Search results for "cycle"
showing 10 items of 3119 documents
An Easy Route Towards Regioselectively Difunctionalized Cyclens and New Cryptands.
2006
Reductive amination of various aldehydes with cyclen represents a very convenient method for the synthesis of a wide range of 1,7-difunctionalized cyclens, as well as new cryptands.
Evaluation of asset replacement strategies considering economic cycles: lessons from the machinery rental business
2015
Contains fulltext : 144492.pdf (Publisher’s version ) (Open Access) In businesses with heavy capital investments, the effective management of assets is crucial, in particular in the fleet rental business where assets are the major source of revenues. One important question in this regard concerns the replacement of used assets and the purchase of new assets. Thus, the objective of this study is to evaluate performance effects of asset replacement strategies. In order to maximise net cash flow of a rental company for construction machinery, a range of scenarios investigating the timing and nature of policies for replacing the fleet are analysed. Simulation findings are then discussed to gene…
Domain Specific Case Tool for ICT-Enabled Service Design
2014
One major problem in service design is the limited availability of information gathered during the development process. In particular, information on end-user requirements is difficult for designers, developers, and maintainers to access. Here, we provide a mechanism that supports the gathering and modeling of various types of information throughout the service and software development life cycle. As various existing tools focus on a particular part of the life cycle, essential information is not available, or it is more difficult to obtain in later stages. The linkage between information collected in the different stages is often lost. The implemented tool support enables the modeling of r…
Mathematical models and stability analysis of three-phase synchronous machines
2013
BaGaTel: an ontology driven database on food composition, transformation process, nutritional, sensory and environmental quality
2019
National audience
Addressing Complexity in Science|Environment|Health Pedagogy
2019
This paper aims to discuss complexity as a key feature for understanding the role of science knowledge in environmental and health contexts—a central issue in Science|Environment|Health pedagogy. Complex systems are, in principle, not predictable. In different contexts, ephemeral mechanisms produce different, sometimes completely unexpected results. The art of decision-making in complex contexts is to take scientific knowledge into account but to interpret its meaning in terms of concrete complex contexts. This is illustrated by four empirical studies on Science|Environment|Health issues, presented midway through this paper. The findings underscore the importance of introducing complexity i…
Process and product in non-narrative writing : a teaching material package for the upper secondary school
1997
Conception de systèmes agroécologiques à l'échelle d'un territoire : un exemple de co-construction d'un projet d'expérimentation
2014
Un workshop a réuni une centaine de personnes à Dijon, chercheurs, acteurs de la profession agricole et pouvoirs publics, autour du thème de la conception de systèmes agricoles agroécologiques à l’échelle d’un territoire. Les journées ont permis de faire le point sur les méthodes expérimentales à cette échelle, et sur les connaissances disponibles en agroécologie pour construire des protocoles expérimentaux.
The Scope of Application of Macrocyclic Polyamines Beyond Metal Chelation
2019
International audience; Recent advances in the use of radiometals for both imaging and therapy has spurred on the development of an original chemistry that endows radionuclide-chelating molecular cages with ever sharper physicochemical properties. Macrocyclic polyamines (MPAs) such as cyclen and DOTA are among the most frequently encountered cages for the design of new radiotracers, owing to their versatile chemistry that makes them customizable molecular tools. The idea of using MPAs for alternative purposes has recently emerged, with an eye towards benefiting from their unique topology, versatility, symmetry and water-solubility. This review summarizes strategies that have been recently i…
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives
2014
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…