Search results for "component"

Eggshell types and their evolutionary correlation with life-history strategies in squamates

2015

The eggshell is an important physiological structure for the embryo. It enables gas exchange, physical protection and is a calcium reserve. Most squamates (lizards, snakes, worm lizards) lay parchment-shelled eggs, whereas only some gekkotan species, a subgroup of lizards, have strongly calcified eggshells. In viviparous (live-bearing) squamates the eggshell is reduced or completely missing (hereafter “shell-less”). Recent studies showed that life-history strategies of gekkotan species differ between species with parchment- and rigid-shelled eggshells. Here we test if the three different eggshell types found in the squamates are also associated with different life-history strategies. We fir…

Multivariate Methods and Molecular Modeling Techniques in the study of Antitumor Agents

2008

Two-step principal component analysis (PCA) as a method for separating auditory N1 and N250 elicited from 9-year-old children using a dense electrode…

2008

Detection of damage in civil engineering structures by PCA on enviromental vibration data

2018

The dynamic behavior of civil engineering structures are usually studied by means of ambient vibration observations and their performance is analyzed by Peak Picking and/or Operational Modal Analysis methods. This paper reports the first results of a statistical multivariate approach, specifically Principal Component Analysis, to detect a suspected structural damage on a sicilian highway bridge. Furthermore, the damage simulated in a simple structural model made it possible to understand the characteristics of the method consisting in comparing the observed data on an undamaged structure with those coming from a damaged one.

From Strategy to Code: Achieving Strategical Alignment in Software Development Projects Through Conceptual Modelling

2021

In this article we propose S2C, a strategy-to-code methodological approach to integrate organisational, business process, and information system modelling levels to support strategic alignment in software development. Through a model-driven approach and under the Conceptual-Model Programming paradigm, the proposal supports the semi-automatic generation of working software, as well as traceability among the modelling levels. Via a working example, we illustrate how strategic definitions can be traced into specific software components by the integration of three modelling methods: Lite*, for modelling strategic reaction to external influences, Communication Analysis, for business process mode…

El perfil profesional de los formadores de formación continua en España

2011

El objetivo de este trabajo es analizar y describir los perfiles profesionales del formador de formación continua en España. Con este propósito se ha elaborado un cuestionario estructurado que se ha aplicado de forma presencial a una muestra de 606 formadores a nivel nacional. El cuestionario ha proporcionado información sobre aspectos como el estatus socio-laboral del formador, el grado de profesionalización y la importancia de las competencias profesionales de los formadores. La información recabada ha sido analizada mediante métodos multivariantes para determinar los perfiles profesionales dominantes. El análisis cuantitativo incluye el Análisis de Componentes Principales Categóricos (CA…

EmPeCemos: un programa multicomponente para la prevención indicada de los problemas de conducta y el abuso de drogas

2009

En la última década, un amplio número de investigaciones ha permitido constatar la existencia de trayectorias de desarrollo desadaptativas, asociadas a problemas de conducta de inicio temprano. Estas trayectorias, en las que se implica una compleja cadena de factores familiares, escolares y socioemocionales, dan lugar a desajustes comportamentales crónicos y severos, de difícil tratamiento, incluyendo comportamientos antisociales y abuso de drogas. Por ello, la investigación en prevención subraya la necesidad de una intervención temprana que, actuando sobre los individuos en alto riesgo y su entorno, permita detener el avance hacia patrones severos de desadaptación. En esta línea, se desarr…

Characterization of the atmospheric muon flux in IceCube

2015

Muons produced in atmospheric cosmic ray showers account for the by far dominant part of the event yield in large-volume underground particle detectors. The IceCube detector, with an instrumented volume of about a cubic kilometer, has the potential to conduct unique investigations on atmospheric muons by exploiting the large collection area and the possibility to track particles over a long distance. Through detailed reconstruction of energy deposition along the tracks, the characteristics of muon bundles can be quantified, and individual particles of exceptionally high energy identified. The data can then be used to constrain the cosmic ray primary flux and the contribution to atmospheric …

Special Issue on “Proteostasis and Autophagy”

2019

Autophagy is a highly conserved eukaryotic pathway responsible for the lysosomal degradation (and subsequent recycling) of cellular components such as proteins, protein aggregates, and a growing number of organelles or cellular compartments [...]

Reconstructing the free-energy landscape of Met-enkephalin using dihedral principal component analysis and well-tempered metadynamics

2013

Well-Tempered Metadynamics (WTmetaD) is an efficient method to enhance the reconstruction of the free-energy surface of proteins. WTmetaD guarantees a faster convergence in the long time limit in comparison with the standard metadynamics. It still suffers however from the same limitation, i.e. the non trivial choice of pertinent collective variables (CVs). To circumvent this problem, we couple WTmetaD with a set of CVs generated from a dihedral Principal Component Analysis (dPCA) on the Ramachadran dihedral angles describing the backbone structure of the protein. The dPCA provides a generic method to extract relevant CVs built from internal coordinates. We illustrate the robustness of this …