Search results for "computing"
showing 10 items of 25279 documents
Tout ce que les avocats ont toujours voulu savoir sur le plagiat..
2013
International audience
A novel function of Huntingtin in the cilium and retinal ciliopathy in Huntington's disease mice
2015
Huntington's disease (HD) is a neurodegenerative disorder caused by the toxic expansion of polyglutamine in the Huntingtin (HTT) protein. The pathomechanism is complex and not fully understood. Increasing evidence indicates that the loss of normal protein function also contributes to the pathogenesis, pointing out the importance of understanding the physiological roles of HTT. We provide evidence for a novel function of HTT in the cilium. HTT localizes in diverse types of cilia — including 9 + 0 non-motile sensory cilia of neurons and 9 + 2 motile multicilia of trachea and ependymal cells — which exert various functions during tissue development and homeostasis. In the photoreceptor cilium,…
Azole-resistant Aspergillus fumigatus: A global phenomenon originating in the environment?
2019
Abstract Aspergillus fumigatus is the predominant etiological agent of invasive aspergillosis (IA), a difficult-to-manage fungal disease associated with a high case fatality rate. Azole antifungals, particularly voriconazole, have significantly improved the survival rate of patients with IA. However, the clinical advances made possible through the use of medical azoles could be threatened by the emergence of azole-resistant strains which has been reported in an ever-increasing number of countries over the last 10 years. The major resistance mechanism, that combines point mutation(s) in the coding sequence of cyp51A gene and an insertion of a tandem repeat in the promoter region of this gene…
Choosing the Right Antifungal Agent in ICU Patients
2019
Fungi are responsible for around 20% of microbiologically documented infections in intensive care units (ICU). In the last decade, the incidence of invasive fungal infections (IFI), including candidemia, has increased steadily because of increased numbers of both immunocompromised and ICU patients. To improve the outcomes of patients with IFI, intensivists need to be aware of the inherent challenges. This narrative review summarizes the features of routinely used treatments directed against IFI in non-neutropenic ICU patients, which include three classes of antifungals: polyenes, azoles, and echinocandins. ICU patients' pathophysiological changes are responsible for deep changes in the phar…
Ciutat, telecomunicacions i informació
1997
This paper offers some ideas and reflections around the impact of the telecommunications and considers how the telecommunications affect to the economic growth of the cities.
The Belle II Physics Book
2019
cd. autorów: L. Cao48,‡, G. Caria145,‡, G. Casarosa57,‡, C. Cecchi56,‡,D. Cˇ ervenkov10,‡,M.-C. Chang22,‡, P. Chang92,‡, R. Cheaib146,‡, V. Chekelian83,‡, Y. Chen154,‡, B. G. Cheon28,‡, K. Chilikin77,‡, K. Cho70,‡, J. Choi14,‡, S.-K. Choi27,‡, S. Choudhury35,‡, D. Cinabro170,‡, L. M. Cremaldi146,‡, D. Cuesta47,‡, S. Cunliffe16,‡, N. Dash33,‡, E. de la Cruz Burelo9,‡, E. de Lucia52,‡, G. De Nardo54,‡, †Editor. ‡Belle II Collaborator. §Theory or external contributing author. M. De Nuccio16,‡, G. De Pietro59,‡, A. De Yta Hernandez9,‡, B. Deschamps129,‡, M. Destefanis60,‡, S. Dey116,‡, F.Di Capua54,‡, S.Di Carlo75,‡, J. Dingfelder129,‡, Z. Doležal10,‡, I. Domínguez Jiménez125,‡, T.V. Dong30,26,…
Corporate governance and determinants that explain CEO compensation in Indonesia
2011
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2011 This thesis examines determinants that can help explain CEO remuneration in an Asian emerging market, focusing on Indonesia. Our sample consists of 46 Indonesian stock listed companies, and we use data from recently expanded rules on disclosure to analyze the level and structure of compensation for the CEO - domestically known as the president director. Looking at corporate governance arrangements, firm performance, and CEO characteristics, our empirical evidence reveals a significant positive relationship between firm size and CEO pay. No further significant relationships are found between CEO compensation and our remai…
Determinants of CEO compensation in Pakistan from 2007 to 2009
2010
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2010 Most studies of the determinants of executive compensation are based on the experience of developed countries. This paper examines the relationship between firm size, firm performance and board composition on CEO compensation, in the context of an emerging and developing economy of Pakistan. Data for 83 listed firms from Lahore stock exchange, Pakistan has been used for 2007 to 2009. The findings show that firm size is one of the major determining factors of CEO compensation rather than performance. A family recruited CEO has a negative and significant effect upon the CEO compensation. In this study we also look at a num…
The impact of job satisfaction on perceived desirability of leaving : a study in cable manufacturing organizations in Sri Lanka
2011
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2011 The job satisfaction level is a key determinant for the employees’ leaving or retention decisions. The satisfied employees have a tendency to stay in the organization while the dissatisfied employees have a greater tendency to leave the organization. The research study on impact of job satisfaction on perceived desirability of leaving was conducted by selecting the executive level employees in cable manufacturing industry in Sri Lanka. The main objective of this study was to examine the impact of job satisfaction on perceived desirability of leaving. This was split into three sub objectives as; to examine the type of rel…
Online consumer behavior among Norwegian business students
2013
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2013 E-commerce is an ever growing phenomenon which merits further research. This study conducts a literature review in the field of online consumer behavior, focusing on online consumer purchase intention and online consumer loyalty in the context of Norwegian business students. We also conduct a survey with 196 business students in Norway, and go on to identify three important variables impacting online consumer purchase intention; online trust, previous online purchase experience and social media interaction, and two important variables impacting online consumer loyalty; online shopping enjoyment and online satisfaction. R…