Search results for "complex"

The Interaction of Small Molecules with Biomolecules

2014

The binding of small molecules with biological targets is associated to interesting chemical and biological properties of the resulting supramolecular systems. We have recently reported on the synthesis and characterization of cationic first row transition metal complexes and the study of their DNA binding properties, in aqueous solutions at neutral pH, essentially investigated by viscosimetry and spectroscopic techniques such as circular dichroism, absorption and fluorescence in the UV-visible wavelength range. Of course, such procedure cannot furnish atomic level details of the molecule-DNA interaction. Computational Chemistry may provide support for the interpretation of experimental dat…

Polarimetry as a useful tool for the study of binding equilibria between cyclodextrins and some suitably sized and structured organic molecules

Polarimetric study of binding equilibria between cyclodextrins and some suitable organic guests

Binding properties of polyaminocyclodextrin materials towards polyanions and p-nitroaniline derivatives

DOSE DEPENDENT SURVIVAL RESPONSE IN CHRONIC MYELOID LEUKEMIA UNDER CONTINUOUS AND PULSED TARGETED THERAPY

2010

A simulative study of cancer growth dynamics in patients affected by Chronic Myeloid Leukemia (CML), under the effect of a targeted dosedependent continuous or pulsed therapy, is presented. We have developed a model for the dynamics of CML in which thestochastic evolution of white blood cell populations are simulated by adopting a Monte Carlo approach. Several scenarios in the evolutionary dynamics of white blood cells, as a consequence of the efficacy of the different modelled therapies, pulsed or continuous, are described. The best results, in terms of a permanent disappearance of the leukemic phenotype, are achieved with a continuous therapy and higher dosage. However, our findings demon…

Giuseppe Samonà e la “spina dorsale” di Gibellina Nuova

2020

Nel 1970 Giuseppe Samonà coordina il gruppo di progettazione formato da Vittorio Gregotti, Gianni Pirrone e Alberto Samonà per il Progetto del Centro civico, commerciale e culturale di Gibellina Nuova. Del piano è realizzato il municipio e poi, rielaborato e in altro luogo, il teatro. I monumenti, fondati su un asse pedonale in quota connesso a un suolo artificiale articolato, esprimono l’unità architettura – urbanistica e anticipano, per certi versi, una riflessione successiva del Direttore dello IUAV sulla dialettica fra urbano e rurale.

Birkhoff's aesthetics, Arnheim's entropy. Some remarks on complexity and fuzzy entropy in arts

2015

A judgement of aesthetic in arts is, by sheer consensus, a daunting task that requires evaluation of a whole host of endogenous and exogenous cultural factors. A few of them can actually provide very useful hints in tackling foundational problems in Information Science in a more natural setting than what is usually provided by a typical engineering stance. This interaction can however work the other way about, as instruments from the Information and Computer Science toolkit may help in focusing the less explored features of art and its evaluation. When all the social, historical, hermeneutical and political considerations are stripped from the living flesh of the piece, we lose most of wha…

On the Evaluation of Images Complexity: A Fuzzy Approach (revised and expanded)

2006

The inherently multidimensional problem of evaluating the complexity of an image is of a certain relevance in both computer sci- ence and cognitive psychology. Computer scientists usually analyze spa- tial dimensions, to deal with automatic vision problems, such as feature- extraction. Psychologists seem more interested in the temporal dimension of complexity, to explore attentional models. Is it possible, by merging both approaches, to define an more general index of visual complexity? We have defined a fuzzy mathematical model of visual complexity, using a specific entropy function; results obtained by applying this model to pictorial images have a strong correlation with ones from an exp…

Attentional vs computational complexity measures in observing paintings

2008

Graph Comparison and Artificial Models for Simulating Real Criminal Networks

2021

Network Science is an active research field, with numerous applications in areas like computer science, economics, or sociology. Criminal networks, in particular, possess specific topologies which allow them to exhibit strong resilience to disruption. Starting from a dataset related to meetings between members of a Mafia organization which operated in Sicily during 2000s, we here aim to create artificial models with similar properties. To this end, we use specific tools of Social Network Analysis, including network models (Barabási-Albert identified to be the most promising) and metrics which allow us to quantify the similarity between two networks. To the best of our knowledge, the DeltaCo…