Search results for "cyclic"

Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed i…

2010

Heterocyclic aromatic amines (HAAs) can be formed during the cooking of meat and fish at elevated temperatures and are associated with an increased risk for cancer. On the other hand, epidemiological findings suggest that foods rich in fruits and vegetables can protect against cancer. In the present study three teas, two wines, and the juices of 15 fruits and 11 vegetables were investigated for their protective effect against the genotoxic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). To closely mimic the enzymatic activation of these HAAs in humans, genetically engineered V79 Chinese hamster fibroblasts were employed tha…

Adsorption of gelatin during electrodeposition of copper and tin-copper alloys from acid sulfate electrolyte

2014

International audience; An acid Cu–Sn deposition bath was developed, and copper and copper–tin coatings were electrodeposited on polycrystalline platinum. The effect of gelatin on copper and copper–tin electrodeposition from acid sulfate solutions has been investigated by a variety of electrochemical methods (voltammetric studies and electrochemical quartz crystal microbalance) as well as by morphologic technique (scanning electron microscopy). The electrochemical results have shown that the overpotential is required when gelatin is added, indicating the presence of interaction between the additive and the coating. From the results of X-ray photoelectron spectroscopy, PM-IRRAS and cyclic vo…

Estimation of sparse generalized linear models: the dglars package

2013

dglars is a public available R package that implements the method proposed in Augugliaro, Mineo and Wit (2013) developed to study the sparse structure of a generalized linear model. This method, called dgLARS, is based on a differential geometrical extension of the least angle regression method (LARS). The core of the dglars package consists of two algorithms implemented in Fortran 90 to efficiently compute the solution curve; specifically a predictor-corrector algorithm and a cyclic coordinate descent algorithm.

Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors.

1999

The assembly of signalling molecules into macromolecular complexes (transducisomes) provides specificity, sensitivity and speed in intracellular signalling pathways. Rod photoreceptors in the eye contain an unusual set of glutamic-acid-rich proteins (GARPs) of unknown function. GARPs exist as two soluble forms, GARP1 and GARP2, and as a large cytoplasmic domain (GARP' part) of the beta-subunit of the cyclic GMP-gated channel. Here we identify GARPs as multivalent proteins that interact with the key players of cGMP signalling, phosphodiesterase and guanylate cyclase, and with a retina-specific ATP-binding cassette transporter (ABCR), through four, short, repetitive sequences. In electron mic…

Visually induced motion sickness and presence in videogames: The role of sound

2012

Visually induced motion sickness (VIMS) is a well-known phenomenon in virtual environments, simulators, and videogames. We conducted an experiment to analyze the role of sound on the severity of VIMS and the feeling of presence in videogames. Thirty-two subjects first watched a pre-recorded sequence of the game “Mirrors Edge” and then played the game actively. Game-play sound was activated for half of the participants. VIMS was measured via the Simulator Sickness Questionnaire and the Fast Motion Sickness Scale, presence was captured using the Presence Questionnaire. Results showed severe VIMS in all participants during the passive video session, whereas active-play revealed only moderate …

Elevated polycyclic aromatic hydrocarbons in a river floodplain soil due to coal mining activities

2007

Elevated PAH concentrations were found in soil samples collected along the Mosel River. These contaminations were associated with the occurrence of coal particles found in the soil. The majority of the PAH contamination in the soils was linked to coal mining activities in the Saar region. Density and grain size separation showed a similar PAH distribution pattern in all of the fractions, indicating a uniform origin of PAHs. Together with coal petrography a good correlation between TOC and PAHs concentration confirmed the impact of former coal mining activity on the PAHs distribution in study area.

Organocatalytic approach to benzofused nitrogen-containing heterocycles: enantioselective total synthesis of (+)-angustureine.

2008

Additional file 8: of A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer pat…

2019

Sequence of primers used by pyrosequencing in the validation assay of candidate genes obtained from 450k array (PPT 143 kb)

Additional file 7: of A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer pat…

2019

Clinical inclusion and exclusion criteria followed to select TNBC patients for the methylation study (PPT 89 kb)

Warfarin Guide: Co-design of a Mobile Computer-Assisted Anticoagulant Therapy

2017

Patients with some types of cardiovascular disease are prescribed anticoagulation therapy with Warfarin in order to control the ability of blood clotting. This work presents a co-designed mobile application, called Warfarin Guide, for a computer-assisted anticoagulant therapy. The application addresses the challenges that unexperienced patients may find when having to remember to regularly check their INR values and make temporary adjustments for INR value fluctuations that are not easy to interpret without direct medical advice. nivå1