Search results for "computational"
showing 10 items of 5884 documents
Formulations and exact algorithms for the distance-constrained generalized directed rural postman problem
2017
[EN] The generalized directed rural postman problem is an arc routing problem with many interesting real-life applications, such as routing for meter reading. In this application, a vehicle with a receiver travels through a series of neighborhoods. If the vehicle gets closer than a certain distance to a meter, the receiver is able to record the gas, water, or electricity consumption. Therefore, the vehicle does not need to traverse every street, but only a few, to get close enough to each meter. We study an extension of this problem in which a fleet of vehicles is available. Given the characteristics of the mentioned application, the vehicles have no capacities but there is a maximum distan…
Pactos de carácter patrimonial en las uniones de hecho: un estudio de la cuestión desde la perspectiva de la experiencia jurídica española
2019
This paper studies the matter of the validity of patrimonial agreements in common-law relationships in Spanish Law
El pensamiento computacional en contextos educativos: una aproximación desde la Tecnología Educativa
2019
El pensamiento computacional ha vivido un resurgir en los últimos años, en los que la comunidad científica y educativa ha puesto su foco de interés sobre él como un aspecto relevante a incorporar de manera curricular. No obstante, la falta de consenso respecto a qué es y cómo trabajarlo tiene como resultado que se aborde de diferentes formas en la educación, lo que repercute directamente en el aprendizaje del alumnado. Desde enfoques más técnicos, que tienen el riesgo de no permitir aprovechar el potencial que tiene de ser integrado en la estrategia didáctica del docente, a enfoques más transversales, que sí profundizan en las posibilidades que tiene en el ámbito de la didáctica, pero que a…
A low complexity distributed cluster based algorithm for spatial prediction
2017
Los mapas del entorno radioeléctrico (REM) pueden ser una herramienta esencial para numerosas aplicaciones en las futuras redes inalámbricas 5G. En este trabajo, empleamos un popular método geoestadístico llamado kriging ordinario para estimar el REM de un área cubierta por un eNodeB equipado con múltiples antenas. Los sensores inalámbricos se distribuyen por el área de interés y se organizan clústeres adaptativos de sensores para mejorar la calidad de la estimación del canal. En este trabajo, modificamos el algoritmo de clustering distribuido propuesto en un trabajo anterior para reducir la complejidad de la predicción de kriging. Se realizan simulaciones para detallar la técnica de formac…
Deciphering genomic heterogeneity and the internal composition of tumour activities through a hierarchical factorisation model
2021
Genomic heterogeneity constitutes one of the most distinctive features of cancer diseases, limiting the efficacy and availability of medical treatments. Tumorigenesis emerges as a strongly stochastic process, producing a variable landscape of genomic configurations. In this context, matrix factorisation techniques represent a suitable approach for modelling such complex patterns of variability. In this work, we present a hierarchical factorisation model conceived from a systems biology point of view. The model integrates the topology of molecular pathways, allowing to simultaneously factorise genes and pathways activity matrices. The protocol was evaluated by using simulations, showing a hi…
A tribute to Massimo Lanza de Cristoforis
2020
It is with great pleasure that we dedicate the special issue Functional Analytic Methods in Partial Differential Equations of Complex Variables and Elliptic Equations to the 60th birthday of Massim...
Large numbers of cold positronium atoms created in laser-selected Rydberg states using resonant charge exchange
2016
Lasers are used to control the production of highly excited positronium atoms (Ps*). The laser light excites Cs atoms to Rydberg states that have a large cross section for resonant charge-exchange collisions with cold trapped positrons. For each trial with 30 million trapped positrons, more than 700 000 of the created Ps* have trajectories near the axis of the apparatus, and are detected using Stark ionization. This number of Ps* is 500 times higher than realized in an earlier proof-of-principle demonstration (2004 Phys. Lett. B 597 257). A second charge exchange of these near-axis Ps* with trapped antiprotons could be used to produce cold antihydrogen, and this antihydrogen production is e…
Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells
2015
Abstract Background Cancer is a complex disease with multiple genetic and epigenetic alterations. Since decades, the hallmark of cancer therapy is chemotherapy. Cytotoxic drugs erase rapidly dividing cells without sufficient differentiation between normal and cancerous cells resulting in severe side effects in normal tissues. Recently, strategies for cancer treatment focused on targeting specific proteins involved in tumor growth and progression. The present study was designed to investigate the cytotoxicity of 65 crude extracts from 35 Sudanese medicinal plants towards various cancer cell lines expressing molecular mechanisms of resistance towards classical chemotherapeutics (two ATP-bindi…
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract
Theoretical study of photoinduced ring-isomerization in the 1,2,4-oxadiazole series
2004
Abstract A theoretical study of photoinduced ring-isomerization of 3-amino-5-methyl- and 3-amino-5-phenyl-1,2,4-oxadiazoles is reported. The results well agree with the reported experimental data: in particular, they explain the ring-photoisomerization into the corresponding 2-amino-1,3,4-oxadiazoles through a ring contraction-ring expansion route; moreover, the occurrence of competing pathways involving both the ring contraction and the internal cyclization–isomerization mechanism during irradiation of the 5-alkyl substituted substrates in the presence of a base has been also substantiated.