Search results for "cover"

Contro l’uso della nullita ` parziale in chiave di conformazione del contratto

2020

.Il saggio analizza la tendenza giurisprudenziale a servirsi della nullita ` parziale ex art. 1419 c.c. per realizzare interventi sul contratto animati dall’obiettivo di ridefinirne il contenuto in funzione di riequilibrio dei relativi termini. Il caso piu ` eclatante registrato di recente e ` rappresentato dalla sentenza a Sezioni unite del 2018 in materia di contratti di assicurazione della responsabilita ` civile con copertura claims made, nella quale si e ` assistito all’abbandono del grimaldello della meritevolezza degli interessi di cui all’art. 1322 c.c. a vantaggio di un uso altamente censurabile della categoria della causa del contratto che sfocia in una declaratoria di nullita ` p…

Hormesis: Decoding Two Sides of the Same Coin

2015

In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how t…

Image classification based on 2D feature motifs

2013

The classification of raw data often involves the problem of selecting the appropriate set of features to represent the input data. In general, various features can be extracted from the input dataset, but only some of them are actually relevant for the classification process. Since relevant features are often unknown in real-world problems, many candidate features are usually introduced. This degrades both the speed and the predictive accuracy of the classifier due to the presence of redundancy in the candidate feature set. In this paper, we study the capability of a special class of motifs previously introduced in the literature, i.e. 2D irredundant motifs, when they are exploited as feat…

Finding Repetitions in Biological Networks: Challenges, Trends, and Applications

2013

Impact of Ageing on Pea Protein Volatile Compounds and Correlation with Odor

2022

Vegetal proteins are of high interest for their many positive aspects, but their ‘beany’ off-flavor is still limiting the consumer’s acceptance. The aim of this work was to investigate the conservation of pea protein isolate (PPI) during time and especially the evolution of their organoleptic quality under two storage conditions. The evolution of the volatile compounds, the odor and the color of a PPI has been investigated during one year of storage. PPI was exposed to two treatments mimicking a lack of control of storage conditions: treatment A with light exposition at ambient temperature (A—Light 20 °C) and treatment B in the dark but with a higher temperature …

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors

2012

Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

2021

© 2021 by the authors.

The acute effects of massage on muscle tone and perceived recovery

2008

Haakana, Piia 2008. The acute effects of massage on muscle tone and perceived recovery. Department of biology of physical activity, University of Jyväskylä. Bachelor’s thesis. 47 pp. The physiological effects of massage have been controversial in previous studies. There is one previous study on effects of massage on muscle tone but there were no effects during one month intervention. The purpose of this study was to determine the correlations between subcutaneous tissue and rectus femoris muscle thickness and muscle tone. The differences on muscle tone between groups that received massage immediately or one day after the resistance training were examined. The effects of massage on perceived…

Plant Specialized Metabolites in Hazelnut (Corylus avellana) Kernel and Byproducts: An Update on Chemistry, Biological Activity, and Analytical Aspec…

2019

Abstract Corylus avellana (hazelnut) is one of the most popular tree nuts on a worldwide basis. The main products of C. avellana are kernels, a nutritious food, with a high content of healthy lipids, contained in a hard shell. In recent years, along with the ongoing research carried out on hazelnut kernels, a growing interest has been addressed to the hazelnut byproducts including hazelnut skin, hazelnut hard shell, and hazelnut green leafy cover as well as hazelnut tree leaf. These byproducts deriving from the roasting, cracking, shelling/hulling, and harvesting processes have been found as a source of “phytochemicals” with biological activity. The aim of this review is to provide a compre…

Subjective stress, objective heart rate variability-based stress, and recovery on workdays among overweight and psychologically distressed individual…

2015

Background: The present study aimed to investigate how subjective self-reported stress is associated with objective heart rate variability (HRV)-based stress and recovery on workdays. Another aim was to investigate how physical activity (PA), body composition, and age are associated with subjective stress, objective stress, and recovery. Methods: Working-age participants (n = 221; 185 women, 36 men) in this cross-sectional study were overweight (body mass index, 25.3-40.1 kg/m(2)) and psychologically distressed (>= 3/12 points on the General Health Questionnaire). Objective stress and recovery were based on HRV recordings over 1-3 workdays. Subjective stress was assessed by the Perceived St…