Search results for "computer simulation"
showing 10 items of 1054 documents
Mechanics of invagination and folding: Hybridized instabilities when one soft tissue grows on another
2015
We address the folding induced by differential growth in soft layered solids via an elementary model that consists of a soft growing neo-Hookean elastic layer adhered to a deep elastic substrate. As the layer/substrate modulus ratio is varied from above unity towards zero we find a first transition from supercritical smooth folding followed by cusping of the valleys to direct subcritical cusped folding, then another to supercritical cusped folding. Beyond threshold the high amplitude fold spacing converges to about four layer thicknesses for many modulus ratios. In three dimensions the instability gives rise to a wide variety of morphologies, including almost degenerate zigzag and triple-ju…
The interplay between cooperativity and diversity in model threshold ensembles
2014
The interplay between cooperativity and diversity is crucial for biological ensembles because single molecule experiments show a significant degree of heterogeneity and also for artificial nanostructures because of the high individual variability characteristic of nanoscale units. We study the cross-effects between cooperativity and diversity in model threshold ensembles composed of individually different units that show a cooperative behaviour. The units are modelled as statistical distributions of parameters (the individual threshold potentials here) characterized by central and width distribution values. The simulations show that the interplay between cooperativity and diversity results …
Nonlinear nystagmus processing causes torsional VOR nonlinearity.
2003
The eye movement component that rotates around the line of sight, i.e., the ocular torsion, is in many aspects different from horizontal and vertical eye movements. While ocular torsion is mediated only by reflexive pathways like the torsional vestibulo-ocular and optokinetic reflexes (TVOR and OKN, respectively), horizontal and vertical components are also subject to intentional control mechanisms that are mediated by the saccadic and the pursuit systems. Dynamic properties of torsional eye movements are also very distinct. While horizontal and vertical VOR components show a gain close to unity and a small neural integration leakage with a time constant around pi=30 s, the TVOR shows a sma…
Estimation of the mechanical properties of the eye through the study of its vibrational modes.
2017
Measuring the eye's mechanical properties in vivo and with minimally invasive techniques can be the key for individualized solutions to a number of eye pathologies. The development of such techniques largely relies on a computational modelling of the eyeball and, it optimally requires the synergic interplay between experimentation and numerical simulation. In Astrophysics and Geophysics the remote measurement of structural properties of the systems of their realm is performed on the basis of (helio-)seismic techniques. As a biomechanical system, the eyeball possesses normal vibrational modes encompassing rich information about its structure and mechanical properties. However, the integral a…
Spatial response spectra and site amplification effects
2002
A simplified analysis of local site amplification effects on the seismic response of multi-support structures is presented. The site effects are modeled by considering reflections and transmission of vertically propagating shear waves from bedrock to the surface through a soil layer. A random vibration-based response spectrum of a simple oscillator on two supports, one of which is founded on rock outcrop and the other on soil layer, is formulated in order to study the influence of non-uniform excitations on multi-support structures. Joint inertial and pseudo-static effects in the overall response are studied in detail. The resulting response spectra are formulated as displacement and force …
The assessment of volcanic gas hazard by means of numerical models: An example from Vulcano Island (Sicily)
1999
Volcanic activity can inject large quantities of gases and aerosols into the atmosphere both during and between eruptions, creating a health risk for the local population. The paper describes how the volcanic gas concentration in the air can be computed by a flow model simulating the wind field over a digital terrain model of the volcano coupled with a Lagrangian particle model that uses the known (measured) gas emission rates to simulate gas dispersion. The coupling provides hazard maps for a number of meteorological conditions, introduced as boundary and initial conditions to the wind flow model, and permits the estimation of the risk both for actual and increased emission rates. An appli…
Directionlets: Anisotropic Multidirectional representation with separable filtering
2006
In spite of the success of the standard wavelet transform (WT) in image processing in recent years, the efficiency of its representation is limited by the spatial isotropy of its basis functions built in the horizontal and vertical directions. One-dimensional (1-D) discontinuities in images (edges and contours) that are very important elements in visual perception, intersect too many wavelet basis functions and lead to a nonsparse representation. To efficiently capture these anisotropic geometrical structures characterized by many more than the horizontal and vertical directions, a more complex multidirectional (M-DIR) and anisotropic transform is required. We present a new lattice-based pe…
Effects of menu structure and touch screen scrolling style on the variability of glance durations during in-vehicle visual search tasks.
2011
The effects of alternative navigation device display features on drivers' visual sampling efficiency while searching forpoints of interest were studied in two driving simulation experiments with 40 participants. Given that the number of display items was sufficient, display features that facilitate resumption of visual search following interruptions were expected to lead to more consistent in-vehicle glance durations. As predicted, compared with a grid-style menu, searching information in a list-style menu while driving led to smaller variance in durations of in-vehicle glances, in particular with nine item displays. Kinetic touch screen scrolling induced a greater number of very short in-v…
Structural Origin of Metal Specificity in Isatin Hydrolase from Labrenzia aggregata Investigated by Computer Simulations.
2017
We performed quantum-chemical calculations, ab initio molecular dynamics, hybrid quantum mechanics/molecular mechanics (QM/MM) and enhanced sampling metadynamics simulations to investigate the origin of metal specificity in isatin hydrolase from Labrenzia aggregata. The peculiar octahedral binding geometry of the Mn2+ ion in the Michaelis complex includes both the isatin substrate and the catalytic water within the first coordination shell of the cation. Our calculations show that the same arrangement of the ligands cannot be efficiently achieved in the presence of other small divalent metal cations such as Zn2+ or Cu2+ . On the contrary, bulkier alkaline-earth cations such as Mg2+ , which …
Nitrated Fatty Acids Modulate the Physical Properties of Model Membranes and the Structure of Transmembrane Proteins
2017
Nitrated fatty acids (NO2 -FAs) act as anti-inflammatory signal mediators, albeit the molecular mechanisms behind NO2 -FAs' influence on diverse metabolic and signaling pathways in inflamed tissues are essentially elusive. Here, we combine fluorescence measurements with surface-specific sum frequency generation vibrational spectroscopy and coarse-grained computer simulations to demonstrate that NO2 -FAs alter lipid organization by accumulation at the membrane-water interface. As the function of membrane proteins strongly depends on both, protein structure as well as membrane properties, we consecutively follow the structural dynamics of an integral membrane protein in presence of NO2 -FAs. …