Search results for "complex systems"
showing 10 items of 73 documents
Proceedings della Sixth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS-2012)
2012
Proceedings della Fourth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS-2010)
2010
Stochastic dynamics of leukemic cells under an intermittent targeted therapy
2009
The evolutionary dynamics of cancerous cell populations in a model of Chronic Myeloid Leukemia (CML) is investigated in the presence of an intermittent targeted therapy. Cancer development and progression is modeled by simulating the stochastic evolution of initially healthy cells which can experience genetic mutations and modify their reproductive behavior, becoming leukemic clones. Front line therapy for the treatment of patients affected by CML is based on the administration of tyrosine kinase inhibitors, namely imatinib (Gleevec) or, more recently, dasatinib or nilotinib. Despite the fact that they represent the first example of a successful molecular targeted therapy, the development o…
Hitting Time Distributions in Financial Markets
2006
We analyze the hitting time distributions of stock price returns in different time windows, characterized by different levels of noise present in the market. The study has been performed on two sets of data from US markets. The first one is composed by daily price of 1071 stocks trade for the 12-year period 1987-1998, the second one is composed by high frequency data for 100 stocks for the 4-year period 1995-1998. We compare the probability distribution obtained by our empirical analysis with those obtained from different models for stock market evolution. Specifically by focusing on the statistical properties of the hitting times to reach a barrier or a given threshold, we compare the prob…
Structure and evolution of a European Parliament via a network and correlation analysis
2016
We present a study of the network of relationships among elected members of the Finnish parliament, based on a quantitative analysis of initiative co-signatures, and its evolution over 16 years. To understand the structure of the parliament, we constructed a statistically validated network of members, based on the similarity between the patterns of initiatives they signed. We looked for communities within the network and characterized them in terms of members' attributes, such as electoral district and party. To gain insight on the nested structure of communities, we constructed a hierarchical tree of members from the correlation matrix. Afterwards, we studied parliament dynamics yearly, wi…
n-cluster models in a transverse magnetic field
2017
In this paper we analize a family of one dimensional fully analytically solvable models, named the n-cluster models in a transverse magnetic field, in which a many-body cluster interaction competes with a uniform transverse magnetic field. These models, independently by the cluster size n + 2, exibit a quantum phase transition, that separates a paramagnetic phase from a cluster one, that corresponds to a nematic ordered phase or a symmetry-protected topological ordered phase for even or odd n respectively. Due to the symmetries of the spin correlation functions, we prove that these models have no genuine n+2-partite entanglement. On the contrary, a non vanishing concurrence arises between s…
General Systems Theory and Systems Biology
2015
We should not imagine that Systems Biology was born yesterday, indeed von Bertalanffy was a well-known supporter of the need to approach biological entities from the notion of a system. There is a tradition, dating back to early times, calling for the study of living things as a whole. Holism is no stranger to modern Systems Biology and, likewise, von Bertalanffy supported the quantitative study of the whole from the interaction of its parts.
Statistically validated networks in bipartite complex systems.
2011
Many complex systems present an intrinsic bipartite nature and are often described and modeled in terms of networks [1-5]. Examples include movies and actors [1, 2, 4], authors and scientific papers [6-9], email accounts and emails [10], plants and animals that pollinate them [11, 12]. Bipartite networks are often very heterogeneous in the number of relationships that the elements of one set establish with the elements of the other set. When one constructs a projected network with nodes from only one set, the system heterogeneity makes it very difficult to identify preferential links between the elements. Here we introduce an unsupervised method to statistically validate each link of the pr…
Mollusc shellomes: Past, present and future.
2020
13 pages; International audience; In molluscs, the shell fabrication requires a large array of secreted macromolecules including proteins and polysaccharides. Some of them are occluded in the shell during mineralization process and constitute the shell repertoire. The protein moieties, also called shell proteomes or, more simply, 'shellomes', are nowadays analyzed via high-throughput approaches. These latter, applied so far on about thirty genera, have evidenced the huge diversity of shellomes from model to model. They also pinpoint the recurrent presence of functional domains of diverse natures. Shell proteins are not only involved in guiding the mineral deposition, but also in enzymatic a…