Search results for "cycle"

Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy

2016

AbstractInactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while protecting normal tissues from the side effects of anti-cancer treatment. In this study, we decided to search for kinases that prevent Wip1-mediated sensitization of cancer cells, thereby interfering with efficacy of genotoxic anti-cancer drugs. To this end, we performed a flow cytometry-based screening in order to identify kinases that regulated the levels of γH2AX, which were used as readout. Another criter…

Magnetic field effects on human body of wireless chargers for E-bikes

2017

For the electric vehicles battery charging, the wireless power transmission is increasingly representing an innovative solution. The inductive power transfer is the standard technology of wireless charging: the energy transfer occurs between two magnetically coupled coils. Although this battery charging system is especially convenient for E-bikes, the physiological effects of the related magnetic fields shall be estimated and taken into account. In this paper, a 200 W prototype of wireless battery charger for E-bikes is proposed and described. Moreover, various measurements of the surrounding magnetic field are carried out to evaluate the actual physiological compatibility of the system.

A regenerative braking system for internal combustion engine vehicles using supercapacitors as energy storage elements - Part 2: Simulation results

2020

Abstract In this two-part work, an electric kinetic energy recovery system (e-KERS) for internal combustion engine vehicle (ICEV) is presented and its performance evaluated through numerical simulations. The KERS proposed is based on the use of a supercapacitor as energy storage, interfaced to a brushless machine through a properly designed power converter. In Part 1, the system is described and analysed, and the mathematical model used for the simulations is presented. For each component of the KERS, the real efficiency and the power or energy limitations are adequately considered. In Part 2, the energetic and economic advantages attainable by the proposed KERS are evaluated using MATLAB S…

A regenerative braking system for internal combustion engine vehicles using supercapacitors as energy storage elements - Part 1: System analysis and …

2020

Abstract In this two-part work, an electric kinetic energy recovery system (e-KERS) for internal combustion engine vehicle (ICEV) is presented, and its performance evaluated through numerical simulations. The KERS proposed is based on the use of a supercapacitor as energy storage, interfaced to a brushless machine through a properly designed power converter. In part 1, the system is described and analysed, and the mathematical model used for the simulations is presented. For each component of the KERS, the real efficiency, and the power or energy limitations are adequately considered. In part 2, the energetic and economic advantages attainable by the proposed KERS are evaluated using MATLAB…

Towards an AMTEC-like device based on non-alkali metal for efficient, safe and reliable direct conversion of thermal to electric power

2018

Alkali Metal ThermoElectric Converters directly convert heat into electric energy and have promising applicability in the field of sustainable and renewable energy. The high theoretical efficiency, close to Carnot's cycle, the lack of moving parts, and the interesting operating temperature range drive the search for new materials able to ensure safe and reliable operation at competitive costs.The present work focuses on the design of a non-alkali metal based cell and on the fabrication of a testing device to validate the design work. The selection of a new operating fluid for the cell improves durability, reliability and safety of the device. Finally, we discuss possible applications to alr…

A COMPARISON BETWEEN COMBUSTION PHASE INDICATORS FOR OPTIMAL SPARK TIMING

2008

The closed-loop control of internal combustion engine spark timing may be accomplished by means of a combustion phase indicator, i.e., a parameter, derived from in-cylinder pressure analysis, whose variation is mainly referable to combustion phase shift and assumes a fixed reference value under optimal spark timing operation. The aim of the present work is a comparison between different combustion phase indicators, focusing on the performance attainable by a feedback spark timing control, which uses the indicator as pilot variable. An extensive experimental investigation has been carried out, verifying the relationship between indicators’ optimal values and the main engine running parameter…

A computational framework for low-cycle fatigue in polycrystalline materials

2021

Abstract A three-dimensional framework for low-cycle fatigue analysis of polycrystalline aggregates is proposed in this work. First, a cohesive law coupling plasticity and damage is developed for modelling cycle-by-cycle degradation of material interfaces up to complete de-cohesion and failure. The law may model both quasi-static degradation under increasing monotonic load and degradation under cyclic loading, through a coupled plasticity-damage model whose activation and flow rules are formulated in a thermodynamically consistent framework. The proposed interface laws have been then implemented and coupled with a multi-region boundary element formulation, with the aim of analysing low-cycl…

Phase Stability of Natural Ni0.75Mg0.22Ca0.03CO3 Gaspeite Mineral at High Pressure and Temperature

2020

[EN] Divalent metal carbonates play an important role in Earth's carbon cycle, but the effect of chemical substitution is still poorly known. In this work, we have studied the structural and vibrational properties of natural mineral gaspeite (Ni0.75Mg0.22Ca0.03CO3) under high pressure and temperature using in situ synchrotron X-ray diffraction and Raman spectroscopy in diamond-anvil cells. These experiments have been complemented by ab initio simulations. Synchrotron high-pressure XRD measurements at room temperature using He as the pressure transmitting medium have shown that the calcite-type structure is stable up to 23.3 GPa. A bulk modulus at zero pressure of B-0 = 105(2) GPa with B-0' …

Defensive Behavior of Honey Bees Toward Ants

1970

Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

2012

PMCID: PMC3494587