patients suffering from leukocyte-adhesion deficiency type 1 (LAD1) which is triggered by a functional loss of CD18 in ß2 integrin receptors as these receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit. ß2 integrin receptors are differentially expressed by leukocytes, and are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Here, we asked …
Artemisinin–Second Career as Anticancer Drug?
2015
Artemisinin represents a showcase example not only for the activity of medicinal herbs deriving from traditional chinese medicine, but for phytotherapy in general. Its isolation from Sweet Wormwood (qinhao, Artemisia annua L.) represents the starting point for an unprecedent success story in the treatment of malaria worldwide. Beyond the therapeutic value against Plasmodium parasites, it turned out in recent years that the bioactivity of artemisinin is not restricted to malaria. We and others found that this sesquiterpenoid also exerts profound anticancer activity in vitro and in vivo. Artemisinin-type drugs exert multi-factorial cellular and molecular actions in cancer cells. Ferrous iron …
Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine Clq
1989
AbstractcDNA clones coding for the B-chain of murine Clq were isolated from a mouse macrophage library. The characterized clones include the total coding region plus a leader sequence. High homology was found with human Clq B-chain in the coding region (81%). Northern blot analysis of total RNA from different tissues of Balb/c mice showed one band of approximately 1.2 kb. The highest signal was found in RNA preparations of thioglycolate-activated peritoneal macrophages. The probe also hybridized with mRNA from spleen, thymus and heart. Extremely weak signals were found in liver, kidney, lung and intestine tissues.
Trade-offs or Complements? : Balancing Diversified Stakeholder Expectations, Institutional Pressures, and Functional Demands in the Strategic Managem…
2019
While scholars and practitioners have warned that business schools are losing their edge in creating and disseminating relevant knowledge in the crosscurrent of environmental demands, the management and organization of higher education institutions (HEIs) have been described as “herding cats” and “organized anarchy”. The teaching–research nexus forms the cornerstone of academic organization and has a quintessential role in strategic management. However, despite the growing body of literature on HEIs’ teaching–research nexus, organization, and environmental changes, few studies have examined the interplay of the three. Therefore, this study combines two contingency-theory views to examine th…
Exploring the use of Vibroacoustic treatment for managing chronic pain and comorbid mood disorders : A mixed methods study
2019
Introduction: Chronic pain is a worldwide issue with common comorbidities of depression and anxiety, altogether inhibiting one’s personal relationships and capability to work. Music has long been used as a means to improve pain and mood, and the tactile application of music has shown promising and beneficial results for the treatment of both psychological and physical symptoms. VA treatment uses low frequency sinusoidal sound vibration (20-120Hz) supported by client-preferred music listening and therapeutic interaction. Methods: Using mixed methods, this study addresses the addition of a self-care VA intervention to maintain the effects of practitioner-led VA treatments and to increase pati…
Self-Complementary Dimers of Oxalamide-Functionalized Resorcinarene Tetrabenzoxazines
2018
Self‐complementarity is a useful concept in supramolecular chemistry, molecular biology and polymeric systems. Two resorcinarene tetrabenzoxazines decorated with four oxalamide groups were synthesized and characterized. The oxalamide groups possessed self‐complementary hydrogen bonding sites between the carbonyls and amide groups. The self‐complementary nature of the oxalamide groups resulted in self‐included dimeric assemblies. The hydrogen bonding interactions within the tetrabenzoxazines gave rise to the formation of dimers, which were confirmed by single‐crystal X‐ray diffractions analysis and supported by NMR spectroscopy and mass spectrometry. The self‐included dimers were connected b…
Learning research in a laboratory classroom : a reflection on complementarity and commensurability among multiple analytical accounts
2022
With the myriad theories generated through research over the years, a continuing challenge for researchers is to navigate the multitude of theories in order to communicate their research, integrate empirical results, and make progress as a field by building upon empirical research. The Social Unit of Learning project was purposefully designed so that researchers from multiple disciplines with different theoretical perspectives could work together to examine the complexity of the mathematics classroom. In this paper, we reflect on the multiple analytical accounts generated from the project, drawing from the notions of complementarity and commensurability. Two parallel analyses, applying the …
"Mirrors"
2021
[no abstract]
Networks of Music and Images
2017
Il potere di astrazione della teoria delle categorie può essere utilizzato per descrivere procedure e strutture musicali. La stessa teoria matematica può essere applicata alle forme visuali e alle loro trasformazioni, comprese le applicazioni computazionali. Poiché è possibile associare musica e immagini attraverso apposite mappature (mappings), è anche possibile connettere reti (networks) di frammenti musicali e di immagini descrivendo progressivamente le modifiche apportate alle forme musicali e visuali. In questo articolo si intende proporre un nuovo approccio alla scrittura musicale secondo questi principi, ovvero componendo musica a partire da una rete di immagini in grado di “sonorizz…