Search results for "connective"
showing 10 items of 1122 documents
Roles of adenosine and cytosine methylation changes and genetic mutations in adaptation to different temperatures
2019
Abstract Epigenetic modifications have been found to be involved in evolution, but the relative contributions of genetic and epigenetic variation in adaptation are unknown. Furthermore, previous studies on the role of epigenetic changes in adaptation have nearly exclusively focused on cytosine methylation in eukaryotes. We collected phenotypic, genetic, and epigenetic data from populations of the bacterium Serratia marcescens that had undergone experimental evolution in contrasting temperatures to investigate the relationship between environment, genetics, epigenetic, and phenotypic traits. The genomic distribution of methylated adenosines (m6A) pointed to their role in regulation of gene e…
MOESM1 of Longitudinal association of changes in diet with changes in body weight and waist circumference in subjects at high cardiovascular risk: th…
2019
Additional file 1: Figure S1. Flow chart summarizing selection of PREDIMED participants for the present study. Figure S2. Directed acyclic graph (DAG). Table S1. Characterization of food items belonging to each food group. Table S2. Correlations matrix between food groups (serving/d) within each global dietary score (GDS). Table S3. Sensitivity analyses: Association of yearly changes in food groups intake with concurrent changes in waist circumference over 5-year of follow-up by sex. Table S4. Sensitivity analysis: association of changes in global dietary score (GDS) with body weight and waist circumference changes over 5-year of follow-up. Table S5. Sensitivity analysis: association of cha…
Additional file 1 of The effects of rapid weight loss on skeletal muscle in judo athletes
2020
Additional file 1. Changes in body weight and biomarkers.
Additional file 1: of Identification of key genes and its chromosome regions linked to drought responses in leaves across different crops through met…
2019
Table S1. The table consists of gene_ID, corresponding arabidopsis orthologs and log2 fold change values for significantly regulated genes (FDRâ
The many ways topography buffers responses to climate change
2018
During climate change, populations have two survival options - they can remain in situ and tolerate the new climatic conditions ('stay'), or they can migrate to track their climatic niches elsewhere ('go'). Staying requires broad climatic tolerances, niche shifts due to changing biotic interactions, acclimation through plasticity, or rapid genetic adaptation. Going, in contrast, requires good dispersal and colonization capacities. However, both the magnitude of climate change experienced locally and the capacities required for staying or going in response to climate change are not constant across landscapes, but affected by local microclimatic variation associated with topographic complexit…
Changes in anterior chamber eye during accommodation as assessed using a Dual Scheimpflug system
2018
Purpose: To study the changes in anterior chamber depth (ACD), anterior chamber angle (ACA), and pupil diameter (PD) during accommodation. Methods: Eighty eyes of 80 subjects, aged 22 to 40 years, were included. The rotating Dual Scheimpflug and a Placido disc system (Galilei G4, Ziemer Ophthalmic Systems AG, Switzerland) was used to measure the changes in ACD, ACA, and PD during accommodation. ACD measurement was taken for the central zone and for 4 more positions, each in different orientation (nasal, superior, temporal and inferior), 4 mm away from the centre. ACA was measured for the whole eye as well for the nasal, superior, temporal, and inferior quadrants. These metrics were obtained…
Additional file 1 of Anti-SARS-CoV-2 IgA and IgG in human milk after vaccination is dependent on vaccine type and previous SARS-CoV-2 exposure: a lon…
2022
Additional file 1: Table S1. Reported maternal and infant side-effects after vaccination. Table S2. Results from the longitudinal mixed-effects analysis modeling the changes in IgG and IgA detection in human breast milk after vaccination. Figure S1. Individual trajectories of the SARS-CoV-2 IgG in breast milk samples according to vaccine from baseline (before the 1st dose) to 3-4 weeks post vaccination course (A-C) and grouped by vaccine (D-F). Data is presented as log-transformed arbitrary units (AU) and AU ± 95% CI. Figure S2. Individual trajectories of the SARS-CoV-2 IgA in breast milk samples according to vaccine from baseline transformed arbitrary units (AU) and AU ± 95% CI. Table S3. …
Additional file 8: of Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of …
2019
Figure S5. Changes in cellular composition due to Etanercept treatment before, during, and after treatment. Comparison of the abundance of various cell types in the lesional and non-lesional skin of patients with psoriasis. Expression data from dataset GSE47751 was used for this analysis. The p-values of each comparison are presented above each box in the boxplots. (PDF 701 kb)
Loss of circadian clock gene expression is associated with tumor progression in breast cancer
2015
Several studies suggest a link between circadian rhythm disturbances and tumorigenesis. However, the association between circadian clock genes and prognosis in breast cancer has not been systematically studied. Therefore, we examined the expression of 17 clock components in tumors from 766 node-negative breast cancer patients that were untreated in both neoadjuvant and adjuvant settings. In addition, their association with metastasis-free survival (MFS) and correlation to clinicopathological parameters were investigated. Aiming to estimate functionality of the clockwork, we studied clock gene expression relationships by correlation analysis. Higher expression of several clock genes (e.g., C…
Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
2012
<p>Introduction: Cis-acting regulatory single nucleotide polymorphisms (SNPs) at specific loci may modulate penetrance of germline mutations at the same loci by introducing different levels of expression of the wild-type allele. We have previously reported that BRCA2 shows differential allelic expression and we hypothesize that the known variable penetrance of BRCA2 mutations might be associated with this mechanism.</p>\ud \ud <p>Methods: We combined haplotype analysis and differential allelic expression of BRCA2 in breast tissue to identify expression haplotypes and candidate cis-regulatory variants. These candidate variants underwent selection based on in silico predicti…