Search results for "copd"

showing 10 items of 483 documents

HOPS slimnieku informētība par HOPS medikamentozo aprūpi un tās ārstēšanai izmantojamo zāļu aprite A aptieka - 6

2015

Saslimstība ar HOPS plaši izplatīta pasaulē un kā nāves cēlonis tā ieņem 4. vietu pasaulē vecuma grupā pēc 45 gadiem. HOPS slimībai ir tendence pieaugt. Hroniskais iekaisums rada pastiprinātu elpceļu reaktivitāti, kas izraisa epizodiskas sēkšanas, klepus lēkmes, elpas trūkumu un smaguma sajūtu krūtīs. Lai veiksmīgi ārstētu HOPS slimniekus, būtiska ir pacienta izpratne par saslimšanu un pielietojamo medikamentozo terapiju. Maģistra darba mērķis – bija noskaidrot slimnieku izpratni par HOPS un tās ārstēšanai izmantojamiem medikamentiem un analizet zāļu aprites A aptieka – 6. Pētījumā iegūti rezultāti, ka slimnieku izpratne par HOPS un tās ārstēšanai izmantojamiem medikamentiem ir nepietiekama…

HOPSzāļu apritepatient interviewCOPDFarmācijapacientu aptauja
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Smoking cessation opportunities in severe mental illness (tobacco intensive motivational and estimate risk — TIMER—): study protocol for a randomized…

2019

There is an increased risk of premature death in people with severe mental illness (SMI). Respiratory disorders and cardiovascular disease are leading causes of increased mortality rates in these patients, and tobacco consumption remains the most preventable risk factor involved. Developing new tools to motivate patients towards cessation of smoking is a high priority. Information on the motivational value of giving the lung age and prevention opportunities is unknown in this high-risk population. In the context of community care, screening and early detection of lung damage could potentially be used, together with mobile technology, in order to produce a prevention message, which may provi…

Health Knowledge Attitudes PracticeBipolar DisorderTime FactorsWireless technology:Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings]medicine.medical_treatmentHealth Behavior:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Affective Disorders Psychotic::Bipolar Disorder [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Smoking [Medical Subject Headings]Medicine (miscellaneous)EsquizofreniaSmoking PreventionSeverity of Illness Indexlaw.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Tecnología inalámbricaStudy ProtocolPulmonary Disease Chronic Obstructive0302 clinical medicineRandomized controlled triallawEnfermedad pulmonar obstructiva crónicaMulticenter Studies as TopicPharmacology (medical)Prospective Studies030212 general & internal medicineProspective cohort studyLungRandomized Controlled Trials as Topic:Psychiatry and Psychology::Behavioral Disciplines and Activities::Schizophrenic Psychology [Medical Subject Headings]lcsh:R5-920:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]COPDeducation.field_of_study:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Health Behavior [Medical Subject Headings]Chronic obstructive pulmonary diseaseSmokingTrastorno bipolar:Anthropology Education Sociology and Social Phenomena::Education::Education Nonprofessional::Health Education::Patient Education as Topic [Medical Subject Headings]Cese del uso del tabacoTobacco cessation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Patient Acuity::Severity of Illness Index [Medical Subject Headings]Treatment OutcomeScreeningSchizophrenic Psychologylcsh:Medicine (General)medicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]Bipolar disorderPopulationContext (language use)03 medical and health sciencesPatient Education as Topic:Information Science::Information Science::Communications Media::Telecommunications::Telephone::Cellular Phone::Text Messaging [Medical Subject Headings]Mobile technologySeverity of illness:Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia [Medical Subject Headings]medicine:Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases Obstructive::Pulmonary Disease Chronic Obstructive [Medical Subject Headings]HumansRisk factoreducation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]MotivationText Messagingbusiness.industry:Anatomy::Respiratory System::Lung [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation [Medical Subject Headings]medicine.disease:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Multicenter Studies as Topic [Medical Subject Headings]SpainEmergency medicineSchizophreniaSmoking cessation:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Tobacco Use Cessation::Smoking Cessation [Medical Subject Headings]Smoking Cessationbusiness030217 neurology & neurosurgeryTrials
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MUC1-CT mediates corticosteroid responses in COPD

2016

Background: Corticosteroid resistance is an acquired condition in chronic obstructive pulmonary disease (COPD) patients and a challenge to develop new anti-inflammatory therapies. In previous reports we showed that cytoplasmic tail of the membrain tethered mucin 1 (MUC1-CT) interacts with glucocorticoid receptor (GR) mediating corticosteroid anti-inflammatory efficacy. Objectives: To analyze the role of MUC1-CT as a key marker of corticosteroid efficacy in COPD Methods: The expression of MUC1-CT and the anti-inflammatory role of dexamethasone were evaluated in neutrophils and bronchial epithelial cells from healthy and COPD patients. Anti-inflammatory effects of dexamethasone and glucocorti…

Hormone response elementmedicine.medical_specialtyCOPDbusiness.industrymedicine.drug_classMucinColocalizationmedicine.diseasedigestive systembiological factorsdigestive system diseasesGlucocorticoid receptorEndocrinologyInternal medicineMedicineCorticosteroidskin and connective tissue diseasesbusinessneoplasmsMUC1Dexamethasonemedicine.drug5.1 Airway Pharmacology and Treatment
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Novel in vitro and in vivo data on the cellular localization of Hsp10 in smokers affected by COPD and in lung-derived cell lines exposed to cigarette…

2013

Cigarette smoke is a potent stressor for the respiratory system, contributing to pathogenesis, for instance in chronic obstructive pulmonary disease (COPD), but its effects on the expression, function, and cellular localization of mitochondrial chaperonins are still largely unknown. We studied in vivo (airways biopsies) the localization of Hsp10 and Hsp60 in patients (smokers and non-smokers) affected by mild-moderate COPD, and characterized the effects of non-lethal doses of cigarette smoke extract (CSE) on the expression of these molecules in two human cell lines: lung fibroblasts (HFL-1) and bronchial epithelial (16HBE). We applied various in vitro methods: immunohistochemistry (IHC), su…

Hsp10 copd immunosystem
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IL-17A induces chromatin remodeling promoting IL-8 and TSLP release in bronchial epithelial cells. Effect of Tiotropium.

IL-17A COPD IL-8 chromatin remodeling
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Innate Immunity Responses Are Differently Altered in Central and Distal Airways of COPD Patients.

2009

Innate immune systemCopd patientsbusiness.industryImmunologyMedicinebusinessC31. MECHANISMS OF INFLAMMATION IN THE AIRWAY
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Deep semantic lung segmentation for tracking potential pulmonary perfusion biomarkers in chronic obstructive pulmonary disease (COPD): The multi‐ethn…

2019

Background Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and mortality. Identification of imaging biomarkers for phenotyping is necessary for future treatment and therapy monitoring. However, translation of visual analytic pipelines into clinics or their use in large-scale studies is significantly slowed by time-consuming postprocessing steps. Purpose To implement an automated tool chain for regional quantification of pulmonary microvascular blood flow in order to reduce analysis time and user variability. Study type Prospective. Population In all, 90 MRI scans of 63 patients, of which 31 had a COPD with a mean Global Initiative for Chronic Obstructive Lung …

Intraclass correlationConcordancePopulation030218 nuclear medicine & medical imagingPulmonary Disease Chronic Obstructive03 medical and health sciences0302 clinical medicinemedicineHumansRadiology Nuclear Medicine and imagingProspective StudieseducationLungCOPDeducation.field_of_studyLungmedicine.diagnostic_testbusiness.industryBlood flowAtherosclerosismedicine.diseaseMagnetic Resonance ImagingObstructive lung diseaseSemanticsPerfusionmedicine.anatomical_structureAngiographybusinessNuclear medicineBiomarkersJournal of Magnetic Resonance Imaging
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Cigarette smoke affects the onco-suppressor DAB2IP expression in bronchial epithelial cells of COPD patients

2019

AbstractCigarette smoke is a risk factor for COPD and lung cancer. In cancer, epigenetic modifications affect the expression of Enhancer of Zester Homolog 2 (EZH2), and silenced disabled homolog 2 interacting protein gene (DAB2IP) (onco-suppressor gene) by Histone H3 tri-methylation in lysine 27 (H3K27me3). In“ex vivo”studies, we assessed EZH2, H3K27me3 and DAB2IP immunoreactivity in bronchial epithelial cells from COPD patients (smokers, ex-smokers), Smoker and control subjects. In“in vitro” experiments we studied the effect of cigarette smoke extract (CSE) on EZH2/H3K27me3/DAB2IP expression, apoptosis, invasiveness, and vimentin expression in 16HBE, primary cells, and lung cancer cell lin…

Jumonji Domain-Containing Histone DemethylasesLung NeoplasmsCigar SmokingCelllcsh:MedicineApoptosismacromolecular substancesArticlePulmonary Disease Chronic ObstructiveRisk FactorsmedicineHumansEnhancer of Zeste Homolog 2 ProteinNeoplasm Invasivenesslcsh:ScienceLung cancerA549 CellOncogenesisInflammationA549 cellRegulation of gene expressionCOPDMultidisciplinarybusiness.industrylcsh:REZH2ApoptosiJumonji Domain-Containing Histone DemethylaseCancerras GTPase-Activating Proteinmedicine.diseaseAlveolar Epithelial Cellrespiratory tract diseasesLung NeoplasmGene Expression Regulation NeoplasticNeoplasm Invasiveness Pulmonary Disease Chronic Obstructivemedicine.anatomical_structureA549 Cellsras GTPase-Activating ProteinsApoptosisAlveolar Epithelial CellsCancer researchlcsh:QbusinessHumanairway disease
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Telomere Length in Circulating Leukocytes is Associated with Lung Function and Disease

2014

Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and s…

Lung DiseasesMalePulmonary and Respiratory MedicineSpirometryNetherlands Twin Register (NTR)Vital capacityVital Capacityennenaikainen vanheneminenDiseaseCohort StudiesPathogenesisPulmonary Disease Chronic ObstructiveTelomere HomeostasisSDG 3 - Good Health and Well-beingForced Expiratory VolumeastmaLeukocytes/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansCOPDMedicinekeuhkoahtaumatautiAgedAsthmatelomeeriCOPDmedicine.diagnostic_testpremature agingbusiness.industrySmokingCase-control studyta3141Middle AgedTelomerespirometriamedicine.diseaseAsthmabiologinen ikäbiological age3. Good healthrespiratory tract diseasesEuropeSpirometryCase-Control StudiesImmunologyRegression Analysis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalebusinessEuropean Respiratory Journal
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When kidneys and lungs suffer together

2018

A significant interaction between kidneys and lungs has been shown in physiological and pathological conditions. The two organs can both be targets of the same systemic disease (eg., some vasculitides). Moreover, loss of normal function of either of them can induce direct and indirect dysregulation of the other one. Subjects suffering from COPD may have systemic inflammation, hypoxemia, endothelial dysfunction, increased sympathetic activation and increased aortic stiffness. As well as the exposure to nicotine, all the foresaid factors can induce a microvascular damage, albuminuria, and a worsening of renal function. Renal failure in COPD can be unrecognized since elderly and frail patients…

Lung DiseasesNephrologymedicine.medical_specialty030232 urology & nephrologyRenal functionSettore MED/10 - Malattie Dell'Apparato Respiratorio030204 cardiovascular system & hematologyLung injuryPulmonary Disease Chronic Obstructive03 medical and health sciencesMechanical ventilation0302 clinical medicineRenal DialysisInternal medicineAcute lung injuryCOPD; Pulmonary-renal syndrome; Mechanical ventilation; Acute lung injury; Acute kidney injuryHumansCOPDMedicinebusiness.industryAcute kidney injurymedicine.diseaseAcute kidney injuryrespiratory tract diseasesPneumoniaNephrologyPulmonary-renal syndromeAlbuminuriaCardiologyKidney Failure ChronicKidney Diseasesmedicine.symptomRenal compensationbusinessKidney diseaseJournal of Nephrology
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