Search results for "cycle"

A Mutually Stimulating Loop Involving Emx2 and Canonical Wnt Signalling Specifically Promotes Expansion of Occipital Cortex and Hippocampus

2005

The correct size of the different areas composing the mature cerebral cortex depends on the proper early allocation of cortical progenitors to their distinctive areal fates, as well as on appropriate subsequent tuning of their area-specific proliferation--differentiation profiles. Whereas much is known about the genetics of the former process, the molecular mechanisms regulating proliferation and differentiation rates within distinctive cortical proto-areas are still largely obscure. Here we show that a mutual stimulating loop, involving Emx2 and canonical Wnt signalling, specifically promotes expansion of the occipito-hippocampal anlage. Collapse of this loop occurring in Emx2 2/2 mutants …

Integrable systems, Frobenius manifolds and cohomological field theories

2022

In this dissertation, we study the underlying geometry of integrable systems, in particular tausymmetric bi-Hamiltonian hierarchies of evolutionary PDEs and differential-difference equations.First, we explore the close connection between the realms of integrable systems and algebraic geometry by giving a new proof of the Witten conjecture, which constructs the string taufunction of the Korteweg-de Vries hierarchy via intersection theory of the moduli spaces of stable curves with marked points. This novel proof is based on the geometry of double ramification cycles, tautological classes whose behavior under pullbacks of the forgetful and gluing maps facilitate the computation of intersection…

Inequalities in Consumption Patterns over the Life Cycle and during the Great Recession

2015

The aim of the study is to analyse the relationship between recession, population structure and consumption behaviour over the life cycle. To this aim, we consider three clusters of non-durable expenditures such as food at home, work-related and core expenditures. The analysis has been performed on micro data on the Household Budgets for the period 1997-2013. Based on life cycle theory, two statistical models has been estimated, viz. a pre-crisis (1997-2007) and a great recession period (2008-2013) model. The study shows that the recession has entailed a reduction of the average expenditure for each category of consumption, and the intensity of the reduction is different among households an…

SyRAF - Synthesised Results and Applicable Findings of CEDR Call 2017 New Materials

2022

Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.

2012

Abstract Tumor-initiating cells are responsible for tumor maintenance and relapse in solid and hematologic cancers. Although tumor-initiating cells were initially believed to be mainly quiescent, rapidly proliferating tumorigenic cells were found in breast cancer. In colon cancer, the proliferative activity of the tumorigenic population has not been defined, although it represents an essential parameter for the development of more effective therapeutic strategies. Here, we show that tumorigenic colon cancer cells can be found in a rapidly proliferating state in vitro and in vivo, both in human tumors and mouse xenografts. Inhibitors of polo-like kinase1 (Plk1), a mitotic kinase essential fo…

Tangential Hilbert problem for perturbations of hyperelliptic Hamiltonian systems

1999

The tangential Hilbert 16th problem is to place an upper bound for the number of isolated ovals of algebraic level curves { H ( x , y ) = const } \{H(x,y)=\operatorname {const}\} over which the integral of a polynomial 1-form P ( x , y ) d x + Q ( x , y ) d y P(x,y)\,dx+Q(x,y)\,dy (the Abelian integral) may vanish, the answer to be given in terms of the degrees n = deg ⁡ H n=\deg H and d = max ( deg ⁡ P , deg ⁡ Q ) d=\max (\deg P,\deg Q) . We describe an algorithm producing this upper bound in the form of a primitive recursive (in fact, elementary) function of n n and d d for the particular case of hyperelliptic polynomials H ( x , y ) = y 2 + U ( x ) H(x,y)=y^2+U(x) under the additional as…

Two groups with isomorphic group algebras

1990

Finite groups with subgroups supersoluble or subnormal

2009

Abstract The aim of this paper is to study the structure of finite groups whose non-subnormal subgroups lie in some subclasses of the class of finite supersoluble groups.

IT-Enabled Effective and Efficient International Technology Transfer for SMEs

1999

This study describes the introduction of a new international technology transfer paradigm. The essence of this new paradigm is based on IT-enabled ITT process. The modern business environment is overwhelmed by increased competition and uncertainty, rapid changes in technology, a diminished technology life cycle, and the advent of more powerful, cheaper and easier to use ITs. These factors reinforce the need for the investigation of globalization possibilities of western SMEs via the utilization of high potential ITs in ITT. The ITT process has become more efficient as new ITs are integrated with SMEs’ existing information systems. This type of integration also eliminates many barriers of di…

On the determination of coherent solar climates over a tropical island with a complex topography

2020

Abstract Many tropical islands aim at developing a greener self-sufficient energy production systems based on renewable energy, notably solar-generated electricity. This work explores the mean diurnal and annual solar cycles over La Reunion island (southwest Indian Ocean: 21°S, 55.5°E), and their spatial behavior, using the Solar surfAce RAdiation Heliosat – East (SARAH-E) satellite-derived data at high spatial ( 0.05 ° × 0.05 ° ) and time (hourly) resolutions over period 1999–2016. Comparisons of the SARAH-E data with ground-based measurements over the period 2011–2015 show differences of ~ 15 % for diurnal-seasonal variations. The solar resource over the island displays strong spatial var…