Search results for "crps"
showing 7 items of 7 documents
The Valencia consensus-based adaptation of the IASP complex regional pain syndrome diagnostic criteria
2021
Refereed/Peer-reviewed The new IASP diagnostic criteria for complex regional pain syndrome (CRPS) (aka “the Budapest Criteria”3; Table 1) have improved the diagnostic specificity for CRPS while maintaining good sensitivity. Internationally, these criteria are now in common use. The IASP CRPS Special Interest Group convened a workshop of CRPS experts in Valencia/Spain in September 2019 to review perceived ambiguities in the diagnostic text and issues identified in applying these criteria in both the research and clinical contexts. After this review, workshop attendees discussed and reached a consensus regarding adaptations to the diagnostic taxonomy text. This process resulted in pragmatic u…
Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome
2010
Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients. Discriminating between diagnostic groups based on presence of signs or symptoms meeting IASP criteria showed high diagnostic sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the Budapest clinical criteria retained the exceptional sensitivity of the IASP criteria…
Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS)
2010
Complex regional pain syndrome (CRPS) is a condition that is characterized by severe pain and exaggerated neurogenic inflammation, which may develop after injury or surgery. Neurogenic inflammation is mediated by neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP) that are released from nociceptors. Genetic factors may play a role in CRPS as was suggested by the occurrence of familial cases and several genetic association studies investigating mainly the human leukocyte antigen (HLA) system. Here we investigated the role of neutral endopeptidase (NEP), a key enzyme in neuropeptide catabolism. NEP dysfunction resulting in reduced inactivation of neuropeptides m…
Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase
2009
The complex regional pain syndrome (CRPS) is characterized by enhanced neurogenic inflammation, mediated by neuropeptides. Neutral endopeptidase (NEP) is a key enzyme in neuropeptide catabolism. We used NEP knock out (ko) mice to investigate whether NEP deficiency leads to increased pain behavior and signs of neurogenic inflammation after soft tissue trauma with and without nerve injury. After chronic constriction injury (CCI) of the right sciatic nerve, NEP ko mice were more sensitive to heat, to mechanical stimuli, and to cold than wild type mice. Tissue injury without nerve injury produced no differences between genotypes. After CCI, NEP ko mice showed increased hind paw edema but lower …
Elaboración de un plan de intervención para habilidades sociales en personas con esquizofrenia: estudio piloto del programa CONECTA
2015
Los programas de entrenamiento en Habilidades Sociales (HHSS) son una modalidad de intervención que forma parte de los programas de rehabilitación psicosocial dirigido a los enfermos mentales graves en los sistemas de atención a la salud mental. Estos programas cuentan con una larga trayectoria de implantación desde que se inició la reforma psiquiátrica y con una literatura científica que los avala como una técnica eficaz en el tratamiento de las personas con esquizofrenia. Estos programas se encuentran en la cartera de servicios de los planes de intervención de numerosos países. En España están integrados dentro de diversos dispositivos asistenciales, destacando su utilización en los Centr…
Dysynchiria is not a common feature of neuropathic pain
2006
Patients with chronic neuropathic pain (non-CRPS) and brush-evoked allodynia watched a reflected image of their corresponding but opposite skin region being brushed in a mirror. Unlike complex regional pain syndrome Type 1, this process did not evoke any sensation at the affected area ('dysynchiria'). We conclude that central nociceptive sensitisation alone is not sufficient to cause dysynchiria in neuropathic pain. The results imply a difference in cortical pain processing between complex regional pain syndrome and other chronic neuropathic pain.
Ketamīna lietošana kompleksā reģionālā sāpju sindroma (CRPS) ārstēšanā
2022
Nosaukums: Ketamīna lietošana kompleksā reģionālā sāpju sindroma (CRPS) ārstēšanā Autors: Serge Alan Johansson Darba vadītāja: Iveta Golubovska, Dr. Med. Anesteziologs, reanimatologs un algologs Priekšvēsture: Kompleksais reģionālais sāpju sindroms (CRPS) ir slikti izprasts stāvoklis, kad cilvēkam ir ilgstošas smagas un neciešamas sāpes. Lai gan lielā daļa CRPS gadījumu ir ievainojumu izraisīti, no tā izrietošās sāpes ir ilgstošas un intensīvas. Mērķi: Šī darba mērķis ir izpētīt ketamīna ietekmi uz CRPS ārstēšanu, salīdzinot Numerisko sāpju skalu (NRS) un Analgēzijas nocicepcijas indeksu (ANI). Materiāli un metodes: Pētījums tika veikts, ievadot nelielu Ketamīna devu 25 mg i.v. un novērtējo…