Search results for "complementary and alternative medicine"

showing 10 items of 632 documents

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

2019

Abstract Background Cucurbitacin E (CuE) is an oxygenated tetracyclic triterpenoid isolated from the fruits of Citrullus colocynthis (L.) Schrad. Purpose This study outlines CuE's cytotoxic activity against drug-resistant tumor cell lines. Three members of ABC transporters superfamily, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and ABCB5 were investigated, whose overexpression in tumors is tightly linked to multidrug resistance. Further factors of drug resistance studied were the tumor suppressor TP53 and the epidermal growth factor receptor (EGFR). Methods Cytotoxicity assays (resazurin assays) were used to investigate the activity of Citrullus colocynthis and CuE towar…

Abcg2Drug ResistancePharmaceutical ScienceATP-binding cassette transporterMicroarraySubfamily Gchemistry.chemical_compoundGene Knockout Techniques0302 clinical medicineEpidermal growth factorPhytogenicDrug DiscoveryATP Binding Cassette Transporter Subfamily G Member 2Cancer0303 health sciencesTumorLeukemiabiologyChemistryABCB5TransfectionCell cycleNeoplasm ProteinsGene Expression Regulation NeoplasticErbB ReceptorsMolecular Docking SimulationSubfamily B030220 oncology & carcinogenesisMolecular MedicineCitrullus colocynthiMember 2Member 1ATP Binding Cassette Transporter Subfamily BATP Binding Cassette TransporterAntineoplastic AgentsCell Line03 medical and health sciencesCell Line TumorHumansATP Binding Cassette Transporter Subfamily B Member 1030304 developmental biologyCucurbitacin EPharmacologyNeoplasticTraditional herbal medicineCancer; Citrullus colocynthis; Drug resistance; Microarray; Traditional herbal medicine; ATP Binding Cassette Transporter Subfamily B; ATP Binding Cassette Transporter Subfamily B Member 1; ATP Binding Cassette Transporter Subfamily G Member 2; Antineoplastic Agents Phytogenic; Cell Line Tumor; Citrullus colocynthis; Doxorubicin; Drug Resistance Neoplasm; ErbB Receptors; Gene Expression Regulation Neoplastic; Gene Knockout Techniques; Humans; Leukemia; Molecular Docking Simulation; Neoplasm Proteins; Triterpenes; Tumor Suppressor Protein p53Antineoplastic Agents PhytogenicTriterpenesComplementary and alternative medicineGene Expression RegulationDrug Resistance NeoplasmDoxorubicinCancer cellbiology.proteinCancer researchNeoplasmCitrullus colocynthisTumor Suppressor Protein p53
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Agrobacterium tumefaciens-mediated genetic transformation of the cardenolide-producing plant Digitalis minor L.

2003

A repeatable transformation system has been established for Digitalis minor using Agrobacterium tumefaciens. Leaf explants from 30-day-old seedlings were inoculated with either EHA105 (carrying the nptII and gusA genes) or AGL1 (with the bar and gusA genes) strains. Among the tested factors influencing T-DNA transfer to plants, the EHA105 strain and the addition of acetosyringone to the co-culture medium increased transformation. The highest transformation efficiency (8.4%) was obtained when freshly isolated explants, soaked in a bacterial suspension with an OD 550 of 0.9, were subcultured on selection medium after a 4-day co-culture with the bacteria. Evidence of stable transgene integrati…

AcetosyringoneAgrobacteriumPharmaceutical ScienceGenetically modified cropsBiologyAnalytical Chemistrychemistry.chemical_compoundTransformation GeneticDrug DiscoveryBotanyCardenolideHumansPharmacologyDigitalisfungiOrganic Chemistryfood and beveragesAgrobacterium tumefaciensbiology.organism_classificationPlants Genetically ModifiedPlant LeavesTransformation (genetics)Complementary and alternative medicinechemistryAgrobacterium tumefaciensMolecular MedicineTransformation efficiencyExplant culturePlanta medica
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Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation

2020

The prevalence of nosocomial infections due to multidrug resistant (MDR) bacterial strains is associated with high morbidity and mortality. Folk medicine and ethnopharmacological data can provide a broad range of plants with promising antimicrobial activity. Triphala, an Ayurvedic formula composed of three different plants: Terminalia chebula Retz., Terminalia bellirica (Gaertn.) Roxb. (Combretaceae), and Phyllanthus emblica L. (Phyllanthaceae), is used widely for various microbial infections. Various extraction techniques were applied in the extraction of the biologically active constituents of Triphala in order to compare their efficiency. Microwave-assisted extraction (MAE) was shown to …

Active ingredient0303 health sciencesTraditional medicineArticle SubjectCetyl alcoholAntimicrobial01 natural sciencesDosage form0104 chemical sciencesTerminalia chebulaOther systems of medicine010404 medicinal & biomolecular chemistry03 medical and health scienceschemistry.chemical_compoundIngredientComplementary and alternative medicinechemistryCarvacrolTriphalaRZ201-999Research Article030304 developmental biologyEvidence-Based Complementary and Alternative Medicine
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Postural equilibrium: functional system and its stabilization by means of osteoreflexotherapy.

1998

Our investigations have confirmed that the osteoreceptive sensory system participates in the polysensoric regulation of animal and human posture. Experiments with animals have demonstrated that the irritation of osteoreceptors by electric pulses leads to osteoreceptive response potentials of the same parts of the brain (Deiter's nuclei, cerebellum, caudate nucleus, cortical motor centre etc.) which participate in the regulation of animal and human posture and other motion acts. Close functional relations have been established between the skin, bone, vestibular and muscle sensory systems in the brain structures where the osteoreceptive excitation converges. The studies of osteoreceptive sens…

AdultCerebellummedicine.medical_specialtyAdolescentPostureCaudate nucleusSensory systemmedicine.disease_causemedicinePostural BalanceHumansPostural BalanceAgedVestibular systemAged 80 and overbusiness.industryGeneral NeuroscienceMiddle AgedFunctional systemSurgeryAnesthesiology and Pain Medicinemedicine.anatomical_structureComplementary and alternative medicineCalcaneusIrritationbusinessNeuroscienceReflexotherapyAcupunctureelectro-therapeutics research
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Identifying profiles of complementary and alternative medicine believers and/or users

2020

The present study focuses on the identification of profiles of CAM believers and/or users. Using data from the Spanish CIS Barometer (2018) and a sample of 2486 Spaniards, a hierarchical and non-hierarchical cluster analysis and discriminant analysis have been performed. Profiles of people with a high level of belief in CAM and/or CAM users were identified. Results reflect relationships between personal factors (healthy lifestyle and status, political and religious ideology) and satisfaction with conventional medicine with the belief/use of CAM. Personal factors and satisfaction are not related to the level of belief in CAM. We have tried to fulfil some gaps detected in the literature: much…

AdultComplementary TherapiesMaleConventional medicinemedicine.medical_specialtymedia_common.quotation_subjectAlternative medicineSample (statistics)03 medical and health sciencesPolitics0302 clinical medicineSurveys and QuestionnairesmedicineHumans030212 general & internal medicinemedia_commonbusiness.industryMiddle AgedIdentification (information)Complementary and alternative medicinePatient SatisfactionSpainFemaleIdeologyPatient ParticipationbusinessAttitude to HealthSocial psychology030217 neurology & neurosurgeryComplementary Therapies in Clinical Practice
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Experiences with the use of complementary and alternative medicine in nursing homes: A focus group study.

2016

Abstract Introduction The use of complementary and alternative medicine is increasing outside the Norwegian public health service. The purpose of this study was to gain insight into the experiences of nurses and auxiliary nurses with the use of CAM in care for nursing home residents. Method Focus group interviews with a total of thirteen nurses and auxiliary nurses from three nursing homes were conducted. Data were analyzed using systematic text condensation. Results Participants had experiences from aromatherapy, plant medicine, music therapy and pet therapy. They experienced the use of CAM as effective, exciting and rewarding, but also challenging and dependent on supportive leaders. CAM …

AdultComplementary Therapiesmedicine.medical_specialtyMusic therapyAttitude of Health PersonnelAlternative medicineNursesNorwegian03 medical and health sciences0302 clinical medicineNursingmedicineHumans030212 general & internal medicineNurse educationCompetence (human resources)business.industryNorwayFocus GroupsMiddle AgedFocus grouplanguage.human_language030205 complementary & alternative medicineNursing HomesComplementary and alternative medicinelanguagebusinessNursing homesAromatherapyComplementary therapies in clinical practice
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Attitudes About Hypnosis: Factor Analyzing the VSABTH-C With an American Sample

2012

In the present study, the authors factor-analyzed responses from 1,141 American undergraduate students to the Valencia Scale of Attitudes and Beliefs Toward Hypnosis-Client Version. They obtained an 8-factor solution accounting for 66% of the total variance in responses. A confirmatory factor analysis indicated acceptable fit of their model and those reported earlier by Carvalho et al. (2007) and Capafons, Mendoza, et al. (2008) using Portuguese and international samples, respectively. Unlike previous factor analyses of the scale, the authors obtained an independent clusters solution. Distinctions between the authors' model and those reported previously are discussed.

AdultCross-Cultural ComparisonHypnosisValidation studyAdolescentPsychometricsScale (ratio)CultureSample (statistics)Factor (chord)Young AdultSurveys and QuestionnairesHumansStudentsReproducibility of ResultsGeneral MedicineCross-cultural studiesUnited Stateslanguage.human_languageConfirmatory factor analysisComplementary and alternative medicinelanguagePortuguesePsychologyAttitude to HealthSocial psychologyHypnosisClinical psychologyAmerican Journal of Clinical Hypnosis
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Interrelationships between dental occlusion and plantar arch

2011

The aim of this study was to evaluate the influence of different jaw relationships on the plantar arch during gait.168 subjects, participating in this study, were distributed into two groups: a control (32 males and 52 females, ranging from 18 to 36 years of age) and a Temporomandibular joint disorders group (28 males and 56 females, ranging from 19 to 42 years of age). Five baropodometric variables were evaluated using a baropodometric platform: the mean load pressure on the plantar surface, the total surface of feet, forefoot vs rearfoot loading, forefoot vs rearfoot surface, and the percentage of body weight on each limb. The tests were performed in three dental occlusion conditions: man…

AdultMaleComplementary and Manual TherapyAdolescentDentistryPhysical Therapy Sports Therapy and RehabilitationYoung AdultStatistical significancemedicine.arterymedicineHumansGaitFootbusiness.industryDental occlusionForefootRehabilitationRepeated measures designTemporomandibular Joint DisordersGaitBiomechanical PhenomenaTemporomandibular jointbody regionsStomatognathic systemmedicine.anatomical_structureComplementary and alternative medicinePlantar archFemalebusinessJournal of Bodywork and Movement Therapies
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Treatment of tension-type headache with articulatory and suboccipital soft tissue therapy: A double-blind, randomized, placebo-controlled clinical tr…

2013

This study researches the effectiveness of two manual therapy treatments focused on the suboccipital region for tension-type headache. A randomized double-blind clinical trial was conducted over a period of four weeks with a follow-up at one month. Eighty-four patients with a mean age of 39.7 years (SD 11.4) with tension-type headache were assigned to 4 groups which included the following manual therapy treatment: suboccipital soft tissue inhibition; occiput-atlas-axis global manipulation; combination of both techniques; and a control group. The primary assessment consisted of collecting socio-demographic data and headache characteristics in a one-month base period, data such as age, gender…

AdultMaleComplementary and Manual TherapySoft tissue therapymedicine.medical_specialtyAdolescentPhysical Therapy Sports Therapy and RehabilitationPlaceboDouble blindYoung AdultSex FactorsDouble-Blind MethodmedicineHumansPain ManagementTherapy Soft TissueAgedbusiness.industryTension-Type HeadacheRehabilitationAge FactorsPatient AcuitySoft tissueMiddle AgedMusculoskeletal ManipulationsSurgeryIntensity (physics)Clinical trialComplementary and alternative medicineFemaleHeadachesmedicine.symptomManual therapybusinessJournal of Bodywork and Movement Therapies
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Osteopathic manual therapy versus conventional conservative therapy in the treatment of temporomandibular disorders: A randomized controlled trial

2010

Summary Objective Temporomandibular disorders (TMD) is a term reflecting chronic, painful, craniofacial conditions usually of unclear etiology with impaired jaw function. The effect of osteopathic manual therapy (OMT) in patients with TMD is largely unknown, and its use in such patients is controversial. Nevertheless, empiric evidence suggests that OMT might be effective in alleviating symptoms. A randomized controlled clinical trial of efficacy was performed to test this hypothesis. Methods We performed a randomized, controlled trial that involved adult patients who had TMD. Patients were randomly divided into two groups: an OMT group (25 patients, 12 males and 13 females, age 40.6±11.03) …

AdultMaleComplementary and Manual Therapymedicine.medical_specialtyPhysical Therapy Sports Therapy and Rehabilitationlaw.inventionRandomized controlled triallawHealth Status IndicatorsHumansMedicineRange of Motion ArticularCraniofacialPain MeasurementAnalysis of Variancebusiness.industryRehabilitationMiddle AgedTemporomandibular Joint DisordersManipulation OsteopathicClinical trialstomatognathic diseasesTreatment OutcomeStomatognathic systemComplementary and alternative medicineEtiologyPhysical therapyFemaleAnalysis of varianceManual therapybusinessRange of motionJournal of Bodywork and Movement Therapies
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