Search results for "cost"
showing 10 items of 5421 documents
Airway Deposition of Extrafine Inhaled Triple Therapy in Patients with COPD: A Model Approach Based on Functional Respiratory Imaging Computer Simula…
2020
Omar S Usmani,1 Nicola Scichilone,2 Benjamin Mignot,3 Dennis Belmans,3 Cedric Van Holsbeke,3 Jan De Backer,3 Roberta De Maria,4 Erika Cuoghi,4 Eva Topole,4 George Georges4 1Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK; 2PROMISE Department of Medicine, University of Palermo, Palermo, Italy; 3FLUIDDA, Kontich, Belgium; 4Chiesi Farmaceutici, SpA, Parma, ItalyCorrespondence: George GeorgesChiesi USA Inc., 175 Regency Woods Place, Ste. 600, Cary, NC 27518, USATel +1 (919) 678 6611 x1536Email george.georges@chiesi.comIntroduction: There is a clear correlation between small airways dysfunction and poor clinical outcomes in patients with chronic obstructiv…
OP0048 Outcomes in Systemic Lupus Erythematous (SLE) Patients Treated with Belimumab in Clinical Practice Settings: Results from the Observe Study in…
2014
Background Large-scale clinical trials have demonstrated clinical efficacy of belimumab in SLE patients. Objectives This study examined the clinical outcomes associated with belimumab in clinical practice settings in Germany. Methods OBSErve (GSK 117214) is a multi-center retrospective medical chart review study. Twenty-one rheumatologists from Germany treating >10 SLE-patients annually and with at least >5 yrs of practice experience were selected for data reporting. Adult SLE patients meeting the ACR classification criteria who received belimumab (10mg/kg) as part of usual care were identified for chart abstraction. Index date was the date of belimumab initiation. The primary outcome measu…
Stability of a Parenteral Formulation of Betamethasone and Levobupivacaine
2014
Background: The therapeutic management of syndromes presenting simultaneously pain and inflammation often requires the administration of anesthetic and corticosteroid drugs by epidural administration. In this article, we studied a mixture that combines betamethasone and levobupivacaine, which demonstrates prolonged analgesic effects. To our knowledge, the stability of such a mixture in epidural solution has not been examined. Objective: To evaluate the chemical, physical, and microbiological stability of an extemporaneously prepared mixture. Methods: A solution of betamethasone acetate 1 mg/mL, betamethasone phosphate 1 mg/mL, and levobupivacaine hydrochloride 0.83 mg/mL was prepared in sa…
Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year’s experience
2020
Background Numerous biochemical datas support the noxious role of anti-inflammatory drugs on immune response. Those observations are often put forward for unfavorable evolution of odontogenic infection but has never been really proven in clinic. The aim of this study is to try to clarify this role based on the collection of the clinical course of odontogenic infections over a 10-year analysis period. Material and Methods The investigators implemented a prospective observational study. The sample was composed of patients managed between January 2004 and December 2014 for severe odontogenic infection based on three criteria: hospital admission, intravenous antibiotic therapy, tooth extraction…
Effects of Home-Based Physical Exercise on Days at Home and Cost-Effectiveness in Pre-Frail and Frail Persons: Randomized Controlled Trial.
2021
Objectives: Frailty increases the risks of hospitalization, institutionalization, and death. Our objective was to study the effects of home-based physical exercise on the number of days spent at home among pre frail and frail persons, versus usual care. In addition, utilization and costs of health care and social services, cost-effectiveness, and health-related quality-of-life (HRQoL) were explored. Design: Randomized controlled trial, with year-long supervised exercise for 60 minutes twice a week versus usual care. Follow-up for 24 months after randomization. Setting and Participants: A sample of 299 home-dwelling persons in South Karelia, Finland. Main inclusion criteria: >65 years, meeti…
La legislazione regionale siciliana in materi di aiuti pubblici alle imprese dinanzi al controllo della Commissione europea
2000
Il saggio esamina la questione della compatibilità della legislazione regionale siciliana con la politica europea della concorrenza, mettendo in lice le criticità emerse dalle posizioni della Commissione europea
La riforma del mercato del lavoro al vaglio della Corte Costituzionale
2005
il saggio analizza l'impatto della riforma del mercato del lavoro (d.lgs. n. 276/2003) sull'assetto costituzionale in materia di riparto di competenze tra stato e regioni. L'autore si propone di offrire una lettura critica della giurisprudenza costituzionale in materia, individuando gli spazi riservati alla competenza del legislatore regionale e quelli riservati al legislatore statale alla luce della riforma del titolo V della Costituzione
La messa alla prova dopo il dictum della Consulta: indenne ma rivisitata e in attesa di nuove censure
2019
Con la sentenza n. 91 del 2018, la Consulta ha avuto modo di offrire una rivisitazione "ad ampio spettro" dell'istituto della sospensione del procedimento con messa alla prova, affrontandone diversi aspetti fondamentali. La pronuncia - pur esprimendosi in termini di inammissibilità o di infondatezza delle questioni sollevate - può essere considerata un importante spartiacque nell'elaborazione ermeneutica della fattispecie, risolvendo alcuni problemi interpretativi e, al contempo, ponendone in luce di nuovi.
Premessa a Metafisica in Jacques Derrida
2014
al di là dell'interesse per la decostruzione della metafisica, si mostra l'importanza del riesame del concetto di metafisica
Testing the Dispersion of Nanoparticles in a Nanocomposite with an Ultra-Low Fill Content Using a Novel Non-Destructive Evaluation Technique
2022
A non-destructive evaluation (NDE) technique capable of testing the dispersion of nanoparticles in a nanocomposite would be of great use to the industry to check the quality of the products made and to ensure compliance with their specifications. Very few NDE techniques found in the literature can evaluate the level of dispersion of the nanoparticles in the whole nanocomposite. Here, a recently developed NDE technique based on pulsed phase thermography (PPT) in transmission mode was used to assess the particle dispersion in ultra-low, less than 0.05 wt%, Ag enriched polymeric based nanocomposite manufactured with an innovative nano-coating fragmentation technique. The phasegrams obtained wi…