Search results for "construct"
showing 10 items of 3723 documents
How to avoid collision between PCL and MCL femoral tunnels during a simultaneous reconstruction.
2014
PURPOSE: The purpose of the present study was to assess the risk of femoral tunnel collisions between the medial collateral ligament (MCL) and the posterior cruciate ligament (PCL) tunnels during a simultaneous PCL and MCL reconstruction. METHODS: Fourth generation medium and large synthetic femur bones were used. On each femur, a MCL tunnel and a PCL tunnel were reamed. The MCL tunnel was drilled at 0°, 20° and 40° of axial and coronal angulations. The PCL femoral tunnel was reamed to simulate two different tunnel directions that could be obtained through an inside-out and outside-in technique. Tunnels were filled with epoxy resin augmented with BaSO4, and a multidetector CT examination of…
Tetravalent single-chain avidin: from subunits to protein domains via circularly permuted avidins
2005
scAvd (single-chain avidin, where two dcAvd are joined in a single polypeptide chain), having four biotin-binding domains, was constructed by fusion of topologically modified avidin units. scAvd showed similar biotin binding and thermal stability properties as chicken avidin. The DNA construct encoding scAvd contains four circularly permuted avidin domains, plus short linkers connecting the four domains into a single polypeptide chain. In contrast with wild-type avidin, which contains four identical avidin monomers, scAvd enables each one of the four avidin domains to be independently modified by protein engineering. Therefore the scAvd scaffold can be used to construct spatially and stoich…
Air-kerma evaluation at the maze entrance of HDR brachytherapy facilities.
2014
In the absence of procedures for evaluating the design of brachytherapy (BT) facilities for radiation protection purposes, the methodology used for external beam radiotherapy facilities is often adapted. The purpose of this study is to adapt the NCRP 151 methodology for estimating the air-kerma rate at the door in BT facilities. Such methodology was checked against Monte Carlo (MC) techniques using the code Geant4. Five different facility designs were studied for (192)Ir and (60)Co HDR applications to account for several different bunker layouts.For the estimation of the lead thickness needed at the door, the use of transmission data for the real spectra at the door instead of the ones emit…
The Dark Society
2020
Ulrich Beck, a German sociologist who does not need previous presentation, casts his diagnosis about risk society as a new emerging ethos where social class and hierarchies blurred before the figure of risk. Although he shed light on the post-industrial society of the 90s, today the society he studied seems to be pretty different. Hence, a new fresh insight should replace it. This article introduces readers to the conceptual foundations of Thana Capitalism, as it was critically debated in our book The Rise of Thana Capitalism and Tourism. Per the author's conception, the risk society sets the pace to a new facet of capitalism where the other's pain remains as the main commodity to exchange.…
Ultimate Shear of RC Beams with Corroded Stirrups and Strengthened with FRP
2019
Transverse reinforcement plays a key role in the response behavior of reinforced concrete beams. Therefore, corrosion of steel stirrups may change the failure mode of elements from bending to shear, leading to a brittle and catastrophic crisis. It is important to strengthen reinforced concrete beams with corroded stirrups to enhance the shear resistance. This paper presents a formulation, based on the modified compression field theory, to estimate the ultimate shear of reinforced concrete beams strengthened with FRP, because of stirrup corrosion. The detrimental effect of corrosion on steel stirrup yield strength was taken into account by introducing an empirical decay law. The effective st…
Nonlinear Analysis of Beams Reinforced in Shear with Stirrups and Steel Fibers
2012
The modified compression field theory (MCFT) and the disturbed stress field model (DSFM) are often used to predict the nonlinear behavior of reinforced concrete structures. This study presents several extensions of the MCFT and DSFM to the case of high-strength steel fiber-reinforced concrete beams subjected to transverse loads. Experimental four-point bending tests were conducted on 12 concrete beams with a different percentage of fibers and/or stirrups. To validate the updates introduced in the analytical models, numerical analysis was performed using nonlinear finite element software. Modeling of the post-peak softening branch of the tensile and compressive constitutive curves of fibrous…
Attendibilità dei modelli per la valutazione dei moduli elastici delle murature suggeriti dalle norme tecniche
2012
In this paper the results of an experimental investigation aimed to the assessment of Young moduli, rigidity moduli and other mechanical properties for different types of masonry are shown. The mechanical characteristics predicted by models proposed by some technical codes were compared against experimental data. This study was motivated by the suggestion of the Masonry Standards Joint Committee's (MSJC) code that, while proposing the use of such models, acknowledges the lack of testing in support of their validation. The experimental investigation has included compressive tests on components (blocks and mortar), diagonal compressive tests and ordinary compressive tests (orthogonally to bed…
Physical modeling of heat and moisture transfer in wet bio-sourced insulating materials.
2018
Simultaneous heat and moisture transfers in bio-sourced insulating materials are significant phenomena in thermal metrology. The present study focuses on these phenomena by experimental and numerical approaches based on the asymmetric hot-plate method. In this paper, a bio-sourced insulating material based on flax fibers is developed. The thermal and hygric properties of the sample are then investigated in the humid atmosphere. The temperature is maintained at 30 °C, and the relative humidity varies between 30% and 90% RH. A physics-based model of simultaneous heat and moisture transfer is developed for thermal conductivity estimation. This model is discretized with finite difference method…
Calculation of bone graft volume using 3D reconstruction system.
2010
Objectives: To obtain bone ?bioreplicas? for determining precisely the amount of biomaterial required for bone regeneration procedure. Study design: A case-control comparison with a total sample size of 20 cases, 10 control and 10 test samples. ?Bioreplicas? were generated from helical CAT scans with 0.5 mm slices, without 3D reconstruction or image filters. Bone defects in premolar and molar areas were treated with titanium mesh and xenograft (MP3) combined with resorbable carriers. Time taken to carry out procedures with and without the use of ?bioreplicas? (in minutes), discrepancies between the grafts performed with and without ?bioreplicas? and bone defects (mm), and postoperative comp…
A bicistronic vector backbone for rapid seamless cloning and chimerization of αβT-cell receptor sequences.
2020
To facilitate preclinical testing of T-cell receptors (TCRs) derived from tumor-reactive T-cell clones it is necessary to develop convenient and rapid cloning strategies for the generation of TCR expression constructs. Herein, we describe a pDONR™221 vector backbone allowing to generate Gateway™ compatible entry clones encoding optimized bicistronic αβTCR constructs. It harbors P2A-linked TCR constant regions and head-to-head-oriented recognition sites of the Type IIS restriction enzymes BsmBI and BsaI for seamless cloning of the TCRα and TCRβ V(D)J regions, respectively. Additional well-established TCR optimizations were incorporated to enhance TCR functionality. This included replacing of…