Search results for "conditioning"

Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: old and new vistas.

2011

The possible involvement of salsolinol (Sal), an endogenous condensation product of ACD (the first metabolite of ethanol) and dopamine, in the neurochemical basis underlying ethanol action has been repeatedly suggested although it has not been unequivocally established, still being a controversial matter of debate. The main goal of this review is to evaluate the presumed contribution of Sal to ethanol effects summarizing the reported data since the discovery in the 1970s of Sal formation in vitro during ethanol metabolism until the more recent studies characterizing its behavioral and neurochemical effects. Towards this end, we first analyze the production and detection of Sal, in different…

Irisin: A new potential hormonal target for the treatment of obesity and type 2 diabetes

2012

Release of choline in the isolated heart, an indicator of ischemic phospholipid degradation and its protection by ischemic preconditioning: No eviden…

2003

Abstract The release of choline as a water-soluble product of phospholipid hydrolysis was measured in the perfusate of rat hearts to monitor ischemic membrane degradation and its protection by ischemic preconditioning (IPC). Hearts were subjected to global ischemia (GI; 30 min of no-flow) followed by 60 min of reperfusion. To induce IPC, GI was preceded by four no-flow episodes of 5 min each. Deleterious consequences of GI and reperfusion, namely coronary flow reduction, incidence of arrhythmias and release of cardiac troponin T, were significantly attenuated by IPC. The release of choline increased during reperfusion in a biphasic manner: a first phase peaked immediately after GI and was f…

Effects of chronic exercise on myocardial refractoriness: a study on isolated rabbit heart

2008

Aim:  To determine whether chronic physical training increases atrial and ventricular refractoriness in isolated rabbit heart. Methods:  Trained rabbits were submitted to a protocol of treadmill running. The electrophysiological parameters of refractoriness investigated in an isolated heart preparation were: (1) atrial effective refractory period (AERP) and atrial functional refractory period and ventricular effective and functional refractory periods (VERP and VFRP) using the extrastimulus technique at four different pacing cycle lengths; (2) the dominant frequency (DF) of ventricular fibrillation (VF). A multi-electrode plaque containing 256 electrodes and a spectral method were used to o…

Wavelet-like bases for thin-wire integral equations in electromagnetics

2005

AbstractIn this paper, wavelets are used in solving, by the method of moments, a modified version of the thin-wire electric field integral equation, in frequency domain. The time domain electromagnetic quantities, are obtained by using the inverse discrete fast Fourier transform. The retarded scalar electric and vector magnetic potentials are employed in order to obtain the integral formulation. The discretized model generated by applying the direct method of moments via point-matching procedure, results in a linear system with a dense matrix which have to be solved for each frequency of the Fourier spectrum of the time domain impressed source. Therefore, orthogonal wavelet-like basis trans…

Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

2021

Abstract Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of…

Housing conditions modulate the reinforcing properties of cocaine in adolescent mice that binge on fat

2017

Abstract Binge eating is a specific form of overeating characterized by intermittent, excessive eating. To date, several studies have addressed the effects that bingeing on fat has on the rewarding effects of drugs of abuse, but they have found contradictory and highly variable results. Housing conditions could modulate these results, as most studies employ isolated animals to measure the exact amount of food that is ingested. The aim of this study was to evaluate the effects of housing conditions on the response of mice to cocaine, modulated by bingeing on a high-fat diet during adolescence. After 40 days of binge-eating for 2 h, three days a week (PND 29–69), the reinforcing effects of a …

ELISA: A simplified tool for evaluating the Environmental Life-cycle Impacts of Solar Air-conditioning systems

2018

The paper presents ELISA, a simplified tool for estimating the Environmental Life-cycle Impacts of Solar Air-conditioning systems. The tool is designed to support researchers, designers and decision makers in a simplified evaluation of the life cycle energy and environmental potential benefits related to the installation of solar heating and cooling systems in substitution of conventional ones. The tool was developed within the research activities of Task 53 “New Generation Solar Cooling & Heating Systems (PV or solar thermally driven systems)” of the International Energy Agency.

Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu

2017

AbstractPhysical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, the role of physical activity in acute liver injury is poorly explored. To study the role of physical activity in acute liver injury, a novel model of voluntary distance running in mice was developed and mice were subjected to acute liver injury induced by N-galactosamine (GalN) and lipopolysaccharide (LPS). Analyses included histological stains, immunoblotting, qRT-PCR and FACS analysis. Voluntary distance running increased to an average of 10.3 km/day after a learning curve. Running lead to a decrease in the absolute numbers of intrahepatic CD4+ T and B lymphocy…

How an idea germinates into a projext or the intransitive resultative construction with Entity-Specific change-of-state verbs

2014

[EN] This study discusses how seven of Levin’s (1993) entity-specific change-of-state verbs (i.e. bloom, blossom, flower, germinate, sprout, swell, and blister) are subsumed into the intransitive resultative construction by highlighting and making use of the external and internal constraints proposed by the Lexical Constructional Model (LCM; Ruiz de Mendoza and Mairal 2007). External constraints refer to cognitive mechanisms such as high-level metaphor and/or metonymy whereas internal constraints are concerned with the encyclopedic and event structure makeup of verbs. The Internal Variable Conditioning constraint is at work when the information encapsulated by a predicate determines the cho…