Search results for "cyclin"
showing 10 items of 1021 documents
AZ31 magnesium alloy recycling through friction stir extrusion process
2015
Friction Stir Extrusion is a novel technique for direct recycling of metal scrap. In the process, a dedicated tool produces both the heat and the pressure to compact and extrude the original raw material, i.e., machining chip, as a consolidated component. A proper fixture was used to carry out an experimental campaign on Friction Stir Extrusion of AZ31 magnesium alloy. Variable tool rotation and extrusion ratio were considered. Appearance of defects and fractures was related to either too high or too low power input. The extruded rods were investigated both from the metallurgical and mechanical points of view. Tensile strength up to 80 % of the parent material was found for the best combina…
Friction stir extrusion to recycle aluminum alloys scraps: Energy efficiency characterization
2019
Abstract Solid state recycling refers to a group of processes allowing direct recycling of metals scraps into semi-finished product. Their main advantage lies in avoiding the molten state of the material which badly affects the environmental performance of the conventional (remelting based) recycling routes. It is expected that such process category would lower the environmental performance of metals recycling. In this paper, the friction stir extrusion process for aluminum alloy AA 2050 wire production is analyzed under the primary energy demand perspective. The process electrical energy demand is quantified with varying process parameters. An empirical modelling approach was applied and a…
Uncovering Technological and Environmental Potentials of Aluminum Alloy Scraps Recycling Through Friction Stir Consolidation
2020
Conventional metal chips recycling processes are energy-intensive with low efficiency and permanent material losses during re-melting. Solid state recycling allows direct recycling of metal scraps into semi-finished products. It is expected that this process category would lower the environmental performance of metals recycling. Friction Stir Consolidation is a new solid-state technique taking advantage of friction heat generation and severe plastic deformation to consolidate chips into billets. In this research, the feasibility of Friction Stir Consolidation as aluminum chips recycling process is analyzed. Specifically, an experimental campaign has been carried out with varying main proces…
Aluminium sheet metal scrap recycling through friction consolidation
2019
Abstract In the last decades, several direct-recycling techniques have been developed and investigated in order to avoid material remelting, typical of the conventional aluminum alloys recycling processes. Moreover, the remelting step for aluminum recycling is affected by permanent material losses. Solid-state recycling processes have proven to be a suitable strategy to face such issues. Friction Consolidation is an innovative solid state-recycling technology developed for metal chips. During the process, a rotating die is plunged into a hollow chamber containing the material to be processed. The work of friction forces decaying into heat soften the material and, together with the stirring …
An energy efficiency analysis of Single Point Incremental Forming as an Approach for Sheet Metal Based Component Reuse
2020
Abstract Producing materials causes about 25% of all anthropogenic CO2 emissions. Metals play a significant role, steel and aluminum account for 24% and 3% of worldwide material related emissions respectively. Fostering resources efficiency strategies in the field of sheet components could lead to a significant environmental impact reduction. Reshaping could be one of the most efficient strategy to foster material reuse and lower the environmental impact due to material production. Specifically, for aluminum recycling, the overall energy efficiency of conventional route is very low and, more importantly, permanent material losses occur during re-melting because of oxidation. The present pap…
Participation and performance trends in ultra-triathlons from 1985 to 2009
2010
We examined the changes in participation and performance trends in ultra-triathlons, from the Double Iron (7.6 km swimming, 360 km cycling, 84.4 km running) to the Deca Iron (38 km swimming, 1800 km cycling, 422 km running), between 1985 (first year of a Double Iron) and 2009 (25 years). The mean finish rate for all distances and races was 75.8%. Women accounted for ∼8-10% of the ultra-triathlons starters. For Double and Triple Iron, the number of finishers per year increased, from 17 to 98 and from 7 to 41, respectively. In the Deca Iron, the finishers per race have remained <20 since the first event was held, up to 2009. Concerning World best performances, the men were ∼19% faster than th…
Antibiotic treatment of infections caused by carbapenem-resistant Gram-negative bacilli: an international ESCMID cross-sectional survey among infecti…
2018
ESGAP, ESGBIS, ESGIE and the CRGNB treatment survey study group.
Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells.
2021
Adipose stem cells (ASCs) represent a reliable source of stem cells with a widely demonstrated potential in regenerative medicine and tissue engineering applications. New recent insights suggest that three-dimensional (3D) models may closely mimic the native tissue properties; spheroids from adipose derived stem cells (SASCs) exhibit enhanced regenerative abilities compared with those of 2D models. Stem cell therapy success is determined by “cell-quality”; for this reason, the involvement of stress signals and cellular aging need to be further investigated. Here, we performed a comparative analysis of genes connected with stemness, aging, telomeric length and oxidative stress, in 3D and 2D …
The Amount of Melanin Influences p16 Loss in Spitzoid Melanocytic Lesions: Correlation With CDKN2A Status by FISH and MLPA.
2019
AIMS The risk assessment of spitzoid lesions is one of the most difficult challenges in dermatopathology practice. In this regard, the loss of p16 expression and the homozygous deletion of CDKN2A, have been pointed in the literature as reliable indicators of high risk. However, these findings are poorly reproducible, and the molecular bases underlying the loss of p16 expression remain unclear. We aimed to identify the underlying events causing loss of CDKN2A/p16 in spitzoid tumors. MATERIALS AND METHODS We evaluated the immunohistochemical expression of p16, and the presence of CDKN2A genetic alterations detected through fluorescence in situ hybridization (FISH) and multiplex ligation-depen…
SOX2 expression diminishes with ageing in several tissues in mice and humans.
2017
SOX2 (Sex-determining region Y box 2) is a transcription factor expressed in several foetal and adult tissues and its deregulated activity has been linked to chronic diseases associated with ageing. Nevertheless, the level of SOX2 expression in aged individuals at the tissue level has not previously been examined. In this work, we show that SOX2 expression decreases significantly in the brain with ageing, in both humans and rodents. The administration of resveratrol for 6 months in mice partly attenuated this reduction. We also identified an age-related decline in SOX2 mRNA and protein expression in several other organs, namely, the lung, heart, kidney, spleen and liver. Moreover, periphera…