Search results for "cycle"
showing 10 items of 3119 documents
7-Azaindole-fused heterocycles with antitumor activity
2011
New Tripentone Analogs with Antiproliferative Activity
2017
Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar range. New tripentone analogs, in which a pyridine moiety replaces the thiophene ring originating the fused azaindole system endowed with anticancer activity viz 8H-thieno[2,3-b]pyrrolizinones, were efficiently synthesized in four steps with fair overall yields (34–57%). All tripentone derivatives were tested in the range of 0.1–100 μM for cytotoxicity against two human tumor cell lines, HCT-116 (human colorectal carcinoma) and MCF-7 (human breast cancer). The most active derivative, with GI50 values of 4.25 µM and 20.73 µM for HCT-116 a…
The intensity contrast of solar photospheric faculae and network elements : II. Evolution over the rising phase of solar cycle 23
2006
We studied the radiative properties of small magnetic elements (active region faculae and the network) during the rising phase of solar cycle 23 from 1996 to 2001, determining their contrasts as a function of heliocentric angle, magnetogram signal, and the solar cycle phase. We combined near-simultaneous full disk images of the line-of-sight magnetic field and photospheric continuum intensity provided by the MDI instrument on board the SOHO spacecraft. Sorting the magnetogram signal into different ranges allowed us to distinguish between the contrast of different magnetic structures. We find that the contrast center-to-limb variation (CLV) of these small magnetic elements is independent of …
PINK1: a critical protein kinase in the molecular mechanisms involved in Cancer and Parkinson's disease
2012
El cáncer y la enfermedad de Parkinson (PD) son dos enfermedades en las que el mecanismo pato- fisiológico final no está completamente definido. Datos epidemiológicos indican que los pacientes con PD poseen bajo riesgo de cáncer, con la excepción de melanoma maligno y cánceres de piel, tiroides y mama, lo que sugiere una conexión funcional entre PD y cáncer. Apoyando esta conexión, la desregulación de la homeostasis mitocondrial es una característica importante en la patogénesis de ambas enfermedades. Recientemente, varios genes asociados a PD, tales como Parkin, LRRK2, DJ-1, y PINK1, han sido propuestos como moduladores de procesos cancerígenos. Mutaciones en el gen de PINK1 están asociada…
A dual channel sulphur-containing a macrocycle functionalised BODIPY probe for the detection of Hg(II) in a mixed aqueous solution
2018
We report herein the synthesis and chromo-fluorogenic behaviour of a new probe 1 containing a boron-dipirromethene (BODIPY) unit electronically connected with a dithia-dioxa-aza macrocycle. Acetonitrile and water-acetonitrile 95:5 v/v solutions of the probe showed an ICT band in the visible zone and are nearly non-emissive. When acetonitrile was used as solvent, addition of Hg(II) and trivalent metal cations induced an hypsochromic shift of the absorption band and moderate emission enhancements. A highly selective response was obtained when using competitive media such as wateracetonitrile 95:5 v/v. In this case only Hg(II) induced a hypsochromic shift of the absorption band and a marked em…
Deep-Sea Bioluminescence Blooms after Dense Water Formation at the Ocean Surface
2013
The deep ocean is the largest and least known ecosystem on Earth. It hosts numerous pelagic organisms, most of which are able to emit light. Here we present a unique data set consisting of a 2.5-year long record of light emission by deep-sea pelagic organisms, measured from December 2007 to June 2010 at the ANTARES underwater neutrino telescope in the deep NW Mediterranean Sea, jointly with synchronous hydrological records. This is the longest continuous time-series of deep-sea bioluminescence ever recorded. Our record reveals several weeks long, seasonal bioluminescence blooms with light intensity up to two orders of magnitude higher than background values, which correlate to changes in th…
Violence against parents: key factors analysis
2014
La Fiscalía General del Estado español, en su memoria de octubre de 2009, destacó que la violencia filio-parental era el tipo penal más preocupante en adolescentes menores de edad por su incremento en prevalencia e incidencia. Por ello, es importante conocer algunas características de las familias que la sufren y de las hijas e hijos maltratadores. Para lograr dichos objetivos hemos realizado una revisión bibliométrica de análisis cualitativo en base a documentos y libros desde 1957 hasta 2011, de países como Australia, Japón, Canadá, Nueva Zelanda, Francia, E.E.U.U. o España principalmente, desde la cual se pretende conocer (a) qué es la violencia filio-parental, (b) el ciclo de este tipo …
Hydrography and food distribution during a tidal cycle above a cold-water coral mound
2022
Cold-water corals (CWCs) are important ecosystem engineers in the deep sea that provide habitat for numerous species and can form large coral mounds. These mounds influence surrounding currents and induce distinct hy- drodynamic features, such as internal waves and episodic downwelling events that accelerate transport of organic matter towards the mounds, supplying the corals with food. To date, research on organic matter distribution at coral mounds has focussed either on seasonal timescales or has provided single point snapshots. Data on food distribution at the timescale of a diurnal tidal cycle is currently limited. Here, we integrate physical, biogeochemical, and biological data throug…