Search results for "cop"
showing 10 items of 25502 documents
Co-crystals of an agrochemical active – A pyridine-amine synthon for a thioamide group
2011
Five novel co-crystals of thiophanate-ethyl (TE), an agrochemical active, with di(2-pyridyl)ketone (1), 2-benzoylpyridine (2), 3-benzoylpyridine (3), 4-phenylpyridine (4) and biphenyl (5) were found and crystal structures of four of them (TE1–TE3, TE5) solved by single crystal X-ray diffraction. Three of the co-crystals (TE1–TE3) form by way of a reliable pyridine-amine hydrogen bond synthon and one (TE5) because of close packing effects. The fifth co-crystal was identified by X-ray powder diffraction. The work demonstrates the usage of a reliable supramolecular synthon for crystal engineering, while concurrently reminds that the close packing of even very similar molecules cannot be fully …
MbCo in Saccharide Solid Amorphous Systems: A Combined FTIR and SAXS Study
2011
Saccharides, and in particular trehalose, are known for their efficiency in protecting biostructures against environmental stress [1], although the preservation mechanism is still debated. Experiments and simulations [2,3] on carboxy-myoglobin (MbCO) showed that the protein dynamics is highly inhibited in dry trehalose matrices, the inhibition being dependent on the water content. In these conditions, a mutual protein-matrix structural and dynamic influence is observed.Here we report a combined FTIR and SAXS study on MbCO embedded in dry amorphous matrices of trehalose and sucrose. FTIR measurements were performed at different protein/sugar ratios, focussing on the stretching band of the bo…
Hydrogen bond properties of saccharide matrices studied through Infrared Water Association Band
2010
Hydrogen bond properties of saccharide matrices studied through Infrared Water Association Band
Role of Solvent on Protein-Matrix Coupling in MbCO Embedded in Water-Saccharide Systems: an FTIR study.
2006
Embedding protein in sugar systems of low water content enables one to investigate the protein dynamicstructure function in matrixes whose rigidity is modulated by varying the content of residual water. Accordingly, studying the dynamics and structure thermal evolution of a protein in sugar systems of different hydration constitutes a tool for disentangling solvent rigidity from temperature effects. Furthermore, studies performed using different sugars may give information on how the detailed composition of the surrounding solvent affects the internal protein dynamics and structural evolution. In this work, we compare Fourier transform infrared spectroscopy measurements (300–20 K) on MbCO e…
Sarcopenia: Research and Clinical Implications
2021
This book offers a concise and updated guide for all readers (physicians and non-physicians) interested in gaining a comprehensive and precise understanding of sarcopenia. Over the last several years, sarcopenia has increasingly developed from being a concept known only in research settings to one that is commonly explored in journals and scientific meetings for various disciplines, such as geriatrics, rheumatology and rehabilitation medicine. Thus, all domains of sarcopenia, from molecular aspects to clinical management, represent highly active areas of research and clinical practice for health professionals in a variety of fields, including geriatric medicine, nutrition, and epidemiology.…
Efectos de un programa de fuerza de alta intensidad de 6 meses de duración sobre parámetros funcionales, clínicos y biomarcadores de imagen en mujere…
2022
Introducción: La sarcopenia se caracteriza por la pérdida de masa, fuerza y funcionalidad de la musculatura en los adultos mayores. La realización de ejercicio físico, y en concreto, el entrenamiento de fuerza, se recomienda para la prevención y manejo de la sarcopenia, pero se desconoce si comporta un beneficio a nivel de calidad y cantidad de la masa muscular según parámetros de imagen por resonancia magnética (IRM). Actualmente, el diagnóstico de sarcopenia está limitado por la falta de consenso en su definición y la heterogeneidad de herramientas que se usan en su análisis. Los criterios diagnósticos deberían incluir, además de una evaluación clínica, unos marcadores objetivos con el fi…
Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by
2019
Total serum magnesium is a common clinical measurement for assessing magnesium status; however, magnesium in blood represents less than 1% of the body’s total magnesium content. We measured intramuscular ionized magnesium by phosphorus magnetic resonance spectroscopy (31P-MRS) and tested the hypothesis that this measure better correlates with skeletal muscle function and captures more closely the effect of aging than the traditional measure of total serum magnesium. Data were collected from 441 participants (age 24–98 years) in the Baltimore Longitudinal Study of Aging (BLSA), a study of normative aging that encompasses a broad age range. Results showed that intramuscular ionized magnesium …
Diagnóstico de sarcopenia y medición de la composición corporal en pacientes con cáncer mediante tomografía computarizada
2020
Los pacientes con cáncer presentan desnutrición asociada no sólo con las características propias del tumor, sino también a los tratamientos que deben ser aplicados para la curación de la enfermedad (cirugía, quimioterapia o radioterapia). El cáncer tiene un efecto negativo sobre la composición corporal, ya que disminuye directamente la ingesta de alimentos del paciente (interfiere mecánicamente con el tránsito del aparato digestivo), o indirectamente (a través de la secreción de sustancias que actúan sobre los receptores periféricos o el hipotálamo). Asimismo, los diferentes tipos de tratamientos aplicados en pacientes con cáncer son una causa importante de la alteración de su estado nutric…
Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women
2020
In midlife, women experience hormonal changes due to menopausal transition. A decrease especially in estradiol has been hypothesized to cause loss of muscle mass. This study investigated the effect of menopausal transition on changes in lean and muscle mass, from the total body to the muscle fiber level, among 47–55-year-old women. Data were used from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, where 234 women were followed from perimenopause to early postmenopause. Hormone levels (estradiol and follicle stimulating hormone), total and regional body composition (dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) scans), physical activity level (self-reported…
Estudio de la sarcopenia y la fragilidad en una población diabética de edad avanzada y su relación con parámetros de estrés oxidativo
2022
El envejecimiento de la población ha provocado que enfermedades crónicas asociadas a la edad como la diabetes mellitus tipo 2 (DM2) y síndromes geriátricos como la fragilidad o la sarcopenia hayan aumentado su prevalencia en la población. La DM2 aumenta el riesgo de padecer sarcopenia y fragilidad en la población geriátrica a la vez que el diagnóstico de sarcopenia y fragilidad supone un factor de riesgo para el desarrollo de diabetes. Al estudiar los mecanismos fisiopatológicos de estas patologías se encuentra el estrés oxidativo (EO) como unión, que podría explicar parte de las consecuencias clínicas asociadas tanto a la fragilidad y sarcopenia como a la DM2. Nuestro objetivo fue estudiar…