Search results for "d-a"
showing 10 items of 426 documents
Efficacy and safety of indacaterol and tiotropium in COPD patients according to dyspnoea severity.
2013
Background Guidelines for chronic obstructive pulmonary disease (COPD) recommend that treatment choices be based partly on symptoms. Methods A post-hoc analysis of pooled data from clinical studies compared the efficacy and safety of once-daily inhaled bronchodilators indacaterol (150 and 300 μg) and open-label tiotropium (18 μg) according to baseline dyspnoea severity on the modified Medical Research Council (mMRC) scale in patients with COPD (mMRC scores <2 = ‘less dyspnoea’; scores ≥2 = ‘more dyspnoea’). Outcomes were assessed after 26 weeks. Results The analysis included 3177 patients. In patients with less dyspnoea: indacaterol (both doses) improved 24-h post-dose (‘trough’) forced exp…
What drives inhaler prescription for asthma patients? Results from a real-life retrospective analysis
2020
Abstract Background The choice of inhaler device for asthma patients depends upon multiple attributes. We investigated factors that may drive general practitioners (GPs) and respiratory specialists in the prescription of inhaler devices for asthma patients who initiated inhalation therapy. Methods We retrospectively analysed prescriptions by GPs and respiratory specialists to asthma patients commencing inhaled corticosteroid/long-acting β2-agonist combination therapy available as both pressurised metered-dose inhalers (pMDIs) and dry powder inhalers (DPIs). Patient characteristics were compared by device and multivariate analysis was used to model the likelihood of receiving a pMDI as oppos…
Load match and grid interaction optimization of a net zero energy building through electricity storage: An Italian case-study
2016
The study aims at applying of Load Match and Grid Interaction indexes to a Net Zero Energy Building in order to optimize the performances of its energy systems. The case study is a modular prefabricated house that uses solar energy (photovoltaic) and natural gas (Fuel Cell) as energy sources and equipped with an Energy Management System addressing the optimal energy use.
Techno-economic analysis of off-grid hybrid renewable energy system for Sri Lanka
2014
Off grid hybrid renewable energy based power systems for rural electrification has become an attractive solution for areas where grid electricity is not feasible. Hybrid systems use several generation technologies, therefore the selection of proper technologies and optimum sizing of the components has become of great importance in reducing the overall cost and increasing the reliability of the service. The focus of this study has been to investigate the optimum configuration of a hybrid system which can supply electricity to a rural community in Sri Lanka. A rural village from the Siyambalanduwa region in Sri Lanka inhabiting approximately 150 households resulting approximate daily electric…
Method for size optimisation of large wind–hydrogen systems with high penetration on power grids
2013
Wind power generation is growing rapidly in many locations around the world. Power systems are able to absorb large amounts of wind capacity, but operational problems arise when the wind power penetration becomes high. Such factors as voltage dips, frequency variations, low power system stability, low reactive power and power flow imbalances reduce the economic value and represent a barrier to the unlimited development of wind energy. Hydrogen production from wind power that is not matched with hourly electricity demand appears to be an attractive storage option capable of providing a balancing service to the electricity generators and suppliers for mitigation of the negative impacts due to…
An optimal operating strategy for combined RES–based Generators and Electric Storage Systems for load shifting applications
2013
This paper focuses on an optimal operating strategy of combined RES-based generators and electric storage systems for small/medium-scale public facilities. The operating strategy can be used in load shifting applications in response to a time-of-use (TOU) rate design with differential pricing for on- and off-peak usage. Load shifting applications can be exploited by customers using battery energy storage systems (BESS) in order to reduce their electricity bill, charging the storage when off-peak time periods are applied and discharging it during on-peak periods, when electricity energy prices are high. The operating strategy is implemented within a bidirectional converter that provides an i…
Weighted estimates for diffeomorphic extensions of homeomorphisms
2019
Let $\Omega \subset \mbr^2$ be an internal chord-arc domain and $\varphi : \mbs^1 \rightarrow \partial \Omega$ be a homeomorphism. Then there is a diffeomorphic extension $h : \mbd \rightarrow \Omega$ of $\varphi .$ We study the relationship between weighted integrability of the derivatives of $h$ and double integrals of $\varphi$ and of $\varphi^{-1} .$
Amyloid Beta-Mediated Changes in Synaptic Function and Spine Number of Neocortical Neurons Depend on NMDA Receptors
2021
Onset and progression of Alzheimer’s disease (AD) pathophysiology differs between brain regions. The neocortex, for example, is a brain region that is affected very early during AD. NMDA receptors (NMDARs) are involved in mediating amyloid beta (Aβ) toxicity. NMDAR expression, on the other hand, can be affected by Aβ. We tested whether the high vulnerability of neocortical neurons for Aβ-toxicity may result from specific NMDAR expression profiles or from a particular regulation of NMDAR expression by Aβ. Electrophysiological analyses suggested that pyramidal cells of 6-months-old wildtype mice express mostly GluN1/GluN2A NMDARs. While synaptic NMDAR-mediated currents are unaltered in 5xFAD …
A Novel Operating Strategy for Customer-Side Energy Storages in Presence of Dynamic Electricity Prices
2015
In the wholesale energy market, electricity prices are determined by the balance between supply and demand. Normally, customers are not exposed to these variations but pay a constant electricity price. In an attempt to reduce demand peaks, several utilities are moving from a conventional fixed-rate pricing scheme to a new market-based model, based on time-of-use or real-time pricing, able to closely reflect the wholesale energy price. Electricity customers can thus take profit from the installation of storage systems, shifting their energy consumption from on-peak to off-peak periods. This paper presents a novel charging strategy to manage customer storage systems in presence of hourly elec…
Contribución de la Educación Científica a la apropiación de los Objetivos de Desarrollo Sostenible
2013
Durante la Cumbre de la Tierra Rio+20, celebrada en junio de 2012, se puso en marcha un ambicioso proceso para definir unos Objetivos del Desarrollo Sostenible (ODS) capaces de orientar la necesaria y urgente transición a la sostenibilidad de nuestras sociedades. Para contribuir a dicho esfuerzo colectivo de definición de los ODS y mostrar cómo la comunidad educativa puede favorecer su apropiación por la ciudadanía, hemos utilizado una estrategia, inspirada en el método Delphi, consistente en un proceso iterativo en el que se han puesto en común y valorado las aportaciones de 60 investigadores e investigadoras en el campo de la didáctica de las ciencias. Los más de un centenar de objetivos …