Search results for "d-a"
showing 10 items of 426 documents
PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.
2018
The oral controlled release (CR) formulations have become more important in recent years. Among them, the polymeric nanoparticles have been thoroughly studied during the last decades, consequently they are extensively employed for a broad range of applications and drugs. The objective of this research was to develop polymeric nanoparticles (NPs) of ibuprofen with poly(lactic-co-glycolic) acid (PLGA) as polymer, and to test their applicability for oral CR formulations development. Different proportions of drug/polymer were employed to develop the ibuprofen NPs and their in vitro release profiles were analysed. The in situ segmental permeability of ibuprofen was tested in Wistar rat and demon…
Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol.
2016
Abstract To ensure the optimal performance of oral controlled release formulations, drug colon permeability is one of the critical parameters. Consequently developing this kind of formulations for low permeability molecules requires strategies to increase their ability to cross the colonic membrane. The objective of this work is to show if an ion-pair formation can improve the colon permeability of atenolol as a low permeability drug model. Two counter ions have been tested: brilliant blue and bromophenol blue. The Distribution coefficients at pH 7.00 (DpH7) of atenolol, atenolol + brilliant blue and atenolol + bromophenol blue were experimentally determined in n-octanol. Moreover, the colo…
Solid lipid nanoparticles containing tamoxifen characterization and in vitro antitumoral activity.
2005
Solid lipid nanoparticles (SLNs) containing tamoxifen, a nons- teroidal antiestrogen used in breast cancer therapy, were prepared by microemulsion and precipitation techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration, and in vitro plasmatic drug release studies demon- strated that these systems are able to give a prolonged release of the drug in the intact form. Preliminary study of antiproliferative ac- tivity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. The results of char- acterization studies and of in vitro …
Pharmacology of Acamprosate: An Overview
2003
In the last years important advances have been made in the development of drugs for the treatment of alcohol addiction. Acamprosate (calcium bis‐acetylhomotaurine) is one of the better established drugs in this field on the European market. This review focuses first on the pharmacokinetics of acamprosate. The published data and the recent advances in our knowledge on the mechanisms involved in the intestinal absorption and elimination of this drug are summarized. The importance of pharmacokinetics for the proper clinical use of acamprosate is highlighted. The anti‐relapse as well as the well‐known effects of acamprosate on ethanol intake are discussed. The recent experiments in animal model…
¿SE PUEDE MEDIR LA NEGOCIACIÓN INFORMADA?: UNA REVISIÓN DE LA METODOLOGÍA BASADA EN LAS COVARIANZAS DE LAS SERIES DE PRECIOS
2009
RESUMENEl desarrollo en los modelos teóricos de microestructura ha motivado la aparición de un grupo de trabajos encaminado al estudio empírico de los costes de transacción y sus componentes dada la importancia que han tenido los mismos en el estudio del funcionamiento de los mercados y la comparación entre éstos así como sus numerosas aplicaciones en campos afines (finanzas corporativas, eficiencia de los mercados, etc.). Por otra parte, la contrastación empírica de los distintos modelos establecidos muestra resultados claramente dispares. Por ello, el objetivo de nuestro trabajo es analizar con detalle y en conjunto dichos modelos centrándonos en un grupo con características muy similares…
Los documentales científicos como instrumentos de educación para la sostenibilidad
2010
El objeto de este trabajo se centra en analizar el papel que están jugando y pueden llegar a jugar los documentales científicos que se difunden ampliamente a través de la TV, venta en quioscos, etc., en la formación de una ciudadanía consciente de los problemas a los que se enfrenta hoy la humanidad y preparada para participar en la adopción de las medidas necesarias
Modulation of Neurological Deficits and Expression of Glutamate Receptors during Experimental Autoimmune Encephalomyelitis after Treatment with Selec…
2013
The aim of our investigation was to characterize the role of group I mGluRs and NMDA receptors in pathomechanisms of experimental autoimmune encephalomyelitis (EAE), the rodent model of MS. We tested the effects of LY 367385 (S-2-methyl-4-carboxyphenylglycine, a competitive antagonist of mGluR1), MPEP (2-methyl-6-(phenylethynyl)-pyridine, an antagonist of mGluR5), and the uncompetitive NMDA receptor antagonists amantadine and memantine on modulation of neurological deficits observed in rats with EAE. The neurological symptoms of EAE started at 10-11 days post-injection (d.p.i.) and peaked after 12-13 d.p.i. The protein levels of mGluRs and NMDA did not increase in early phases of EAE (4 d.p…
Technical-economical evaluation for distributed storage applications. An Italian case study for a medium-scale public facility
2014
Time-of-use energy cost management involves the use of storage by customers to reduce their electricity bills. This can be accomplished by charging the storage during off-peak time periods, when electricity energy prices are low, and discharging it during times when on-peak energy prices are applied. This article addresses the question whether it is economically viable to install medium-scale distributed storage devices in the power system designed to lower the electricity cost for a customer-side application, assuming flexible electricity tariffs. The technical/economical evaluation is carried out referring to Lithium ion (Li-ion), Sodium Sulphur (NaS) and Vanadium Redox Battery (VRB) tech…
Control and power management of Photovoltaic-battery based micro grid
2016
The growing demand for electrical power and the interruption of the power supply has paved the way for the realization of renewable based energy generation. This paper presents the control and power management of a hybrid microgrid system that comprises Photovoltaic (PV) array, battery, and local AC load, connected to the utility grid. This work focuses on the compensation of PV power reduction due to partial shading using bidirectional half bridge converter with battery storage. This system considers fulfilling the local load demand through PV production and, then, to manage the power among the battery and grid. In the proposed system, the considered power conditioning devices area boost c…
Reliability Analysis of a Stand-Alone PV System for the Supply of a Remote Electric Load
2010
The work presents a reliability analysis of a stand-alone photovoltaic system for the supply of electric loads located in remote areas not easily reachable by the low voltage distribution network. The analysis is performed by characterizing the electric load behavior by means of a Montecarlo approach for taking into account the stochastic variability of the electrical energy demand. A Montecarlo approach is used also for evaluating the electricity production of the stand alone photovoltaic system as a function of the hourly solar irradiation of the installation site. The variability both of the load and of the energy production are correlated and the probability that the load can remain uns…