Search results for "coro"
showing 10 items of 3650 documents
Origine e decorso anomalo della coronaria destra in un caso fatale di tromboembolismo polmonare post-operatorio
2007
La rilevanza del tromboembolismo polmonare trova giustificazione nella sua grande incidenza, nei dati sulla mortalità e nella sua brusca modalità di insorgenza, che la rende trattabile durante la fase acuta. L'arma più efficace contro la TEP è la prevenzione e a tal fine sono state proposte numerose linee guida. Scopo del presente lavoro è illustrare un evento tromboembolico polmonare fatale determinatosi nonostante la somministrazione di una tromboprofilassi aderente alle più accreditate linee guida emanate sull'argomento. La particolare origine anomala della coronaria destra del soggetto, non nota in vita, ha certamente favorito il decesso. Gli Autori pertanto illustrano il ruolo causale …
Intensification of coronary artery arteriosclerosis risk factors occurrence in patients with type A and type B personality features qualified for cor…
2018
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
2020
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
More nature in the city
2020
According to projects and practices that the Italian botanists and ecologists are carrying out for bringing “more nature in the city”, new insights for a factual integration between ecological perspectives and more consolidated aesthetic and agronomic approaches to the sustainable planning and management of urban green areas are provided.
Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein
2003
ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
SARS-CoV-2 envelope protein topology in eukaryotic membranes
2020
Coronavirus E protein is a small membrane protein found in the virus envelope. Different coronavirus E proteins share striking biochemical and functional similarities, but sequence conservation is limited. In this report, we studied the E protein topology from the new SARS-CoV-2 virus both in microsomal membranes and in mammalian cells. Experimental data reveal that E protein is a single-spanning membrane protein with the N-terminus being translocated across the membrane, while the C-terminus is exposed to the cytoplasmic side (Nt lum /Ct cyt ). The defined membrane protein topology of SARS-CoV-2 E protein may provide a useful framework to understand its interaction with other viral and ho…
TikTok w kontekście wspólnoty - relacje i reakcje użytkowników aplikacji w czasie pandemii
2021
Artykuł stanowi próbę wyjaśnienia globalnej popularności aplikacji TikTok, którą zdobyła w bardzo krótkim czasie. Tekst prezentuje również analizę wybranych nagrań dotyczących problematyki koronawirusa, które pojawiły się i zyskały zainteresowanie użytkowników w czasie pandemii. Intencją prowadzonych badań było sprawdzenie, w jaki sposób członkowie TikToka reagują na zagrożenie zdrowia i życia związane z chorobą COVID-19 oraz jak odnajdują się w nowej sytuacji społecznej, która wytworzyła się w obliczu trwającego stanu epidemicznego. Analizy zmierzały zatem również do określenia roli, jaką omawiana aplikacja pełni w czasie pandemii. W tekście zostało poruszone także zagadnienie wspólnoty. W…
L’estètica emocional de la transformació: una revisitació barroca de la Faula d’Apol·lo i Dafne
2021
The well-known Sonnet XIII by Garcilaso de la Vega «A Dafne ya los brazos le crecían» was to establish the disconsolate figure of Apollo, pining for the loss of Daphne, as the literary paradigm of the pangs of love —at least in Renaissance literature in the Iberian peninsula. Thus, a century later, Francesc Fontanella revisited the Garcilaso sonnet and carried out a profoundly Baroque re-reading. The Catalan text ‘transforms’ the symmetry and order in which the Spanish sonnet describes the metamorphosis of the nymph into an inseparable amalgam between the old way of being and the new reality, between the human and the plant, and freezes the figure in mutation: neither the original form nor …