Search results for "d-a"

Absorption of oxybutynin from vaginal inserts: drug blood levels and the response of the rabbit bladder.

2000

Abstract Objectives. Oxybutynin has been used for treatment of urge urinary incontinence for more than 20 years. However, one of the major problems with its use is uncomfortable anticholinergic side effects that can lead to discontinuation of treatment. Alternative forms of drug administration may reduce side effects and thus improve patient compliance. Methods. A cylinder-shaped, curved silicone elastomer insert containing oxybutynin was anchored in the vagina of female rabbits. The inserts were designed to release oxybutynin at rates of 0.5, 1.0, and 5.0 mg/day, respectively. Blood drug and metabolite levels were monitored for 1 to 7 days and cystometry was carried out after 7 days of tre…

Co-activation of VEGF and NMDA receptors promotes synaptic targeting of AMPA receptors

2016

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior

2016

Vascular endothelial growth factor (VEGF) is known to be required for the action of antidepressant therapies but its impact on brain synaptic function is poorly characterized. Using a combination of electrophysiological, single-molecule imaging and conditional transgenic approaches, we identified the molecular basis of the VEGF effect on synaptic transmission and plasticity. VEGF increases the postsynaptic responses mediated by the N-methyl-D-aspartate type of glutamate receptors (GluNRs) in hippocampal neurons. This is concurrent with the formation of new synapses and with the synaptic recruitment of GluNR expressing the GluN2B subunit (GluNR-2B). VEGF induces a rapid redistribution of Glu…

Meeting Apart: Woody Allen's Characters, Films and Spectators

2007

An analysis of the relationships between Woody Allen's films (from "Take the Money and Run", 1969, to "Anything Else", 2003) and their spectators, starting frim a definition of the public image of the filmmaker then focusing on the film persona and the way the films represent authorial figures and the paradoxical meeting between film and spectator(s).

Electrophysiological and morphological properties of Cajal–Retzius cells with different ontogenetic origins

2010

International audience; The different origins of Cajal-Retzius cells (CRc) as well as their diverse molecular profile suggest that this cell type may represent different neuronal subpopulations. In order to investigate whether CRc from different origins show distinct functional or morphological characteristics we used transgenic Dbx1(cre);ROSA26(YFP) mice in which two subpopulations of CRc, originating from the septum and ventral pallium (VP) at the pallial-subpallial border (PSB), were permanently labeled by yellow fluorescent protein (YFP) expression. Electrophysiological properties of YFP(+) and YFP(-) CRc were investigated by whole-cell patch-clamp recordings, while a thorough somatoden…

Comment les séries font une fin : Urgences et Les Soprano. . Rouen. 12-14 septembre 2012

2012

International audience

Extraction of essential oil from Aloysia citriodora Palau leaves using continuous and pulsed ultrasound: Kinetics, antioxidant activity and antimicro…

2018

International audience; The impact of continuous and pulsed ultrasound pre-treatments (15, 30 and 45 min) followed by conventional hydrodistillation on the characteristics of extracted essential oils (EOs) from dried leaves of Aloysia citriodora Palau was evaluated for the first time. Chemical composition of EOs, antibacterial and antioxidant activities, as well as the contents in heavy metals (iron, copper, lead, arsenic, and cadmium) were determined. Pretreating the leaves with ultrasound (continuous and pulsed), before hydrodistillation, resulted in shorter extraction time (93.81–121.16 min) and higher extraction yields (2.8 (v/w) %) (p < 0.05), compared to the non-sonicated leaves (extr…

André Brink and the Afrikaner Heritage

2004

This paper shows how André Brink, dissident Afrikaans writer, tried to write against his heritage. The most visible strategy consisted in redefining Afrikanerdom as dissidence and as africanity. The notion of betrayal was systematically reversed so that the Afrikaners who supported the Afrikaner regime were presented as the real traitors. Yet dissidence was not an easy position for Brink and both he and his heroes had ambivalent positions.

Un post-humain post-apartheid ? Moxyland et Zoo Fiction de Lauren Beukes

2014

International audience

Le "changement de langue" d’Antjie Krog : "Babel heureuse"?

2010

This article examines the relationship between Afrikaans and English in post-apartheid South Africa though the prism of a specific example, Antjie Krog's Change of Tongue, whose generic and linguistic statuses plays on ambiguity and bilingualism.