Search results for "computing"

showing 10 items of 25279 documents

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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The value of peri-urban landscapes in a French real estate market

2011

Co-éditions : Wiley, Hoboken, USA; International audience; Nous étudions le prix hédoniste de paysages périurbains dans la région de Dijon (France) à partir de données individuelles de transactions de maisons, géoréférencées pour permettre de les apparier avec des données géographiques sur les paysages. Des variables paysagères sont constituées en calculant le paysage vu depuis le sol autour de ces maisons : plans de vision selon leur éloignement (six horizons sont distingués) et contenu de ceux-ci décliné en douze types d’occupation du sol. Les résultats montrent que la vue proprement dite compte, car les objets présents à proximité des maisons mais non vus ont un prix hédoniste inférieur …

ATTRIBUTS PAYSAGERSVALEUR PAYSAGEREPAYSAGE PERIURBAINVUE PAYSAGEREPRIX HEDONIQUE[SHS.GEO]Humanities and Social Sciences/Geography[SHS] Humanities and Social SciencesComputingMilieux_MISCELLANEOUS[ SHS.GEO ] Humanities and Social Sciences/Geography[SHS]Humanities and Social Sciences
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Co-maternité : entre désir et réalité

2011

International audience

AUTORITE PARENTALE[SHS.DROIT]Humanities and Social Sciences/LawDroit de visite et d'hébergement[SHS.DROIT] Humanities and Social Sciences/LawTiersCouple homosexuelIntérêt de l'enfantComputingMilieux_MISCELLANEOUS
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Dynamic Magnetic and Optical Insight into a High Performance Pentagonal Bipyramidal Dy(III) Single-Ion Magnet

2017

The pentagonal bipyramidal single-ion magnets (SIMs) are among the most attractive prototypes of high-performance single-molecule magnets (SMMs). Here, a fluorescence-active phosphine oxide ligand CyPh2PO (=cyclohexyl(diphenyl)phosphine oxide) was introduced into [Dy(CyPh2PO)2(H2O)5]Br3⋅2 (CyPh2PO)⋅EtOH⋅3 H2O, and combined dynamic magnetic measurement, optical characterization, ab initio calculation, and magneto-optical correlation of this high-performance pseudo-D5h DyIII SIM with large Ueff (508(2) K) and high magnetic hysteresis temperature (19 K) were performed. This work provides a deeper insight into the rational design of promising molecular magnets.

Ab initioNanotechnology010402 general chemistry01 natural sciencesCatalysisdynamic magnetic measurementschemistry.chemical_compoundPentagonal bipyramidal molecular geometry[CHIM]Chemical SciencesPhysics::Chemical Physicssingle-molecule magnetsta116ComputingMilieux_MISCELLANEOUSPhosphine oxideSingle ionMolecular magnets010405 organic chemistryLigandOrganic ChemistryGeneral ChemistryMagnetic hysteresis0104 chemical sciencesCrystallographychemistryMagnetmolecular magnetsChemistry: A European Journal
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Les déterminants de l'abandon en thèse : étude à partir de l'enquête Génération 98 du Céreq

2003

International audience

AbandonDéterminant[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationFranceThèseComputingMilieux_MISCELLANEOUSEnseignement supérieur
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L'abandon enseignant : travail, opportunités, parcours

2016

National audience

AbandonReconversion professionnelleParcours professionnel[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/Education[ SHS.EDU ] Humanities and Social Sciences/EducationEnseignantComputingMilieux_MISCELLANEOUSDémissionParcours de formation
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Towards a Comprehension of University Dropout in Catalonia: the Case of Universitat Autònoma de Barcelona

2015

The article presents the results of a research that aims to unfold the reasons behind students’ dropout at the Autonomous University of Barcelona (UAB). Data is analyzed, and interviews and focus groups with students who have dropout, study degree’s coordinators and institutional authorities are carried out. Results indicate that part of the abandonment taking place is voluntary, natural and even necessary, when the student does not enter the desired option or discovers that the studies do not fi t with their vocational interests, but it also represents a misalignment between the academic offer and the students’ capabilities, performance and motivation.

Abandonment (legal)abandonoFocus groupretenciónEducationVocational educationPedagogyComputingMilieux_COMPUTERSANDEDUCATIONestudiantesSociologylcsh:LDropout (neural networks)universidadlcsh:EducationEstudios sobre Educación
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Une fondation canoniale réformatrice : la collégiale Saint-Martin de Miséré et ses dépendances (XIe-XIIIe siècle)

2015

International audience

AbbéHistoirePrieuréMoyen ÂgeCollégiale[ SHS.HIST ] Humanities and Social Sciences/History[SHS.HIST] Humanities and Social Sciences/History[ SHS ] Humanities and Social Sciences[SHS] Humanities and Social Sciencesévêché[SHS.HIST]Humanities and Social Sciences/HistoryComputingMilieux_MISCELLANEOUS[SHS]Humanities and Social Sciences
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Computing abelian periods in words

2011

International audience

Abelian period Abelian repetition weak repetition design of algorithms text algorithms combinatorics on words[INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS]ComputingMilieux_MISCELLANEOUS
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The large trans-Neptunian object 2002 TC 302 from combined stellar occultation, photometry, and astrometry data

2020

All authors: Ortiz, J. L.; Santos-Sanz, P.; Sicardy, B.; Benedetti-Rossi, G.; Duffard, R.; Morales, N.; Braga-Ribas, F.; Fernández-Valenzuela, E.; Nascimbeni, V.; Nardiello, D.; Carbognani, A.; Buzzi, L.; Aletti, A.; Bacci, P.; Maestripieri, M.; Mazzei, L.; Mikuz, H.; Skvarc, J.; Ciabattari, F.; Lavalade, F. Scarfi, G.; Mari, J. M.; Conjat, M.; Sposetti, S.; Bachini, M.; Succi, G.; Mancini, F.; Alighieri, M.; Dal Canto, E.; Masucci, M.; Vara-Lubiano, M.; Gutiérrez, P. J.; Desmars, J.; Lecacheux, J.; Vieira-Martins, R.; Camargo, J. I. B.; Assafin, M.; Colas, F.; Beisker, W.; Behrend, R.; Mueller, T. G.; Meza, E.; Gomes-Junior, A. R.; Roques, F.; Vachier, F.; Mottola, S.; Hellmich, S.; Campo …

Absolute magnitude010504 meteorology & atmospheric sciencesFOS: Physical sciencesAstrophysicsKuiper belt objects: individual: 2002 TC30201 natural sciencesOccultationlaw.inventionTelescopePhotometry (optics)lawGeometric albedoFísica Aplicada0103 physical sciencesTrans-Neptunian object010303 astronomy & astrophysicsComputingMilieux_MISCELLANEOUS0105 earth and related environmental sciencesPhysics[PHYS]Physics [physics]Earth and Planetary Astrophysics (astro-ph.EP)photometric [Techniques]Astronomy and Astrophysicsgeneral [Kuiper belt]Astrometryindividual: 2002 TC302 [Kuiper belt objects]AstrometryAstrometry; Kuiper belt objects: individual: 2002 TC302; Kuiper belt: general; Occultations; Techniques: photometricLight curveSpace and Planetary Science[SDU]Sciences of the Universe [physics]Kuiper belt: generalOccultations[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]Techniques: photometricAstrophysics - Earth and Planetary AstrophysicsAstronomy & Astrophysics
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