Search results for "cost"

Dal disegno alla misura. Ricostruzione del fronte di palazzo Aiutamicristo a Palermo

2020

I laser scanner e la fotogrammetria SfM hanno scardinato il legame tradizionale fra misura e disegno, fissato negli eidotipi che spesso prefiguravano i disegni di restituzione. Il contributo che segue intende dimostrare, attraverso una esemplificazione su un caso studio, che le tecnologie digitali e il lavoro di indagine su repliche del reale, esaltano, attraverso nuovi modi di interazione fra disegno e misura, la possibilità di indagare l’architettura costruita per decodificarne lo schema, il progetto. Il caso studio prescelto è il fronte principale di palazzo Aiutamicristo, costruito a Palermo a partire dal 1490 su progetto di Matteo Carnilivari. Il prospetto di palazzo Aiutamicristo avrà…

Il principio costituzionale di sussidiarietà. I. Premesse teoriche. Modelli operativi. Esperienza dell'Unione europea

2010

Representation of Stationary Multivariate Gaussian Processes Fractional Differential Approach

2011

In this paper, the fractional spectral moments method (H-FSM) is used to generate stationary Gaussian multivariate processes with assigned power spectral density matrix. To this aim, firstly the N-variate process is expressed as sum of N fully coherent normal random vectors, and then, the representation in terms of HFSM is used.

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

2020

ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…

An Information system design product theory for the abstract class of integrated requirements and delivery management systems

2014

Information and Communications Technology-enabled international sourcing of software-intensive systems and services (eSourcing) is increasingly used as a means of adding value, reducing costs, sharing risks, and achieving strategic aims. To maximally reap the benefits from eSourcing and to mitigate the risks, providers and clients have to be aware of and build capabilities for the eSourcing life-cycle. China is in a position to become a superpower for eSourcing service provisioning, but most Chinese eSourcing service providers are small or medium-sized and typically work for larger intermediaries instead of end-clients, limiting their business and capabilities development. The extant litera…

Spatially dynamic forest management to sustain biodiversity and economic returns.

2014

Production of marketed commodities and protection of biodiversity in natural systems often conflict and thus the continuously expanding human needs for more goods and benefits from global ecosystems urgently calls for strategies to resolve this conflict. In this paper, we addressed what is the potential of a forest landscape to simultaneously produce habitats for species and economic returns, and how the conflict between habitat availability and timber production varies among taxa. Secondly, we aimed at revealing an optimal combination of management regimes that maximizes habitat availability for given levels of economic returns. We used multi-objective optimization tools to analyze data fr…

E-NAUTILUS: A decision support system for complex multiobjective optimization problems based on the NAUTILUS method

2015

Interactive multiobjective optimization methods cannot necessarily be easily used when (industrial) multiobjective optimization problems are involved. There are at least two important factors to be considered with any interactive method: computationally expensive functions and aspects of human behavior. In this paper, we propose a method based on the existing NAUTILUS method and call it the Enhanced NAUTILUS (E-NAUTILUS) method. This method borrows the motivation of NAUTILUS along with the human aspects related to avoiding trading-off and anchoring bias and extends its applicability for computationally expensive multiobjective optimization problems. In the E-NAUTILUS method, a set of Pareto…

Comparing the cost-efficiency of CoAP and HTTP in Web of Things applications

2014

Abstract Constrained Application Protocol (CoAP) has been introduced as a simpler alternative to the Hypertext Transfer Protocol (HTTP) for connecting constrained smart objects to the Web. The adoption of the protocol depends on its relative advantage, and the cost–benefit associated with the use of the protocol is a significant factor affecting a protocol adoption decision. This paper aims at deepening the understanding of the cost–benefits of CoAP and identifies the application scenarios where its use is likely to be economically justifiable. The paper analyzes the costs of using CoAP and HTTP in the Web of Things (WoT) applications, by identifying the components of the total cost of owne…

A Novel Model for Cybersecurity Economics and Analysis

2017

In recent times, major cybersecurity breaches and cyber fraud had huge negative impact on victim organisations. The biggest impact made on major areas of business activities. Majority of organisations facing cybersecurity adversity and advanced threats suffers from huge financial and reputation loss. The current security technologies, policies and processes are providing necessary capabilities and cybersecurity mechanism to solve cyber threats and risks. However, current solutions are not providing required mechanism for decision making on impact of cybersecurity breaches and fraud. In this paper, we are reporting initial findings and proposing conceptual solution. The paper is aiming to pr…

Does innovativeness reduce startup survival rates?

2015

There are two competing hypotheses explaining how innovativeness influences the survival of startups: On the one hand, innovativeness is argued to foster survival-enhancing attributes (e.g., market power and cost efficiency) and capabilities (e.g., absorptive capacity). On the other hand, an innovative startup faces (and bears the associated risks of) liabilities of newness and smallness that exceed those of its non-innovative counterparts. The available empirical literature addressing this theoretical tension mostly supports the former hypothesis; we suggest that this finding is, in part, driven by the common practice of employing an ex post measure that already embodies a degree of succes…