Search results for "corn"

Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers

2017

In this work a new copolymer of inulin (INU) derivatized with ethylendiamine (EDA) and retinoic acid (RA), named INU-EDA-RA, was synthetized, characterized and employed to produce micelles as carriers for topical administration of corticosteroids for the potential treatment of diseases of posterior eye segment. Spectroscopic analysis confirmed a molar derivatization degree of 11.30 and 4.30% in EDA and RA, respectively. INU-EDA-RA micelles are capable of strong mucoadhesive interactions which result time-independent and stable over time but concentration depending. Moreover micelles are able to encapsulate efficiently from 3 to 13% (w/w) of lipophilic drugs, as dexamethasone, triamcinolone …

Influence of Chemical Enhancers and Iontophoresis on the In Vitro Transdermal Permeation of Propranolol: Evaluation by Dermatopharmacokinetics

2018

[EN] The aims of this study were to assess, in vitro, the possibility of administering propranolol transdermally and to evaluate the usefulness of the dermatopharmacokinetic (DPK) method in assessing the transport of drugs through stratum corneum, using propranolol as a model compound. Four chemical enhancers (decenoic and oleic acid, laurocapram, and R-(+)-limonene) and iontophoresis at two current densities, 0.25 and 0.5 mA/cm(2) were tested. R-(+)-limonene, and iontophoresis at 0.5 mA/cm(2) were proven to be the most efficient in increasing propranolol transdermal flux, both doubled the original propranolol transdermal flux. Iontophoresis was demonstrated to be superior than the chemical…

DSAEK sottile e ultrasottile

2014

A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts

2020

Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in‐house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV…

Migration, Productive Return and Human Capital: Lessons from the new Governmental Policy on Migration in Ecuador

2017

In 2008, the Government of Ecuador initiated a programme for productive return dubbed the Cucayo Fund, aimed at financing small businesses for migrants who were returning to the country. This programme has been a cornerstone in the new governmental policy on migration. In 2015, the IOM considered it an exemplary practice among the instruments enabling the economic and social reinsertion of returning migrants. In this article, based on the mining and analysis of the implementation data from the Cucayo Fund in the three provinces comprising Administrative Region No 7, we specifically examine the incidence of human capital accumulated by the migrants in the success of their ventures. Our resul…

Searching for new paradigms in a globalized world: Business ethics as a management strategy

2008

The process of globalization is an undeniable reality of today's world. Yet, paradoxically, the cornerstone of this phenomenon, economic performance, varies widely across the world whatever indicator (for example, GDP/habitant, competitiveness) we choose to use to compare countries. Increasingly, studies tend to explain this apparently paradoxical situation with reference to the issue of corruption and ethics. In essence, corruption is perceived to be an important impediment to the economic development of a country (or area). Many studies of corruption are focused at the national level. The aim of this conceptual paper is to explore the role of the firm (as opposed to national states or int…

Finnish Case of Basic Education for All – With Quality Learning Outcomes

2014

This article views behind the success of the Finnish basic education in the PISA assessments in the years 2000, 2003, 2006 and 2009. Success is here defined not only as excellent learning outcomes in reading literacy, mathematics and science, but also as a high level of educational equity and equality. The achieved outcomes are attributable to several factors, of which this article addresses especially the basic education reform of 1972-1977 and the university based teacher education leading to a master’s degree. Additional attention is paid to the autonomy of the municipalities (counties), schools and teachers in building and implementing the curricula, on the respect for learning and teac…

Wiper Tools in Turning Finishing of Quenched Steel

2005

In the last years, the research on metal machining has been focused on the development of tools that can support an increment of the cutting parameters instead of the increment of tool life; this strategy is focused to obtain a relevant productivity increment without getting worse the final product quality. The new design of the tool corner radius has allowed preserving the same product quality due to the “wiper effect” generated during the cut. The employ of such re-designed tools can allow substantial productivity improvements and, by employing the same feedrate, it is possible to achieve excellent surface finish and eliminate the grinding operation. With the aim to verify the possibility…

Financing Small Businesses: From Venture Capital to Crowdfunding

2017

Abstract Startups and small businesses are facing many challenges in terms of financing their activities. These types of companies do not have the possibility to access capital market or to make IPO or to borrow money from banks like big, mature or well-known companies (who were at their beginnings startups or small businesses). They have to find different sources for financing their ideas/products/services that are in many cases very risky, hazardous or to ambitious. But, fortunately, the financing alternative for these companies have evolved during the last post crisis years. They have possibility to find some investors that are willing to invest in a non-name company by accessing crowdfu…

P. Cornelii Scipionis Aemiliani Africani Minoris vita, vel eius dispersae potius reliquiae ex multis probatissimorum Authorum scriptis collectae & in…

1549

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