Search results for "coste"

Bone metabolism in children with asthma treated with nebulized flunisolide: a multicenter italian study

1998

Abstract This multicenter, parallel-group, open-label, randomized study was conducted in prepubertal children with mild asthma to investigate the efficacy and influence on bone and collagen turnover of a daily regimen of flunisolide 1200 μg alone (group A, n=14), flunisolide 600 μg in combination with sodium cromoglycate (SCG) 60 mg (group B, n=15), or SCG 60 mg alone (group C, n=15) for 4 months. All medications were administered by means of a jet nebulizer using a mouthpiece. Serum osteocalcin (OC), bone alkaline phosphate (B-ALP), and procollagen type I carboxyterminal propeptide (PICP) were measured as markers of bone formation, and type I collagen telopeptide (ICTP) was measured as a m…

A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice

2021

Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These models should encompass crucial features, including persistence of PTSD-like phenotypes triggered after exposure to a single traumatic event, trauma susceptibility/resilience and predictive validity. Here we propose a novel arousal-based individual screening (AIS) model that recapitulates all these features. The AIS model was designed by coupling the traumatization (24 h restraint) of C57BL/6 J mice with a novel individual screening. This screening consists of z-normalization of post-trauma changes in startle …

Piani strategici e politiche di gestione integrata della fascia costiera in Sicilia

2009

Opere dai depositi in mostra alla Galleria d'Arte Moderna di Palermo: "Il Museo tra storia e costume".

2013

MICELLE POLIMERICHE A BASE DI NUOVI DERIVATI ANFIFILICI DELL’INULINA PER LA SOMMINISTRAZIONE OCULARE TOPICA DI CORTICOSTEROIDI NEL TRATTAMENTO DELLE …

2016

Al giorno d’oggi, la via di somministrazione oftalmica costituisce ancora una sfida per i tecnologi farmaceutici. Si tratta, inoltre, probabilmente di uno degli ambiti che più di ogni altro potrebbe beneficiare dello sviluppo di nuovi Drug Delivery Systems basati sull’utilizzo di nanovettori. Infatti, più del 50% delle patologie oculari maggiormente debilitanti (es. degenerazione maculare legata all’età, retinopatia diabetica ed edema maculare diabetico) ha origine a livello del segmento oculare posteriore. Ad oggi, la terapia intravitreale costituisce il gold standard per garantire il raggiungimento del sito target, ovvero la retina. Tuttavia, la necessità di ricorrere a frequenti somminis…

¿Modelo social europeo de bajo coste?

2008

En este ensayo sostengo que las dificultades de la economía europea para generar suficiente empleo y sostener el bienestar, durante la última década, están dando lugar a políticas orientadas hacia la construcción de un "modelo social de bajo coste", apoyado en la idea de "flexeguridad" y en el desarrollo de los yacimientos de empleo. La política de empleo y la política social aparecen imbricadas a través de la precariedad. Además, sugiero críticamente, que el modelo nórdico de "flexeguridad", propuesto como alternativa por la unión europea, a modo de triangulo mágico que combina la flexibilidad en el empleo, formación continua y la provisión de seguridad pública, no parece muy plausible par…

Precocious puberty in Costello syndrome: case report.

2012

Background: Costello syndrome(CS) is a rare autosomal dominant genetically transmitted disease, with: macrocephaly, coarse face with hypertelorism, epicanthal folds, prominent eyes, short nose, low-set ears, large mouth, short stature and failure to thrive, curly hairs, macro glossy, short neck, hyperkeratosis, hyperpigmentation, papillomata around the anus, mouth and nares, thick and loose skin of the hands and feet, cardiomyopathy, mental retardation, increased neoplastic risk. The majority of patients (80-90%) with CS have de novo heterozygous mutations in the HRAS gene (11p15.5). Sporadic cases with GH deficiency are described, even if GH treatment is non clearly associated to a signifi…

Utilización y conocimiento de la herramientas de medición y su relación con los costes de calidad en las empresas certificadas en la norma ISO 9000 d…

2004

En este trabajo presentamos los resultados, sobre la utilización y conocimiento de las herramientas de medición de los sistemas de gestión de la calidad, obtenidos mediante una encuesta postal a todas las empresas certificadas en la norma ISO 9000 de calidad de la Comunidad Valenciana. Entre loas resultados podemos destacar en bajo índice de conocimiento y de utilización de bastantes de estas herramientas, sobre todo por tratarse de empresas certificadas en la norma ISO 9000 de calidad, por otro lado hemos visto que cuanto mayor es la antigüedad en la certificación mayor es el número de herramientas que conocen y utilizan. Los sectores industriales utilizan y conocen más las herramientas qu…

SISTEMI VERDI E AMBIENTI COSTIERI. Linee guida per un progetto tecnologico appropriato

2014

La progettazione tecnologica per l’edilizia negli ultimi anni è caratterizzata da una ricerca sempre maggiore di eco-efficienza e sostenibilità ambientale. Lo scenario normativo, sia nazionale che internazionale, manifesta la necessità di strumenti normalizzati e condivisi, di protocolli tecnici standardizzati, che garantiscano il controllo e la ripetibilità dei risultati. In quest’ottica lo studio approfondisce le specificità del tetto giardino - norma UNI 11235:2007 “Istruzioni per la progettazione, l’esecuzione, il controllo e la manutenzione di coperture a verde”- e del giardino verticale riconoscendo benefici e criticità che contraddistinguono questa ancora poco normalizzata tecnica di…

Efficacy of once-daily tiotropium Respimat in adults with asthma at GINA Steps 2-5.

2020

Tiotropium Respimat is an efficacious add-on to maintenance treatment in patients with symptomatic asthma. Currently, the Global Initiative for Asthma (GINA) strategy recommends tiotropium for patients at Steps 4–5. To assess the clinical benefits of tiotropium Respimat across asthma severities, GINA Steps 2–5, a post hoc analysis of five double-blind trials (12–48-weeks; patients aged 18–75 years) investigated the effect of tiotropium Respimat, 5 μg or 2.5 μg, versus placebo, on peak forced expiratory volume in 1 s (FEV1) within 3 h post-dose (FEV1(0–3h)) response, and Asthma Control Questionnaire-7 (ACQ-7) responder rate. GINA step grouping was based on patients’ background treatment regi…